| Full name: tenascin XB | Alias Symbol: TNXBS|XBS|XB | ||
| Type: protein-coding gene | Cytoband: 6p21.33-p21.32 | ||
| Entrez ID: 7148 | HGNC ID: HGNC:11976 | Ensembl Gene: ENSG00000168477 | OMIM ID: 600985 |
| Drug and gene relationship at DGIdb | |||
TNXB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of TNXB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNXB | 7148 | 217413_s_at | -0.1252 | 0.6252 | |
| GSE20347 | TNXB | 7148 | 217413_s_at | -0.0679 | 0.3795 | |
| GSE23400 | TNXB | 7148 | 217413_s_at | -0.0839 | 0.0102 | |
| GSE26886 | TNXB | 7148 | 217413_s_at | 0.1027 | 0.5776 | |
| GSE29001 | TNXB | 7148 | 217413_s_at | 0.0202 | 0.9110 | |
| GSE38129 | TNXB | 7148 | 217413_s_at | -0.0461 | 0.4366 | |
| GSE45670 | TNXB | 7148 | 217413_s_at | 0.0346 | 0.7295 | |
| GSE53622 | TNXB | 7148 | 21034 | -3.0897 | 0.0000 | |
| GSE53624 | TNXB | 7148 | 21034 | -2.1010 | 0.0000 | |
| GSE63941 | TNXB | 7148 | 217413_s_at | 0.0858 | 0.5403 | |
| GSE77861 | TNXB | 7148 | 217413_s_at | -0.1550 | 0.2012 | |
| GSE97050 | TNXB | 7148 | A_23_P156708 | -0.7223 | 0.1921 | |
| SRP007169 | TNXB | 7148 | RNAseq | -0.7391 | 0.1221 | |
| SRP064894 | TNXB | 7148 | RNAseq | -1.9734 | 0.0002 | |
| SRP133303 | TNXB | 7148 | RNAseq | -2.6178 | 0.0001 | |
| SRP159526 | TNXB | 7148 | RNAseq | -2.3952 | 0.0000 | |
| SRP193095 | TNXB | 7148 | RNAseq | -0.5266 | 0.2386 | |
| SRP219564 | TNXB | 7148 | RNAseq | -0.2969 | 0.7851 | |
| TCGA | TNXB | 7148 | RNAseq | -1.5218 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by TNXB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNXB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNXB | 7148 | 5 | 1 | 24 | |
| GSE20123 | TNXB | 7148 | 5 | 1 | 24 | |
| GSE43470 | TNXB | 7148 | 5 | 1 | 37 | |
| GSE46452 | TNXB | 7148 | 1 | 10 | 48 | |
| GSE47630 | TNXB | 7148 | 7 | 4 | 29 | |
| GSE54993 | TNXB | 7148 | 2 | 1 | 67 | |
| GSE54994 | TNXB | 7148 | 11 | 4 | 38 | |
| GSE60625 | TNXB | 7148 | 0 | 1 | 10 | |
| GSE74703 | TNXB | 7148 | 5 | 0 | 31 | |
| GSE74704 | TNXB | 7148 | 2 | 0 | 18 | |
| TCGA | TNXB | 7148 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of TNXB:
Generating mutation plots.
Highly correlated genes for TNXB:
Showing top 20/830 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNXB | PLAC9 | 0.805959 | 3 | 0 | 3 |
| TNXB | TDRD10 | 0.784596 | 3 | 0 | 3 |
| TNXB | PNPLA7 | 0.772081 | 3 | 0 | 3 |
| TNXB | CADM2 | 0.769885 | 3 | 0 | 3 |
| TNXB | CFD | 0.758155 | 3 | 0 | 3 |
| TNXB | GSN | 0.751252 | 3 | 0 | 3 |
| TNXB | ENPP7 | 0.750999 | 3 | 0 | 3 |
| TNXB | DUSP15 | 0.750814 | 4 | 0 | 4 |
| TNXB | SCGN | 0.747576 | 3 | 0 | 3 |
| TNXB | FAM189A2 | 0.745963 | 4 | 0 | 3 |
| TNXB | CDH23 | 0.745308 | 3 | 0 | 3 |
| TNXB | PDK4 | 0.743615 | 5 | 0 | 5 |
| TNXB | ATOH8 | 0.742141 | 4 | 0 | 3 |
| TNXB | CDH4 | 0.73876 | 3 | 0 | 3 |
| TNXB | RASL10B | 0.736552 | 3 | 0 | 3 |
| TNXB | ZDHHC15 | 0.734593 | 3 | 0 | 3 |
| TNXB | FAM163B | 0.733418 | 3 | 0 | 3 |
| TNXB | C7orf61 | 0.73285 | 3 | 0 | 3 |
| TNXB | OR10G8 | 0.726336 | 3 | 0 | 3 |
| TNXB | TMEFF2 | 0.724518 | 3 | 0 | 3 |
For details and further investigation, click here
