| Full name: diencephalon/mesencephalon homeobox 1 | Alias Symbol: PAXB | ||
| Type: protein-coding gene | Cytoband: 1p33 | ||
| Entrez ID: 127343 | HGNC ID: HGNC:19026 | Ensembl Gene: ENSG00000197587 | OMIM ID: 607410 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DMBX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DMBX1 | 127343 | 234776_at | -0.0840 | 0.7750 | |
| GSE26886 | DMBX1 | 127343 | 234776_at | 0.0921 | 0.3020 | |
| GSE45670 | DMBX1 | 127343 | 234776_at | 0.0399 | 0.5849 | |
| GSE53622 | DMBX1 | 127343 | 27993 | 0.3774 | 0.0003 | |
| GSE53624 | DMBX1 | 127343 | 27993 | 0.6433 | 0.0000 | |
| GSE63941 | DMBX1 | 127343 | 234776_at | 0.1287 | 0.3493 | |
| GSE77861 | DMBX1 | 127343 | 234776_at | -0.1183 | 0.2251 | |
| GSE97050 | DMBX1 | 127343 | A_23_P500542 | -0.1785 | 0.6473 | |
| SRP133303 | DMBX1 | 127343 | RNAseq | 1.1175 | 0.0017 | |
| SRP219564 | DMBX1 | 127343 | RNAseq | 3.5480 | 0.0001 | |
| TCGA | DMBX1 | 127343 | RNAseq | 4.6166 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DMBX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DMBX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DMBX1 | 127343 | 4 | 3 | 23 | |
| GSE20123 | DMBX1 | 127343 | 4 | 2 | 24 | |
| GSE43470 | DMBX1 | 127343 | 5 | 1 | 37 | |
| GSE46452 | DMBX1 | 127343 | 2 | 1 | 56 | |
| GSE47630 | DMBX1 | 127343 | 8 | 4 | 28 | |
| GSE54993 | DMBX1 | 127343 | 0 | 1 | 69 | |
| GSE54994 | DMBX1 | 127343 | 11 | 2 | 40 | |
| GSE60625 | DMBX1 | 127343 | 0 | 0 | 11 | |
| GSE74703 | DMBX1 | 127343 | 4 | 1 | 31 | |
| GSE74704 | DMBX1 | 127343 | 2 | 0 | 18 | |
| TCGA | DMBX1 | 127343 | 10 | 17 | 69 |
Total number of gains: 50; Total number of losses: 32; Total Number of normals: 406.
Somatic mutations of DMBX1:
Generating mutation plots.
Highly correlated genes for DMBX1:
Showing all 19 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DMBX1 | RLBP1 | 0.72331 | 3 | 0 | 3 |
| DMBX1 | CCDC63 | 0.595872 | 3 | 0 | 3 |
| DMBX1 | DOK6 | 0.588324 | 3 | 0 | 3 |
| DMBX1 | PATE1 | 0.576869 | 3 | 0 | 3 |
| DMBX1 | FRMD1 | 0.561777 | 4 | 0 | 3 |
| DMBX1 | C5orf49 | 0.559845 | 3 | 0 | 3 |
| DMBX1 | EIF6 | 0.552315 | 3 | 0 | 3 |
| DMBX1 | SLC9A3 | 0.551435 | 4 | 0 | 3 |
| DMBX1 | C10orf53 | 0.551224 | 5 | 0 | 3 |
| DMBX1 | GPR17 | 0.550903 | 3 | 0 | 3 |
| DMBX1 | VGLL2 | 0.550583 | 5 | 0 | 3 |
| DMBX1 | CHRM4 | 0.537573 | 7 | 0 | 5 |
| DMBX1 | SLC25A48 | 0.536619 | 4 | 0 | 3 |
| DMBX1 | RPL34-AS1 | 0.53645 | 3 | 0 | 3 |
| DMBX1 | TACR3 | 0.532681 | 4 | 0 | 3 |
| DMBX1 | FFAR2 | 0.526637 | 4 | 0 | 3 |
| DMBX1 | RGR | 0.5181 | 5 | 0 | 3 |
| DMBX1 | TP73 | 0.515525 | 4 | 0 | 3 |
| DMBX1 | TMPRSS6 | 0.500072 | 6 | 0 | 3 |
For details and further investigation, click here
