| Full name: deltex E3 ubiquitin ligase 3 | Alias Symbol: FLJ34766|RNF154 | ||
| Type: protein-coding gene | Cytoband: 12q13.3 | ||
| Entrez ID: 196403 | HGNC ID: HGNC:24457 | Ensembl Gene: ENSG00000178498 | OMIM ID: 613142 |
| Drug and gene relationship at DGIdb | |||
DTX3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of DTX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DTX3 | 196403 | 235721_at | -0.1670 | 0.8383 | |
| GSE20347 | DTX3 | 196403 | 49049_at | -0.0207 | 0.8346 | |
| GSE23400 | DTX3 | 196403 | 221835_at | -0.1456 | 0.0001 | |
| GSE26886 | DTX3 | 196403 | 235721_at | 1.4417 | 0.0000 | |
| GSE29001 | DTX3 | 196403 | 222022_at | 0.1691 | 0.3186 | |
| GSE38129 | DTX3 | 196403 | 49049_at | -0.0770 | 0.4187 | |
| GSE45670 | DTX3 | 196403 | 235721_at | -0.3240 | 0.1449 | |
| GSE53622 | DTX3 | 196403 | 81658 | 0.1486 | 0.2567 | |
| GSE53624 | DTX3 | 196403 | 81658 | 0.1765 | 0.0179 | |
| GSE63941 | DTX3 | 196403 | 235721_at | -0.7164 | 0.3368 | |
| GSE77861 | DTX3 | 196403 | 235721_at | 0.3507 | 0.0891 | |
| GSE97050 | DTX3 | 196403 | A_24_P359405 | -0.2083 | 0.5316 | |
| SRP007169 | DTX3 | 196403 | RNAseq | 2.2472 | 0.0002 | |
| SRP008496 | DTX3 | 196403 | RNAseq | 1.9593 | 0.0000 | |
| SRP064894 | DTX3 | 196403 | RNAseq | 0.7303 | 0.0001 | |
| SRP133303 | DTX3 | 196403 | RNAseq | 0.3210 | 0.1718 | |
| SRP159526 | DTX3 | 196403 | RNAseq | 0.9360 | 0.0560 | |
| SRP193095 | DTX3 | 196403 | RNAseq | 1.3659 | 0.0000 | |
| SRP219564 | DTX3 | 196403 | RNAseq | 0.1211 | 0.8503 | |
| TCGA | DTX3 | 196403 | RNAseq | 0.0538 | 0.6491 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by DTX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DTX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DTX3 | 196403 | 7 | 1 | 22 | |
| GSE20123 | DTX3 | 196403 | 7 | 0 | 23 | |
| GSE43470 | DTX3 | 196403 | 2 | 0 | 41 | |
| GSE46452 | DTX3 | 196403 | 8 | 1 | 50 | |
| GSE47630 | DTX3 | 196403 | 10 | 2 | 28 | |
| GSE54993 | DTX3 | 196403 | 0 | 5 | 65 | |
| GSE54994 | DTX3 | 196403 | 4 | 1 | 48 | |
| GSE60625 | DTX3 | 196403 | 0 | 0 | 11 | |
| GSE74703 | DTX3 | 196403 | 2 | 0 | 34 | |
| GSE74704 | DTX3 | 196403 | 5 | 0 | 15 | |
| TCGA | DTX3 | 196403 | 14 | 10 | 72 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of DTX3:
Generating mutation plots.
Highly correlated genes for DTX3:
Showing top 20/818 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DTX3 | MISP | 0.780898 | 3 | 0 | 3 |
| DTX3 | TP53I13 | 0.756004 | 3 | 0 | 3 |
| DTX3 | IQUB | 0.730409 | 3 | 0 | 3 |
| DTX3 | ZBED1 | 0.721833 | 3 | 0 | 3 |
| DTX3 | ID2 | 0.721002 | 3 | 0 | 3 |
| DTX3 | PFN2 | 0.712519 | 3 | 0 | 3 |
| DTX3 | DHX37 | 0.710837 | 3 | 0 | 3 |
| DTX3 | RAB28 | 0.710543 | 3 | 0 | 3 |
| DTX3 | SOCS3 | 0.709224 | 3 | 0 | 3 |
| DTX3 | CORO6 | 0.704305 | 4 | 0 | 4 |
| DTX3 | MAP4 | 0.702985 | 3 | 0 | 3 |
| DTX3 | HSPA6 | 0.701049 | 3 | 0 | 3 |
| DTX3 | ABI2 | 0.699243 | 6 | 0 | 6 |
| DTX3 | ZBTB10 | 0.693749 | 4 | 0 | 4 |
| DTX3 | ESYT1 | 0.692506 | 3 | 0 | 3 |
| DTX3 | EXOC3 | 0.68651 | 3 | 0 | 3 |
| DTX3 | BBS4 | 0.686424 | 3 | 0 | 3 |
| DTX3 | CAND2 | 0.685891 | 5 | 0 | 4 |
| DTX3 | TTC7B | 0.683903 | 6 | 0 | 5 |
| DTX3 | CERCAM | 0.683002 | 3 | 0 | 3 |
For details and further investigation, click here
