| Full name: eukaryotic translation initiation factor 6 | Alias Symbol: p27BBP|b(2)gcn | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 3692 | HGNC ID: HGNC:6159 | Ensembl Gene: ENSG00000242372 | OMIM ID: 602912 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF6 | 3692 | 210213_s_at | 0.2435 | 0.7142 | |
| GSE20347 | EIF6 | 3692 | 210213_s_at | -0.4958 | 0.0002 | |
| GSE23400 | EIF6 | 3692 | 210213_s_at | -0.2554 | 0.0065 | |
| GSE26886 | EIF6 | 3692 | 210213_s_at | -0.4456 | 0.0523 | |
| GSE29001 | EIF6 | 3692 | 210213_s_at | -0.2925 | 0.5256 | |
| GSE38129 | EIF6 | 3692 | 210213_s_at | -0.0545 | 0.7809 | |
| GSE45670 | EIF6 | 3692 | 210213_s_at | -0.0957 | 0.5834 | |
| GSE53622 | EIF6 | 3692 | 90388 | -0.0027 | 0.9823 | |
| GSE53624 | EIF6 | 3692 | 90388 | 0.0451 | 0.4860 | |
| GSE63941 | EIF6 | 3692 | 210213_s_at | 1.3341 | 0.0080 | |
| GSE77861 | EIF6 | 3692 | 210213_s_at | -0.2778 | 0.2020 | |
| GSE97050 | EIF6 | 3692 | A_23_P210939 | 0.2318 | 0.6450 | |
| SRP007169 | EIF6 | 3692 | RNAseq | -1.3925 | 0.0003 | |
| SRP008496 | EIF6 | 3692 | RNAseq | -1.1939 | 0.0000 | |
| SRP064894 | EIF6 | 3692 | RNAseq | 0.2424 | 0.4320 | |
| SRP133303 | EIF6 | 3692 | RNAseq | -0.3573 | 0.0116 | |
| SRP159526 | EIF6 | 3692 | RNAseq | -0.6975 | 0.0065 | |
| SRP193095 | EIF6 | 3692 | RNAseq | -0.5983 | 0.0000 | |
| SRP219564 | EIF6 | 3692 | RNAseq | -0.2475 | 0.5722 | |
| TCGA | EIF6 | 3692 | RNAseq | 0.1977 | 0.0012 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by EIF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF6 | 3692 | 16 | 0 | 14 | |
| GSE20123 | EIF6 | 3692 | 16 | 0 | 14 | |
| GSE43470 | EIF6 | 3692 | 13 | 0 | 30 | |
| GSE46452 | EIF6 | 3692 | 29 | 0 | 30 | |
| GSE47630 | EIF6 | 3692 | 25 | 0 | 15 | |
| GSE54993 | EIF6 | 3692 | 0 | 17 | 53 | |
| GSE54994 | EIF6 | 3692 | 24 | 0 | 29 | |
| GSE60625 | EIF6 | 3692 | 0 | 0 | 11 | |
| GSE74703 | EIF6 | 3692 | 11 | 0 | 25 | |
| GSE74704 | EIF6 | 3692 | 11 | 0 | 9 | |
| TCGA | EIF6 | 3692 | 49 | 3 | 44 |
Total number of gains: 194; Total number of losses: 20; Total Number of normals: 274.
Somatic mutations of EIF6:
Generating mutation plots.
Highly correlated genes for EIF6:
Showing top 20/687 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF6 | SLC22A23 | 0.721455 | 3 | 0 | 3 |
| EIF6 | PDIK1L | 0.696583 | 3 | 0 | 3 |
| EIF6 | HM13 | 0.684952 | 7 | 0 | 7 |
| EIF6 | CLIC1 | 0.6829 | 9 | 0 | 8 |
| EIF6 | PRDX5 | 0.682801 | 5 | 0 | 4 |
| EIF6 | NSDHL | 0.681245 | 7 | 0 | 6 |
| EIF6 | SLC25A39 | 0.680082 | 7 | 0 | 6 |
| EIF6 | EIF3F | 0.674053 | 3 | 0 | 3 |
| EIF6 | PTBP3 | 0.671422 | 6 | 0 | 5 |
| EIF6 | NAA20 | 0.668276 | 6 | 0 | 6 |
| EIF6 | GID8 | 0.662983 | 10 | 0 | 8 |
| EIF6 | TSEN54 | 0.661012 | 4 | 0 | 4 |
| EIF6 | CAPNS2 | 0.656372 | 3 | 0 | 3 |
| EIF6 | ZBTB9 | 0.65416 | 3 | 0 | 3 |
| EIF6 | DDOST | 0.653797 | 3 | 0 | 3 |
| EIF6 | FDXR | 0.649723 | 7 | 0 | 6 |
| EIF6 | ASL | 0.644113 | 8 | 0 | 8 |
| EIF6 | PPP1R14B | 0.642892 | 4 | 0 | 4 |
| EIF6 | E2F2 | 0.642121 | 5 | 0 | 4 |
| EIF6 | GJB5 | 0.640787 | 10 | 0 | 8 |
For details and further investigation, click here
