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File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Function: require_once

Multi-Omics Database of ESCC

 

TOB1-AS1

 

Full name: TOB1 antisense RNA 1 Alias Symbol: 
Type: non-coding RNA Cytoband: 17q21.33
Entrez ID: 400604 HGNC ID: HGNC:44340 Ensembl Gene: ENSG00000229980 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of TOB1-AS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TOB1-AS1 400604 241405_at 0.0098 0.9730
GSE26886 TOB1-AS1 400604 241405_at -0.0252 0.8774
GSE45670 TOB1-AS1 400604 241405_at -0.0299 0.8230
GSE53622 TOB1-AS1 400604 56577 -0.6169 0.0000
GSE53624 TOB1-AS1 400604 56577 -0.3659 0.0000
GSE63941 TOB1-AS1 400604 241405_at 0.4329 0.0617
GSE77861 TOB1-AS1 400604 241405_at -0.1306 0.1842
SRP133303 TOB1-AS1 400604 RNAseq -0.1143 0.7795
SRP159526 TOB1-AS1 400604 RNAseq -0.6871 0.1266
SRP219564 TOB1-AS1 400604 RNAseq -0.7689 0.1932

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TOB1-AS1 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of TOB1-AS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TOB1-AS1 400604 5 2 23
GSE20123 TOB1-AS1 400604 5 2 23
GSE43470 TOB1-AS1 400604 3 2 38
GSE46452 TOB1-AS1 400604 32 0 27
GSE47630 TOB1-AS1 400604 9 0 31
GSE54993 TOB1-AS1 400604 2 4 64
GSE54994 TOB1-AS1 400604 8 6 39
GSE60625 TOB1-AS1 400604 4 0 7
GSE74703 TOB1-AS1 400604 3 2 31
GSE74704 TOB1-AS1 400604 4 1 15

Total number of gains: 75; Total number of losses: 19; Total Number of normals: 298.  

 

Somatic mutations of TOB1-AS1:

 

Generating mutation plots.

 

Highly correlated genes for TOB1-AS1:

 

Showing top 20/77 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TOB1-AS1SMPX0.674299303
TOB1-AS1CADM20.662613303
TOB1-AS1PLEKHB10.658273505
TOB1-AS1GALR10.652722303
TOB1-AS1TNRC6C0.645025303
TOB1-AS1COQ70.635186404
TOB1-AS1ZG160.631234403
TOB1-AS1SV2C0.626507303
TOB1-AS1PBLD0.626229303
TOB1-AS1REPS20.621299404
TOB1-AS1HIGD2A0.620853503
TOB1-AS1PCBD10.617481605
TOB1-AS1INPP5A0.616427303
TOB1-AS1ZNF1740.614389303
TOB1-AS1DGKE0.613144303
TOB1-AS1FAM149B10.612065303
TOB1-AS1ANGPTL70.608139403
TOB1-AS1HID10.605515404
TOB1-AS1CA10.605244303
TOB1-AS1TMEM8B0.603899403

For details and further investigation, click here