| Full name: CREB regulated transcription coactivator 1 | Alias Symbol: KIAA0616|FLJ14027|TORC1 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 23373 | HGNC ID: HGNC:16062 | Ensembl Gene: ENSG00000105662 | OMIM ID: 607536 |
| Drug and gene relationship at DGIdb | |||
CRTC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05166 | HTLV-I infection |
Expression of CRTC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRTC1 | 23373 | 213091_at | -0.1504 | 0.5212 | |
| GSE20347 | CRTC1 | 23373 | 213091_at | -0.0231 | 0.7942 | |
| GSE23400 | CRTC1 | 23373 | 207159_x_at | -0.1342 | 0.0009 | |
| GSE26886 | CRTC1 | 23373 | 207159_x_at | 0.1295 | 0.3933 | |
| GSE29001 | CRTC1 | 23373 | 213091_at | -0.1183 | 0.5573 | |
| GSE38129 | CRTC1 | 23373 | 213091_at | -0.2606 | 0.0044 | |
| GSE45670 | CRTC1 | 23373 | 213091_at | -0.0695 | 0.4528 | |
| GSE53622 | CRTC1 | 23373 | 91054 | -0.2518 | 0.0058 | |
| GSE53624 | CRTC1 | 23373 | 91054 | -0.1629 | 0.0459 | |
| GSE63941 | CRTC1 | 23373 | 213091_at | 0.4348 | 0.0141 | |
| GSE77861 | CRTC1 | 23373 | 207159_x_at | -0.0900 | 0.6382 | |
| GSE97050 | CRTC1 | 23373 | A_33_P3331882 | -0.4949 | 0.3142 | |
| SRP064894 | CRTC1 | 23373 | RNAseq | 0.5450 | 0.0166 | |
| SRP133303 | CRTC1 | 23373 | RNAseq | -0.1800 | 0.2892 | |
| SRP159526 | CRTC1 | 23373 | RNAseq | 0.3080 | 0.4344 | |
| SRP193095 | CRTC1 | 23373 | RNAseq | 0.3978 | 0.0336 | |
| SRP219564 | CRTC1 | 23373 | RNAseq | 0.9789 | 0.0719 | |
| TCGA | CRTC1 | 23373 | RNAseq | -0.3300 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRTC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRTC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRTC1 | 23373 | 4 | 5 | 21 | |
| GSE20123 | CRTC1 | 23373 | 3 | 3 | 24 | |
| GSE43470 | CRTC1 | 23373 | 2 | 5 | 36 | |
| GSE46452 | CRTC1 | 23373 | 47 | 1 | 11 | |
| GSE47630 | CRTC1 | 23373 | 5 | 8 | 27 | |
| GSE54993 | CRTC1 | 23373 | 16 | 4 | 50 | |
| GSE54994 | CRTC1 | 23373 | 6 | 13 | 34 | |
| GSE60625 | CRTC1 | 23373 | 9 | 0 | 2 | |
| GSE74703 | CRTC1 | 23373 | 2 | 3 | 31 | |
| GSE74704 | CRTC1 | 23373 | 0 | 3 | 17 | |
| TCGA | CRTC1 | 23373 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of CRTC1:
Generating mutation plots.
Highly correlated genes for CRTC1:
Showing top 20/912 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRTC1 | SRRM3 | 0.756367 | 3 | 0 | 3 |
| CRTC1 | TSKS | 0.71647 | 3 | 0 | 3 |
| CRTC1 | C7orf61 | 0.711323 | 3 | 0 | 3 |
| CRTC1 | TMEM255B | 0.700665 | 3 | 0 | 3 |
| CRTC1 | DPPA4 | 0.69829 | 3 | 0 | 3 |
| CRTC1 | UCK1 | 0.698286 | 3 | 0 | 3 |
| CRTC1 | DOK7 | 0.697092 | 4 | 0 | 4 |
| CRTC1 | KCNJ3 | 0.691594 | 3 | 0 | 3 |
| CRTC1 | ASTN1 | 0.690269 | 5 | 0 | 4 |
| CRTC1 | SCARA5 | 0.689709 | 4 | 0 | 4 |
| CRTC1 | STXBP6 | 0.684084 | 4 | 0 | 4 |
| CRTC1 | C22orf23 | 0.683149 | 3 | 0 | 3 |
| CRTC1 | KLHL41 | 0.677984 | 3 | 0 | 3 |
| CRTC1 | EPS8L3 | 0.676848 | 4 | 0 | 4 |
| CRTC1 | TFF1 | 0.676044 | 3 | 0 | 3 |
| CRTC1 | REM1 | 0.672556 | 6 | 0 | 6 |
| CRTC1 | KCNJ10 | 0.670219 | 4 | 0 | 4 |
| CRTC1 | TAAR2 | 0.670185 | 4 | 0 | 4 |
| CRTC1 | OR2H2 | 0.668864 | 7 | 0 | 7 |
| CRTC1 | TUBB4A | 0.658122 | 3 | 0 | 3 |
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