| Full name: HECT domain E3 ubiquitin protein ligase 2 | Alias Symbol: FLJ37306 | ||
| Type: protein-coding gene | Cytoband: 10q23.32 | ||
| Entrez ID: 143279 | HGNC ID: HGNC:26736 | Ensembl Gene: ENSG00000165338 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of HECTD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HECTD2 | 143279 | 227568_at | -0.4620 | 0.4642 | |
| GSE26886 | HECTD2 | 143279 | 227568_at | 0.6970 | 0.0156 | |
| GSE45670 | HECTD2 | 143279 | 227568_at | -0.5868 | 0.0027 | |
| GSE53622 | HECTD2 | 143279 | 109137 | -0.2930 | 0.0014 | |
| GSE53624 | HECTD2 | 143279 | 109137 | -0.3134 | 0.0000 | |
| GSE63941 | HECTD2 | 143279 | 227568_at | -2.5981 | 0.0002 | |
| GSE77861 | HECTD2 | 143279 | 227568_at | -0.1152 | 0.6125 | |
| GSE97050 | HECTD2 | 143279 | A_32_P201979 | -0.4254 | 0.3156 | |
| SRP007169 | HECTD2 | 143279 | RNAseq | 0.2101 | 0.6382 | |
| SRP008496 | HECTD2 | 143279 | RNAseq | 0.5648 | 0.0766 | |
| SRP064894 | HECTD2 | 143279 | RNAseq | -0.0229 | 0.9407 | |
| SRP133303 | HECTD2 | 143279 | RNAseq | 0.2687 | 0.1476 | |
| SRP159526 | HECTD2 | 143279 | RNAseq | -0.0375 | 0.9093 | |
| SRP193095 | HECTD2 | 143279 | RNAseq | -0.0237 | 0.7999 | |
| SRP219564 | HECTD2 | 143279 | RNAseq | 0.3406 | 0.3604 | |
| TCGA | HECTD2 | 143279 | RNAseq | -0.1858 | 0.0207 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HECTD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HECTD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HECTD2 | 143279 | 1 | 7 | 22 | |
| GSE20123 | HECTD2 | 143279 | 1 | 6 | 23 | |
| GSE43470 | HECTD2 | 143279 | 0 | 8 | 35 | |
| GSE46452 | HECTD2 | 143279 | 0 | 11 | 48 | |
| GSE47630 | HECTD2 | 143279 | 2 | 14 | 24 | |
| GSE54993 | HECTD2 | 143279 | 7 | 0 | 63 | |
| GSE54994 | HECTD2 | 143279 | 1 | 10 | 42 | |
| GSE60625 | HECTD2 | 143279 | 0 | 0 | 11 | |
| GSE74703 | HECTD2 | 143279 | 0 | 6 | 30 | |
| GSE74704 | HECTD2 | 143279 | 0 | 4 | 16 | |
| TCGA | HECTD2 | 143279 | 7 | 27 | 62 |
Total number of gains: 19; Total number of losses: 93; Total Number of normals: 376.
Somatic mutations of HECTD2:
Generating mutation plots.
Highly correlated genes for HECTD2:
Showing top 20/438 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HECTD2 | PPP1R12C | 0.774965 | 3 | 0 | 3 |
| HECTD2 | GADL1 | 0.742615 | 3 | 0 | 3 |
| HECTD2 | ADAMTSL3 | 0.731093 | 3 | 0 | 3 |
| HECTD2 | NPY | 0.727746 | 3 | 0 | 3 |
| HECTD2 | LINC00702 | 0.725607 | 3 | 0 | 3 |
| HECTD2 | SMIM10 | 0.722811 | 4 | 0 | 4 |
| HECTD2 | CACNA1C | 0.722796 | 4 | 0 | 4 |
| HECTD2 | ATPAF1 | 0.720383 | 4 | 0 | 4 |
| HECTD2 | BCL6 | 0.712533 | 3 | 0 | 3 |
| HECTD2 | FGF13 | 0.710128 | 3 | 0 | 3 |
| HECTD2 | LMO3 | 0.708138 | 3 | 0 | 3 |
| HECTD2 | RGMB | 0.705223 | 4 | 0 | 3 |
| HECTD2 | SGCD | 0.705207 | 4 | 0 | 4 |
| HECTD2 | ANKRD40 | 0.697134 | 3 | 0 | 3 |
| HECTD2 | PPP3CB | 0.695066 | 6 | 0 | 5 |
| HECTD2 | MRGPRF | 0.692854 | 4 | 0 | 3 |
| HECTD2 | FZD7 | 0.692205 | 3 | 0 | 3 |
| HECTD2 | ABCA9 | 0.688333 | 3 | 0 | 3 |
| HECTD2 | PDE4DIP | 0.68832 | 3 | 0 | 3 |
| HECTD2 | CLIP3 | 0.688035 | 4 | 0 | 3 |
For details and further investigation, click here
