| Full name: diacylglycerol kinase epsilon | Alias Symbol: DAGK6|DGK | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 8526 | HGNC ID: HGNC:2852 | Ensembl Gene: ENSG00000153933 | OMIM ID: 601440 |
| Drug and gene relationship at DGIdb | |||
Expression of DGKE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DGKE | 8526 | 238694_at | -0.0306 | 0.9600 | |
| GSE20347 | DGKE | 8526 | 207518_at | -0.0440 | 0.4293 | |
| GSE23400 | DGKE | 8526 | 207518_at | -0.0182 | 0.3414 | |
| GSE26886 | DGKE | 8526 | 238694_at | 1.2422 | 0.0000 | |
| GSE29001 | DGKE | 8526 | 207518_at | -0.0523 | 0.6571 | |
| GSE38129 | DGKE | 8526 | 207518_at | 0.0605 | 0.2099 | |
| GSE45670 | DGKE | 8526 | 238694_at | -0.4886 | 0.0627 | |
| GSE53622 | DGKE | 8526 | 20279 | -0.1383 | 0.2880 | |
| GSE53624 | DGKE | 8526 | 20279 | -0.0546 | 0.5690 | |
| GSE63941 | DGKE | 8526 | 238694_at | -0.2798 | 0.5867 | |
| GSE77861 | DGKE | 8526 | 1554621_at | -0.0713 | 0.5277 | |
| GSE97050 | DGKE | 8526 | A_33_P3411291 | -0.0785 | 0.7698 | |
| SRP007169 | DGKE | 8526 | RNAseq | 1.0000 | 0.0616 | |
| SRP008496 | DGKE | 8526 | RNAseq | 1.1557 | 0.0007 | |
| SRP064894 | DGKE | 8526 | RNAseq | -0.1444 | 0.4370 | |
| SRP133303 | DGKE | 8526 | RNAseq | 0.3427 | 0.2992 | |
| SRP159526 | DGKE | 8526 | RNAseq | 0.2229 | 0.3545 | |
| SRP193095 | DGKE | 8526 | RNAseq | -0.0310 | 0.7688 | |
| SRP219564 | DGKE | 8526 | RNAseq | -0.0507 | 0.8861 | |
| TCGA | DGKE | 8526 | RNAseq | -0.1249 | 0.1585 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DGKE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DGKE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DGKE | 8526 | 5 | 1 | 24 | |
| GSE20123 | DGKE | 8526 | 5 | 1 | 24 | |
| GSE43470 | DGKE | 8526 | 3 | 1 | 39 | |
| GSE46452 | DGKE | 8526 | 32 | 0 | 27 | |
| GSE47630 | DGKE | 8526 | 7 | 1 | 32 | |
| GSE54993 | DGKE | 8526 | 2 | 4 | 64 | |
| GSE54994 | DGKE | 8526 | 9 | 5 | 39 | |
| GSE60625 | DGKE | 8526 | 4 | 0 | 7 | |
| GSE74703 | DGKE | 8526 | 3 | 1 | 32 | |
| GSE74704 | DGKE | 8526 | 4 | 1 | 15 | |
| TCGA | DGKE | 8526 | 27 | 6 | 63 |
Total number of gains: 101; Total number of losses: 21; Total Number of normals: 366.
Somatic mutations of DGKE:
Generating mutation plots.
Highly correlated genes for DGKE:
Showing top 20/39 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DGKE | AKAP1 | 0.712208 | 3 | 0 | 3 |
| DGKE | SYP | 0.691012 | 3 | 0 | 3 |
| DGKE | ZNF358 | 0.649738 | 4 | 0 | 3 |
| DGKE | NAP1L5 | 0.643554 | 3 | 0 | 3 |
| DGKE | SMIM8 | 0.631197 | 4 | 0 | 3 |
| DGKE | PDZD4 | 0.625742 | 3 | 0 | 3 |
| DGKE | TOB1-AS1 | 0.613144 | 3 | 0 | 3 |
| DGKE | SMIM1 | 0.610189 | 3 | 0 | 3 |
| DGKE | ASMTL | 0.605212 | 4 | 0 | 3 |
| DGKE | CRTC1 | 0.599812 | 3 | 0 | 3 |
| DGKE | TCEA2 | 0.589814 | 5 | 0 | 4 |
| DGKE | DICER1-AS1 | 0.587848 | 3 | 0 | 3 |
| DGKE | NTNG2 | 0.579578 | 4 | 0 | 3 |
| DGKE | RSBN1L | 0.576976 | 4 | 0 | 3 |
| DGKE | AXIN2 | 0.575829 | 4 | 0 | 3 |
| DGKE | TRAF3IP2-AS1 | 0.570626 | 4 | 0 | 3 |
| DGKE | HECTD2 | 0.562192 | 4 | 0 | 3 |
| DGKE | FOXD3-AS1 | 0.561383 | 3 | 0 | 3 |
| DGKE | DTX3 | 0.557009 | 5 | 0 | 3 |
| DGKE | NCAM1 | 0.553547 | 4 | 0 | 3 |
For details and further investigation, click here
