| Full name: A-kinase anchoring protein 1 | Alias Symbol: AKAP121|AKAP149|SAKAP84|S-AKAP84|AKAP84|D-AKAP1|PPP1R43|TDRD17 | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 8165 | HGNC ID: HGNC:367 | Ensembl Gene: ENSG00000121057 | OMIM ID: 602449 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AKAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP1 | 8165 | 201675_at | -0.1338 | 0.8628 | |
| GSE20347 | AKAP1 | 8165 | 201675_at | 0.2846 | 0.0553 | |
| GSE23400 | AKAP1 | 8165 | 201674_s_at | -0.0635 | 0.5482 | |
| GSE26886 | AKAP1 | 8165 | 201674_s_at | 0.0862 | 0.7759 | |
| GSE29001 | AKAP1 | 8165 | 201674_s_at | -0.0646 | 0.8525 | |
| GSE38129 | AKAP1 | 8165 | 201675_at | 0.0604 | 0.7077 | |
| GSE45670 | AKAP1 | 8165 | 201675_at | -0.2872 | 0.1897 | |
| GSE53622 | AKAP1 | 8165 | 45778 | -0.2439 | 0.0039 | |
| GSE53624 | AKAP1 | 8165 | 120052 | -0.0392 | 0.6154 | |
| GSE63941 | AKAP1 | 8165 | 201675_at | 1.0715 | 0.0098 | |
| GSE77861 | AKAP1 | 8165 | 201675_at | 0.3108 | 0.1094 | |
| GSE97050 | AKAP1 | 8165 | A_33_P3324428 | -0.4620 | 0.2852 | |
| SRP007169 | AKAP1 | 8165 | RNAseq | 1.3211 | 0.0077 | |
| SRP008496 | AKAP1 | 8165 | RNAseq | 1.3588 | 0.0007 | |
| SRP064894 | AKAP1 | 8165 | RNAseq | -0.1013 | 0.4153 | |
| SRP133303 | AKAP1 | 8165 | RNAseq | 0.1414 | 0.5960 | |
| SRP159526 | AKAP1 | 8165 | RNAseq | -0.1127 | 0.5875 | |
| SRP193095 | AKAP1 | 8165 | RNAseq | -0.3194 | 0.0648 | |
| SRP219564 | AKAP1 | 8165 | RNAseq | -0.0001 | 0.9998 | |
| TCGA | AKAP1 | 8165 | RNAseq | -0.2958 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by AKAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP1 | 8165 | 5 | 1 | 24 | |
| GSE20123 | AKAP1 | 8165 | 5 | 1 | 24 | |
| GSE43470 | AKAP1 | 8165 | 3 | 1 | 39 | |
| GSE46452 | AKAP1 | 8165 | 32 | 0 | 27 | |
| GSE47630 | AKAP1 | 8165 | 7 | 1 | 32 | |
| GSE54993 | AKAP1 | 8165 | 2 | 4 | 64 | |
| GSE54994 | AKAP1 | 8165 | 8 | 6 | 39 | |
| GSE60625 | AKAP1 | 8165 | 4 | 0 | 7 | |
| GSE74703 | AKAP1 | 8165 | 3 | 1 | 32 | |
| GSE74704 | AKAP1 | 8165 | 4 | 1 | 15 | |
| TCGA | AKAP1 | 8165 | 28 | 6 | 62 |
Total number of gains: 101; Total number of losses: 22; Total Number of normals: 365.
Somatic mutations of AKAP1:
Generating mutation plots.
Highly correlated genes for AKAP1:
Showing top 20/123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP1 | DGKE | 0.712208 | 3 | 0 | 3 |
| AKAP1 | GKAP1 | 0.679054 | 4 | 0 | 3 |
| AKAP1 | PDZD4 | 0.662565 | 3 | 0 | 3 |
| AKAP1 | SLC25A4 | 0.662072 | 9 | 0 | 8 |
| AKAP1 | ARL6IP4 | 0.636754 | 4 | 0 | 4 |
| AKAP1 | RPL3 | 0.627646 | 4 | 0 | 4 |
| AKAP1 | ITGB1BP2 | 0.626518 | 4 | 0 | 3 |
| AKAP1 | ZBTB10 | 0.623839 | 4 | 0 | 3 |
| AKAP1 | AUTS2 | 0.619058 | 4 | 0 | 3 |
| AKAP1 | KBTBD12 | 0.61219 | 4 | 0 | 3 |
| AKAP1 | RNF115 | 0.611646 | 5 | 0 | 4 |
| AKAP1 | SCAI | 0.6109 | 4 | 0 | 4 |
| AKAP1 | NFYC | 0.603302 | 3 | 0 | 3 |
| AKAP1 | KLHL23 | 0.598863 | 5 | 0 | 4 |
| AKAP1 | MLLT6 | 0.597753 | 4 | 0 | 3 |
| AKAP1 | PM20D2 | 0.594567 | 6 | 0 | 5 |
| AKAP1 | SRSF7 | 0.592219 | 6 | 0 | 5 |
| AKAP1 | PIH1D1 | 0.586488 | 3 | 0 | 3 |
| AKAP1 | RPL6 | 0.586311 | 4 | 0 | 3 |
| AKAP1 | MRPL34 | 0.585935 | 7 | 0 | 6 |
For details and further investigation, click here
