| Full name: DLC1 Rho GTPase activating protein | Alias Symbol: HP|ARHGAP7|STARD12|DLC-1|p122-RhoGAP | ||
| Type: protein-coding gene | Cytoband: 8p22 | ||
| Entrez ID: 10395 | HGNC ID: HGNC:2897 | Ensembl Gene: ENSG00000164741 | OMIM ID: 604258 |
| Drug and gene relationship at DGIdb | |||
Expression of DLC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLC1 | 10395 | 210762_s_at | -0.7790 | 0.3420 | |
| GSE20347 | DLC1 | 10395 | 210762_s_at | 0.0719 | 0.8438 | |
| GSE23400 | DLC1 | 10395 | 210762_s_at | -0.2565 | 0.0601 | |
| GSE26886 | DLC1 | 10395 | 210762_s_at | 0.9932 | 0.0375 | |
| GSE29001 | DLC1 | 10395 | 210762_s_at | -0.3198 | 0.2969 | |
| GSE38129 | DLC1 | 10395 | 210762_s_at | -0.6119 | 0.0700 | |
| GSE45670 | DLC1 | 10395 | 210762_s_at | -1.4302 | 0.0005 | |
| GSE53622 | DLC1 | 10395 | 68266 | -0.7358 | 0.0000 | |
| GSE53624 | DLC1 | 10395 | 68266 | -0.3951 | 0.0000 | |
| GSE63941 | DLC1 | 10395 | 210762_s_at | -5.4295 | 0.0015 | |
| GSE77861 | DLC1 | 10395 | 224822_at | 0.1218 | 0.4482 | |
| GSE97050 | DLC1 | 10395 | A_23_P112016 | -0.5298 | 0.1156 | |
| SRP007169 | DLC1 | 10395 | RNAseq | 1.8376 | 0.0002 | |
| SRP008496 | DLC1 | 10395 | RNAseq | 2.4903 | 0.0000 | |
| SRP064894 | DLC1 | 10395 | RNAseq | 0.1656 | 0.6768 | |
| SRP133303 | DLC1 | 10395 | RNAseq | -0.1948 | 0.4528 | |
| SRP159526 | DLC1 | 10395 | RNAseq | -0.0430 | 0.8894 | |
| SRP193095 | DLC1 | 10395 | RNAseq | 0.9569 | 0.0001 | |
| SRP219564 | DLC1 | 10395 | RNAseq | 0.2339 | 0.7936 | |
| TCGA | DLC1 | 10395 | RNAseq | -0.6056 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by DLC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLC1 | 10395 | 4 | 11 | 15 | |
| GSE20123 | DLC1 | 10395 | 4 | 11 | 15 | |
| GSE43470 | DLC1 | 10395 | 4 | 9 | 30 | |
| GSE46452 | DLC1 | 10395 | 12 | 14 | 33 | |
| GSE47630 | DLC1 | 10395 | 9 | 8 | 23 | |
| GSE54993 | DLC1 | 10395 | 3 | 14 | 53 | |
| GSE54994 | DLC1 | 10395 | 8 | 18 | 27 | |
| GSE60625 | DLC1 | 10395 | 3 | 0 | 8 | |
| GSE74703 | DLC1 | 10395 | 4 | 7 | 25 | |
| GSE74704 | DLC1 | 10395 | 3 | 7 | 10 | |
| TCGA | DLC1 | 10395 | 13 | 41 | 42 |
Total number of gains: 67; Total number of losses: 140; Total Number of normals: 281.
Somatic mutations of DLC1:
Generating mutation plots.
Highly correlated genes for DLC1:
Showing top 20/1118 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLC1 | FIBIN | 0.824084 | 4 | 0 | 4 |
| DLC1 | CLMP | 0.812987 | 4 | 0 | 4 |
| DLC1 | EIF4E3 | 0.787472 | 3 | 0 | 3 |
| DLC1 | MYADM | 0.771342 | 6 | 0 | 6 |
| DLC1 | STARD9 | 0.760433 | 6 | 0 | 6 |
| DLC1 | ITGA1 | 0.759851 | 9 | 0 | 9 |
| DLC1 | LIMS2 | 0.745491 | 9 | 0 | 8 |
| DLC1 | C11orf96 | 0.744094 | 5 | 0 | 5 |
| DLC1 | DCHS1 | 0.743889 | 9 | 0 | 8 |
| DLC1 | HSPB6 | 0.741082 | 6 | 0 | 6 |
| DLC1 | TMEM47 | 0.741002 | 10 | 0 | 9 |
| DLC1 | MRVI1 | 0.740298 | 7 | 0 | 7 |
| DLC1 | EPDR1 | 0.739009 | 5 | 0 | 4 |
| DLC1 | PEG3 | 0.734415 | 7 | 0 | 6 |
| DLC1 | AKAP12 | 0.733825 | 11 | 0 | 10 |
| DLC1 | VGLL3 | 0.733652 | 9 | 0 | 8 |
| DLC1 | MEOX2 | 0.73301 | 8 | 0 | 8 |
| DLC1 | MAP1A | 0.730917 | 8 | 0 | 7 |
| DLC1 | SYNC | 0.730532 | 7 | 0 | 6 |
| DLC1 | STARD13 | 0.730387 | 11 | 0 | 11 |
For details and further investigation, click here
