| Full name: axin 2 | Alias Symbol: MGC126582|DKFZp781B0869 | ||
| Type: protein-coding gene | Cytoband: 17q24.1 | ||
| Entrez ID: 8313 | HGNC ID: HGNC:904 | Ensembl Gene: ENSG00000168646 | OMIM ID: 604025 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
AXIN2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway | |
| hsa04390 | Hippo signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | |
| hsa05213 | Endometrial cancer |
Expression of AXIN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AXIN2 | 8313 | 222696_at | -0.5843 | 0.3911 | |
| GSE26886 | AXIN2 | 8313 | 222696_at | 0.6160 | 0.0916 | |
| GSE45670 | AXIN2 | 8313 | 222696_at | -0.5618 | 0.0086 | |
| GSE53622 | AXIN2 | 8313 | 106547 | -0.3136 | 0.0275 | |
| GSE53624 | AXIN2 | 8313 | 106547 | -0.2173 | 0.0816 | |
| GSE63941 | AXIN2 | 8313 | 224176_s_at | 0.0612 | 0.7772 | |
| GSE77861 | AXIN2 | 8313 | 224176_s_at | 0.0622 | 0.6864 | |
| GSE97050 | AXIN2 | 8313 | A_23_P148015 | -0.4220 | 0.4240 | |
| SRP007169 | AXIN2 | 8313 | RNAseq | 1.9111 | 0.0178 | |
| SRP064894 | AXIN2 | 8313 | RNAseq | -0.0825 | 0.8061 | |
| SRP133303 | AXIN2 | 8313 | RNAseq | -0.3780 | 0.2530 | |
| SRP159526 | AXIN2 | 8313 | RNAseq | -0.2042 | 0.4981 | |
| SRP193095 | AXIN2 | 8313 | RNAseq | 0.1323 | 0.7017 | |
| SRP219564 | AXIN2 | 8313 | RNAseq | -0.1247 | 0.8574 | |
| TCGA | AXIN2 | 8313 | RNAseq | -0.5311 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AXIN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AXIN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AXIN2 | 8313 | 3 | 1 | 26 | |
| GSE20123 | AXIN2 | 8313 | 3 | 1 | 26 | |
| GSE43470 | AXIN2 | 8313 | 6 | 0 | 37 | |
| GSE46452 | AXIN2 | 8313 | 32 | 0 | 27 | |
| GSE47630 | AXIN2 | 8313 | 7 | 1 | 32 | |
| GSE54993 | AXIN2 | 8313 | 2 | 5 | 63 | |
| GSE54994 | AXIN2 | 8313 | 9 | 4 | 40 | |
| GSE60625 | AXIN2 | 8313 | 4 | 0 | 7 | |
| GSE74703 | AXIN2 | 8313 | 6 | 0 | 30 | |
| GSE74704 | AXIN2 | 8313 | 3 | 1 | 16 | |
| TCGA | AXIN2 | 8313 | 30 | 8 | 58 |
Total number of gains: 105; Total number of losses: 21; Total Number of normals: 362.
Somatic mutations of AXIN2:
Generating mutation plots.
Highly correlated genes for AXIN2:
Showing top 20/303 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AXIN2 | DNM3OS | 0.6994 | 3 | 0 | 3 |
| AXIN2 | LINC01279 | 0.697537 | 3 | 0 | 3 |
| AXIN2 | JAM3 | 0.694777 | 6 | 0 | 6 |
| AXIN2 | PRKG1 | 0.693489 | 4 | 0 | 4 |
| AXIN2 | GALNT15 | 0.690511 | 3 | 0 | 3 |
| AXIN2 | CYS1 | 0.674079 | 5 | 0 | 5 |
| AXIN2 | ZNF423 | 0.665971 | 4 | 0 | 3 |
| AXIN2 | STARD9 | 0.665518 | 3 | 0 | 3 |
| AXIN2 | PLN | 0.663927 | 5 | 0 | 5 |
| AXIN2 | NME5 | 0.663485 | 4 | 0 | 4 |
| AXIN2 | MYCT1 | 0.663208 | 3 | 0 | 3 |
| AXIN2 | CDS2 | 0.66301 | 3 | 0 | 3 |
| AXIN2 | RHOJ | 0.660423 | 3 | 0 | 3 |
| AXIN2 | RUNX1T1 | 0.660406 | 5 | 0 | 5 |
| AXIN2 | CACNB2 | 0.65769 | 3 | 0 | 3 |
| AXIN2 | HMCN1 | 0.657625 | 6 | 0 | 6 |
| AXIN2 | HSPB3 | 0.657398 | 3 | 0 | 3 |
| AXIN2 | SYT11 | 0.652975 | 5 | 0 | 4 |
| AXIN2 | PKIG | 0.652376 | 5 | 0 | 5 |
| AXIN2 | JAZF1 | 0.652239 | 5 | 0 | 4 |
For details and further investigation, click here
