| Full name: pre T cell antigen receptor alpha | Alias Symbol: PTA|PT-ALPHA | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 171558 | HGNC ID: HGNC:21290 | Ensembl Gene: ENSG00000171611 | OMIM ID: 606817 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PTCRA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of PTCRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTCRA | 171558 | 211252_x_at | -0.0890 | 0.6359 | |
| GSE20347 | PTCRA | 171558 | 211252_x_at | -0.0596 | 0.5954 | |
| GSE23400 | PTCRA | 171558 | 215492_x_at | -0.0819 | 0.0226 | |
| GSE26886 | PTCRA | 171558 | 211252_x_at | 0.2412 | 0.1341 | |
| GSE29001 | PTCRA | 171558 | 215492_x_at | -0.3692 | 0.0519 | |
| GSE38129 | PTCRA | 171558 | 215492_x_at | -0.2732 | 0.0169 | |
| GSE45670 | PTCRA | 171558 | 211252_x_at | -0.0736 | 0.4795 | |
| GSE53622 | PTCRA | 171558 | 83430 | 0.1778 | 0.0057 | |
| GSE53624 | PTCRA | 171558 | 83430 | 0.2852 | 0.0013 | |
| GSE63941 | PTCRA | 171558 | 211252_x_at | 0.4822 | 0.0005 | |
| GSE77861 | PTCRA | 171558 | 211252_x_at | 0.0323 | 0.7998 | |
| GSE97050 | PTCRA | 171558 | A_33_P3229918 | -0.0032 | 0.9917 | |
| TCGA | PTCRA | 171558 | RNAseq | 0.5663 | 0.5022 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTCRA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTCRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTCRA | 171558 | 7 | 0 | 23 | |
| GSE20123 | PTCRA | 171558 | 7 | 0 | 23 | |
| GSE43470 | PTCRA | 171558 | 6 | 0 | 37 | |
| GSE46452 | PTCRA | 171558 | 2 | 9 | 48 | |
| GSE47630 | PTCRA | 171558 | 8 | 4 | 28 | |
| GSE54993 | PTCRA | 171558 | 3 | 2 | 65 | |
| GSE54994 | PTCRA | 171558 | 11 | 6 | 36 | |
| GSE60625 | PTCRA | 171558 | 0 | 1 | 10 | |
| GSE74703 | PTCRA | 171558 | 6 | 0 | 30 | |
| GSE74704 | PTCRA | 171558 | 3 | 0 | 17 | |
| TCGA | PTCRA | 171558 | 20 | 13 | 63 |
Total number of gains: 73; Total number of losses: 35; Total Number of normals: 380.
Somatic mutations of PTCRA:
Generating mutation plots.
Highly correlated genes for PTCRA:
Showing top 20/901 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTCRA | MYBPH | 0.785083 | 4 | 0 | 4 |
| PTCRA | COL20A1 | 0.751172 | 3 | 0 | 3 |
| PTCRA | TMEM102 | 0.745126 | 4 | 0 | 4 |
| PTCRA | LHFPL5 | 0.744319 | 3 | 0 | 3 |
| PTCRA | OPTC | 0.742132 | 3 | 0 | 3 |
| PTCRA | RAB3IL1 | 0.73963 | 6 | 0 | 5 |
| PTCRA | CDH23 | 0.731426 | 3 | 0 | 3 |
| PTCRA | IL1F10 | 0.723836 | 3 | 0 | 3 |
| PTCRA | OR10W1 | 0.720466 | 3 | 0 | 3 |
| PTCRA | TRAPPC9 | 0.710999 | 4 | 0 | 3 |
| PTCRA | AMN | 0.70935 | 6 | 0 | 5 |
| PTCRA | FGF22 | 0.708821 | 3 | 0 | 3 |
| PTCRA | MIIP | 0.706268 | 3 | 0 | 3 |
| PTCRA | DHH | 0.701591 | 3 | 0 | 3 |
| PTCRA | MAP3K10 | 0.701198 | 7 | 0 | 6 |
| PTCRA | ADAP1 | 0.700109 | 5 | 0 | 5 |
| PTCRA | MAGEE2 | 0.699498 | 3 | 0 | 3 |
| PTCRA | IFNA10 | 0.699012 | 4 | 0 | 3 |
| PTCRA | LRRC46 | 0.697857 | 4 | 0 | 3 |
| PTCRA | RDH13 | 0.696139 | 3 | 0 | 3 |
For details and further investigation, click here
