| Full name: cholinergic receptor muscarinic 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 1132 | HGNC ID: HGNC:1953 | Ensembl Gene: ENSG00000180720 | OMIM ID: 118495 |
| Drug and gene relationship at DGIdb | |||
CHRM4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04725 | Cholinergic synapse | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of CHRM4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRM4 | 1132 | 221357_at | -0.1023 | 0.7513 | |
| GSE20347 | CHRM4 | 1132 | 221357_at | 0.0034 | 0.9737 | |
| GSE23400 | CHRM4 | 1132 | 221357_at | -0.1149 | 0.0006 | |
| GSE26886 | CHRM4 | 1132 | 221357_at | 0.0336 | 0.8146 | |
| GSE29001 | CHRM4 | 1132 | 221357_at | -0.0500 | 0.7060 | |
| GSE38129 | CHRM4 | 1132 | 221357_at | -0.0726 | 0.2579 | |
| GSE45670 | CHRM4 | 1132 | 221357_at | -0.1360 | 0.2183 | |
| GSE53622 | CHRM4 | 1132 | 71710 | 0.6226 | 0.0000 | |
| GSE53624 | CHRM4 | 1132 | 71710 | 0.8194 | 0.0000 | |
| GSE63941 | CHRM4 | 1132 | 221357_at | -0.0103 | 0.9524 | |
| GSE77861 | CHRM4 | 1132 | 221357_at | -0.1301 | 0.1223 | |
| GSE97050 | CHRM4 | 1132 | A_33_P3367850 | 0.0648 | 0.8474 | |
| TCGA | CHRM4 | 1132 | RNAseq | -0.8464 | 0.0200 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRM4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRM4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRM4 | 1132 | 3 | 7 | 20 | |
| GSE20123 | CHRM4 | 1132 | 3 | 6 | 21 | |
| GSE43470 | CHRM4 | 1132 | 2 | 5 | 36 | |
| GSE46452 | CHRM4 | 1132 | 8 | 5 | 46 | |
| GSE47630 | CHRM4 | 1132 | 3 | 9 | 28 | |
| GSE54993 | CHRM4 | 1132 | 3 | 0 | 67 | |
| GSE54994 | CHRM4 | 1132 | 1 | 10 | 42 | |
| GSE60625 | CHRM4 | 1132 | 0 | 0 | 11 | |
| GSE74703 | CHRM4 | 1132 | 2 | 2 | 32 | |
| GSE74704 | CHRM4 | 1132 | 2 | 4 | 14 | |
| TCGA | CHRM4 | 1132 | 15 | 19 | 62 |
Total number of gains: 42; Total number of losses: 67; Total Number of normals: 379.
Somatic mutations of CHRM4:
Generating mutation plots.
Highly correlated genes for CHRM4:
Showing top 20/449 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRM4 | RBP2 | 0.710894 | 3 | 0 | 3 |
| CHRM4 | KLHDC3 | 0.6828 | 3 | 0 | 3 |
| CHRM4 | ADAMTSL5 | 0.679848 | 4 | 0 | 4 |
| CHRM4 | TECRL | 0.665385 | 3 | 0 | 3 |
| CHRM4 | COL8A2 | 0.645906 | 3 | 0 | 3 |
| CHRM4 | GBF1 | 0.645838 | 3 | 0 | 3 |
| CHRM4 | CCDC87 | 0.645641 | 4 | 0 | 4 |
| CHRM4 | SLC25A27 | 0.643426 | 3 | 0 | 3 |
| CHRM4 | SLC25A35 | 0.641908 | 3 | 0 | 3 |
| CHRM4 | ZNF460 | 0.641566 | 6 | 0 | 4 |
| CHRM4 | ITGB3 | 0.639413 | 4 | 0 | 3 |
| CHRM4 | NEU3 | 0.637321 | 5 | 0 | 5 |
| CHRM4 | MYT1L | 0.631786 | 3 | 0 | 3 |
| CHRM4 | VGF | 0.630559 | 3 | 0 | 3 |
| CHRM4 | NPHS2 | 0.629635 | 6 | 0 | 5 |
| CHRM4 | ZNF480 | 0.627505 | 3 | 0 | 3 |
| CHRM4 | APOBR | 0.626736 | 4 | 0 | 4 |
| CHRM4 | OCM2 | 0.624116 | 4 | 0 | 4 |
| CHRM4 | ST6GALNAC4 | 0.622677 | 3 | 0 | 3 |
| CHRM4 | VAX2 | 0.620184 | 6 | 0 | 5 |
For details and further investigation, click here
