| Full name: A-kinase anchoring protein 12 | Alias Symbol: AKAP250|SSeCKS | ||
| Type: protein-coding gene | Cytoband: 6q25.1 | ||
| Entrez ID: 9590 | HGNC ID: HGNC:370 | Ensembl Gene: ENSG00000131016 | OMIM ID: 604698 |
| Drug and gene relationship at DGIdb | |||
Expression of AKAP12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP12 | 9590 | 210517_s_at | -1.7116 | 0.1011 | |
| GSE20347 | AKAP12 | 9590 | 210517_s_at | 0.1389 | 0.7012 | |
| GSE23400 | AKAP12 | 9590 | 210517_s_at | -0.3653 | 0.0287 | |
| GSE26886 | AKAP12 | 9590 | 227530_at | 1.6024 | 0.0027 | |
| GSE29001 | AKAP12 | 9590 | 210517_s_at | 0.0192 | 0.9682 | |
| GSE38129 | AKAP12 | 9590 | 210517_s_at | -0.4889 | 0.3862 | |
| GSE45670 | AKAP12 | 9590 | 210517_s_at | -2.7979 | 0.0001 | |
| GSE53622 | AKAP12 | 9590 | 27450 | -1.7624 | 0.0000 | |
| GSE53624 | AKAP12 | 9590 | 27450 | -1.2581 | 0.0000 | |
| GSE63941 | AKAP12 | 9590 | 210517_s_at | -3.5705 | 0.0172 | |
| GSE77861 | AKAP12 | 9590 | 210517_s_at | 1.0286 | 0.2910 | |
| GSE97050 | AKAP12 | 9590 | A_23_P111311 | -0.9067 | 0.1065 | |
| SRP007169 | AKAP12 | 9590 | RNAseq | 2.8836 | 0.0000 | |
| SRP008496 | AKAP12 | 9590 | RNAseq | 3.4808 | 0.0000 | |
| SRP064894 | AKAP12 | 9590 | RNAseq | -0.7938 | 0.0619 | |
| SRP133303 | AKAP12 | 9590 | RNAseq | -0.8025 | 0.0333 | |
| SRP159526 | AKAP12 | 9590 | RNAseq | -0.6992 | 0.1735 | |
| SRP193095 | AKAP12 | 9590 | RNAseq | 1.1212 | 0.0071 | |
| SRP219564 | AKAP12 | 9590 | RNAseq | -0.0445 | 0.9611 | |
| TCGA | AKAP12 | 9590 | RNAseq | -0.7256 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 4.
Survival by AKAP12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP12 | 9590 | 1 | 4 | 25 | |
| GSE20123 | AKAP12 | 9590 | 1 | 3 | 26 | |
| GSE43470 | AKAP12 | 9590 | 4 | 0 | 39 | |
| GSE46452 | AKAP12 | 9590 | 3 | 10 | 46 | |
| GSE47630 | AKAP12 | 9590 | 9 | 4 | 27 | |
| GSE54993 | AKAP12 | 9590 | 3 | 2 | 65 | |
| GSE54994 | AKAP12 | 9590 | 8 | 8 | 37 | |
| GSE60625 | AKAP12 | 9590 | 0 | 1 | 10 | |
| GSE74703 | AKAP12 | 9590 | 4 | 0 | 32 | |
| GSE74704 | AKAP12 | 9590 | 0 | 1 | 19 | |
| TCGA | AKAP12 | 9590 | 12 | 20 | 64 |
Total number of gains: 45; Total number of losses: 53; Total Number of normals: 390.
Somatic mutations of AKAP12:
Generating mutation plots.
Highly correlated genes for AKAP12:
Showing top 20/1062 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP12 | PLAC9 | 0.831107 | 4 | 0 | 4 |
| AKAP12 | SPARCL1 | 0.806505 | 8 | 0 | 8 |
| AKAP12 | C11orf96 | 0.801317 | 5 | 0 | 5 |
| AKAP12 | RBPMS2 | 0.794468 | 6 | 0 | 6 |
| AKAP12 | RASSF3 | 0.789822 | 4 | 0 | 4 |
| AKAP12 | MSRB3 | 0.789761 | 7 | 0 | 6 |
| AKAP12 | ITGA7 | 0.78931 | 7 | 0 | 7 |
| AKAP12 | MRVI1 | 0.787998 | 6 | 0 | 6 |
| AKAP12 | TCEAL6 | 0.787951 | 3 | 0 | 3 |
| AKAP12 | CYP21A2 | 0.787628 | 3 | 0 | 3 |
| AKAP12 | ZCCHC24 | 0.783345 | 10 | 0 | 10 |
| AKAP12 | CLEC3B | 0.782555 | 3 | 0 | 3 |
| AKAP12 | OGN | 0.781612 | 8 | 0 | 8 |
| AKAP12 | LINC00526 | 0.780947 | 3 | 0 | 3 |
| AKAP12 | MAGI2-AS3 | 0.770731 | 6 | 0 | 6 |
| AKAP12 | ABCA8 | 0.767291 | 8 | 0 | 8 |
| AKAP12 | XKR4 | 0.766314 | 5 | 0 | 5 |
| AKAP12 | PPP1R14A | 0.76544 | 6 | 0 | 6 |
| AKAP12 | CASQ2 | 0.761639 | 8 | 0 | 7 |
| AKAP12 | HSPB6 | 0.761066 | 6 | 0 | 6 |
For details and further investigation, click here
