| Full name: pappalysin 2 | Alias Symbol: PAPPE|PAPP-A2 | ||
| Type: protein-coding gene | Cytoband: 1q25.2 | ||
| Entrez ID: 60676 | HGNC ID: HGNC:14615 | Ensembl Gene: ENSG00000116183 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PAPPA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAPPA2 | 60676 | 211918_x_at | -0.0221 | 0.9448 | |
| GSE20347 | PAPPA2 | 60676 | 211918_x_at | 0.1384 | 0.2736 | |
| GSE23400 | PAPPA2 | 60676 | 211918_x_at | -0.1373 | 0.0009 | |
| GSE26886 | PAPPA2 | 60676 | 211918_x_at | -0.2545 | 0.0310 | |
| GSE29001 | PAPPA2 | 60676 | 211918_x_at | -0.3208 | 0.1125 | |
| GSE38129 | PAPPA2 | 60676 | 211918_x_at | -0.0128 | 0.9274 | |
| GSE45670 | PAPPA2 | 60676 | 211918_x_at | 0.0893 | 0.3642 | |
| GSE53622 | PAPPA2 | 60676 | 7695 | 0.2497 | 0.0911 | |
| GSE53624 | PAPPA2 | 60676 | 7695 | 0.1113 | 0.5285 | |
| GSE63941 | PAPPA2 | 60676 | 211918_x_at | 0.2230 | 0.1615 | |
| GSE77861 | PAPPA2 | 60676 | 211918_x_at | -0.0466 | 0.6520 | |
| SRP159526 | PAPPA2 | 60676 | RNAseq | 4.6509 | 0.0000 | |
| TCGA | PAPPA2 | 60676 | RNAseq | -0.6362 | 0.2918 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PAPPA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAPPA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAPPA2 | 60676 | 11 | 0 | 19 | |
| GSE20123 | PAPPA2 | 60676 | 11 | 0 | 19 | |
| GSE43470 | PAPPA2 | 60676 | 7 | 2 | 34 | |
| GSE46452 | PAPPA2 | 60676 | 3 | 1 | 55 | |
| GSE47630 | PAPPA2 | 60676 | 14 | 0 | 26 | |
| GSE54993 | PAPPA2 | 60676 | 0 | 6 | 64 | |
| GSE54994 | PAPPA2 | 60676 | 15 | 0 | 38 | |
| GSE60625 | PAPPA2 | 60676 | 0 | 0 | 11 | |
| GSE74703 | PAPPA2 | 60676 | 7 | 2 | 27 | |
| GSE74704 | PAPPA2 | 60676 | 5 | 0 | 15 | |
| TCGA | PAPPA2 | 60676 | 40 | 3 | 53 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of PAPPA2:
Generating mutation plots.
Highly correlated genes for PAPPA2:
Showing top 20/1128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAPPA2 | NEUROD2 | 0.736879 | 4 | 0 | 4 |
| PAPPA2 | MUC13 | 0.729616 | 4 | 0 | 4 |
| PAPPA2 | GABRR2 | 0.727289 | 5 | 0 | 5 |
| PAPPA2 | GSX1 | 0.724714 | 3 | 0 | 3 |
| PAPPA2 | KIR3DL3 | 0.724614 | 5 | 0 | 5 |
| PAPPA2 | FCGR2C | 0.716794 | 4 | 0 | 4 |
| PAPPA2 | MAP3K19 | 0.715808 | 6 | 0 | 5 |
| PAPPA2 | ATF7 | 0.711147 | 3 | 0 | 3 |
| PAPPA2 | CER1 | 0.710391 | 5 | 0 | 4 |
| PAPPA2 | LUZP4 | 0.709763 | 6 | 0 | 6 |
| PAPPA2 | LINC00563 | 0.709241 | 5 | 0 | 5 |
| PAPPA2 | CDH15 | 0.707171 | 5 | 0 | 5 |
| PAPPA2 | KIR2DS3 | 0.70513 | 6 | 0 | 5 |
| PAPPA2 | EFR3B | 0.703479 | 4 | 0 | 4 |
| PAPPA2 | NHLH1 | 0.700128 | 4 | 0 | 3 |
| PAPPA2 | IHH | 0.699461 | 5 | 0 | 5 |
| PAPPA2 | FSCN3 | 0.699284 | 6 | 0 | 6 |
| PAPPA2 | PCBP3 | 0.69887 | 3 | 0 | 3 |
| PAPPA2 | NTNG1 | 0.697945 | 4 | 0 | 4 |
| PAPPA2 | SCNN1G | 0.695822 | 5 | 0 | 5 |
For details and further investigation, click here
