| Full name: deoxyribonuclease 2 beta | Alias Symbol: DLAD | ||
| Type: protein-coding gene | Cytoband: 1p31.1-p22.3 | ||
| Entrez ID: 58511 | HGNC ID: HGNC:28875 | Ensembl Gene: ENSG00000137976 | OMIM ID: 608057 |
| Drug and gene relationship at DGIdb | |||
Expression of DNASE2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNASE2B | 58511 | 220380_at | 0.0300 | 0.9062 | |
| GSE20347 | DNASE2B | 58511 | 220380_at | 0.0787 | 0.2488 | |
| GSE23400 | DNASE2B | 58511 | 220380_at | -0.0619 | 0.0093 | |
| GSE26886 | DNASE2B | 58511 | 220380_at | 0.0266 | 0.8127 | |
| GSE29001 | DNASE2B | 58511 | 220380_at | -0.0401 | 0.7609 | |
| GSE38129 | DNASE2B | 58511 | 220380_at | 0.0376 | 0.5616 | |
| GSE45670 | DNASE2B | 58511 | 220380_at | 0.0928 | 0.2827 | |
| GSE53622 | DNASE2B | 58511 | 472 | 0.0281 | 0.8953 | |
| GSE53624 | DNASE2B | 58511 | 472 | 0.5422 | 0.0028 | |
| GSE63941 | DNASE2B | 58511 | 220380_at | 0.1348 | 0.3244 | |
| GSE77861 | DNASE2B | 58511 | 220380_at | -0.0758 | 0.3083 | |
| TCGA | DNASE2B | 58511 | RNAseq | -2.1310 | 0.0262 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DNASE2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNASE2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNASE2B | 58511 | 0 | 8 | 22 | |
| GSE20123 | DNASE2B | 58511 | 0 | 8 | 22 | |
| GSE43470 | DNASE2B | 58511 | 2 | 2 | 39 | |
| GSE46452 | DNASE2B | 58511 | 0 | 1 | 58 | |
| GSE47630 | DNASE2B | 58511 | 8 | 5 | 27 | |
| GSE54993 | DNASE2B | 58511 | 0 | 0 | 70 | |
| GSE54994 | DNASE2B | 58511 | 6 | 3 | 44 | |
| GSE60625 | DNASE2B | 58511 | 0 | 0 | 11 | |
| GSE74703 | DNASE2B | 58511 | 1 | 2 | 33 | |
| GSE74704 | DNASE2B | 58511 | 0 | 5 | 15 | |
| TCGA | DNASE2B | 58511 | 7 | 23 | 66 |
Total number of gains: 24; Total number of losses: 57; Total Number of normals: 407.
Somatic mutations of DNASE2B:
Generating mutation plots.
Highly correlated genes for DNASE2B:
Showing top 20/314 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNASE2B | HTN1 | 0.7362 | 3 | 0 | 3 |
| DNASE2B | DENND6B | 0.721552 | 3 | 0 | 3 |
| DNASE2B | PEX5L | 0.710879 | 3 | 0 | 3 |
| DNASE2B | GNG3 | 0.68869 | 3 | 0 | 3 |
| DNASE2B | ZMAT4 | 0.681966 | 3 | 0 | 3 |
| DNASE2B | SCGN | 0.676352 | 3 | 0 | 3 |
| DNASE2B | HRC | 0.67138 | 3 | 0 | 3 |
| DNASE2B | SLC5A7 | 0.669841 | 4 | 0 | 3 |
| DNASE2B | CYP2A7 | 0.66401 | 4 | 0 | 4 |
| DNASE2B | GAD2 | 0.65784 | 4 | 0 | 3 |
| DNASE2B | PSG7 | 0.653849 | 3 | 0 | 3 |
| DNASE2B | NTNG1 | 0.644389 | 4 | 0 | 4 |
| DNASE2B | PPP1R3A | 0.642212 | 4 | 0 | 4 |
| DNASE2B | CER1 | 0.640873 | 4 | 0 | 4 |
| DNASE2B | CCZ1 | 0.640054 | 4 | 0 | 3 |
| DNASE2B | RALYL | 0.638829 | 3 | 0 | 3 |
| DNASE2B | HECW1 | 0.63816 | 5 | 0 | 4 |
| DNASE2B | SLC22A2 | 0.637602 | 3 | 0 | 3 |
| DNASE2B | MYT1L | 0.63691 | 3 | 0 | 3 |
| DNASE2B | CRP | 0.635547 | 4 | 0 | 3 |
For details and further investigation, click here
