| Full name: solute carrier family 10 member 1 | Alias Symbol: NTCP | ||
| Type: protein-coding gene | Cytoband: 14q24.1 | ||
| Entrez ID: 6554 | HGNC ID: HGNC:10905 | Ensembl Gene: ENSG00000100652 | OMIM ID: 182396 |
| Drug and gene relationship at DGIdb | |||
SLC10A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04976 | Bile secretion |
Expression of SLC10A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC10A1 | 6554 | 207185_at | -0.0738 | 0.6964 | |
| GSE20347 | SLC10A1 | 6554 | 207185_at | 0.0706 | 0.5284 | |
| GSE23400 | SLC10A1 | 6554 | 207185_at | -0.1378 | 0.0066 | |
| GSE26886 | SLC10A1 | 6554 | 207185_at | -0.0324 | 0.8198 | |
| GSE29001 | SLC10A1 | 6554 | 207185_at | -0.2124 | 0.2246 | |
| GSE38129 | SLC10A1 | 6554 | 207185_at | -0.1323 | 0.2369 | |
| GSE45670 | SLC10A1 | 6554 | 207185_at | 0.0261 | 0.7979 | |
| GSE53622 | SLC10A1 | 6554 | 93425 | -0.2579 | 0.0064 | |
| GSE53624 | SLC10A1 | 6554 | 93425 | -0.0561 | 0.5304 | |
| GSE63941 | SLC10A1 | 6554 | 207185_at | 0.1142 | 0.4249 | |
| GSE77861 | SLC10A1 | 6554 | 207185_at | -0.0579 | 0.6708 | |
| GSE97050 | SLC10A1 | 6554 | A_23_P25698 | -0.2707 | 0.4288 | |
| SRP133303 | SLC10A1 | 6554 | RNAseq | -1.4395 | 0.0000 | |
| SRP193095 | SLC10A1 | 6554 | RNAseq | -1.1144 | 0.0000 | |
| TCGA | SLC10A1 | 6554 | RNAseq | -1.0735 | 0.1447 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SLC10A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC10A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC10A1 | 6554 | 8 | 3 | 19 | |
| GSE20123 | SLC10A1 | 6554 | 8 | 3 | 19 | |
| GSE43470 | SLC10A1 | 6554 | 8 | 3 | 32 | |
| GSE46452 | SLC10A1 | 6554 | 16 | 3 | 40 | |
| GSE47630 | SLC10A1 | 6554 | 11 | 9 | 20 | |
| GSE54993 | SLC10A1 | 6554 | 3 | 9 | 58 | |
| GSE54994 | SLC10A1 | 6554 | 18 | 5 | 30 | |
| GSE60625 | SLC10A1 | 6554 | 0 | 2 | 9 | |
| GSE74703 | SLC10A1 | 6554 | 7 | 3 | 26 | |
| GSE74704 | SLC10A1 | 6554 | 3 | 3 | 14 | |
| TCGA | SLC10A1 | 6554 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of SLC10A1:
Generating mutation plots.
Highly correlated genes for SLC10A1:
Showing top 20/1037 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC10A1 | SIGLEC7 | 0.776661 | 5 | 0 | 5 |
| SLC10A1 | XRCC2 | 0.775584 | 3 | 0 | 3 |
| SLC10A1 | KHDRBS2 | 0.766909 | 5 | 0 | 5 |
| SLC10A1 | ART1 | 0.76413 | 5 | 0 | 5 |
| SLC10A1 | PDCD1 | 0.757588 | 3 | 0 | 3 |
| SLC10A1 | KLK2 | 0.753665 | 5 | 0 | 4 |
| SLC10A1 | PPIL2 | 0.747941 | 3 | 0 | 3 |
| SLC10A1 | SHC2 | 0.741232 | 3 | 0 | 3 |
| SLC10A1 | TCTE3 | 0.733109 | 3 | 0 | 3 |
| SLC10A1 | OR10C1 | 0.732107 | 5 | 0 | 5 |
| SLC10A1 | C16orf71 | 0.727738 | 4 | 0 | 4 |
| SLC10A1 | CETN1 | 0.723289 | 4 | 0 | 3 |
| SLC10A1 | IFNA4 | 0.722621 | 6 | 0 | 6 |
| SLC10A1 | FAM153A | 0.72209 | 4 | 0 | 3 |
| SLC10A1 | CALCR | 0.721171 | 6 | 0 | 5 |
| SLC10A1 | C21orf62 | 0.720238 | 6 | 0 | 6 |
| SLC10A1 | IL25 | 0.716704 | 5 | 0 | 5 |
| SLC10A1 | MYO15B | 0.715584 | 3 | 0 | 3 |
| SLC10A1 | FOLH1 | 0.713479 | 7 | 0 | 6 |
| SLC10A1 | AMACR | 0.711244 | 5 | 0 | 5 |
For details and further investigation, click here
