| Full name: tumor protein p73 | Alias Symbol: P73 | ||
| Type: protein-coding gene | Cytoband: 1p36.32 | ||
| Entrez ID: 7161 | HGNC ID: HGNC:12003 | Ensembl Gene: ENSG00000078900 | OMIM ID: 601990 |
| Drug and gene relationship at DGIdb | |||
TP73 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway | |
| hsa04390 | Hippo signaling pathway | |
| hsa04722 | Neurotrophin signaling pathway |
Expression of TP73:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TP73 | 7161 | 1554379_a_at | 0.1664 | 0.6662 | |
| GSE20347 | TP73 | 7161 | 220804_s_at | -0.0224 | 0.8347 | |
| GSE23400 | TP73 | 7161 | 220804_s_at | 0.0019 | 0.9685 | |
| GSE26886 | TP73 | 7161 | 1554379_a_at | 0.2174 | 0.1015 | |
| GSE29001 | TP73 | 7161 | 220804_s_at | -0.1810 | 0.1492 | |
| GSE38129 | TP73 | 7161 | 220804_s_at | -0.1303 | 0.1965 | |
| GSE45670 | TP73 | 7161 | 232546_at | 0.4251 | 0.0263 | |
| GSE53622 | TP73 | 7161 | 38080 | 0.5909 | 0.0000 | |
| GSE53624 | TP73 | 7161 | 114073 | 0.3032 | 0.0055 | |
| GSE63941 | TP73 | 7161 | 1554379_a_at | 0.6023 | 0.0420 | |
| GSE77861 | TP73 | 7161 | 1554379_a_at | -0.1129 | 0.2292 | |
| GSE97050 | TP73 | 7161 | A_24_P413470 | 0.9798 | 0.0916 | |
| SRP007169 | TP73 | 7161 | RNAseq | 0.2973 | 0.6622 | |
| SRP008496 | TP73 | 7161 | RNAseq | 0.0438 | 0.9139 | |
| SRP064894 | TP73 | 7161 | RNAseq | 0.5871 | 0.1283 | |
| SRP133303 | TP73 | 7161 | RNAseq | 0.2464 | 0.4352 | |
| SRP159526 | TP73 | 7161 | RNAseq | 1.0603 | 0.1232 | |
| SRP193095 | TP73 | 7161 | RNAseq | 0.4346 | 0.1314 | |
| SRP219564 | TP73 | 7161 | RNAseq | 0.5437 | 0.4330 | |
| TCGA | TP73 | 7161 | RNAseq | 1.4578 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TP73 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TP73:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TP73 | 7161 | 4 | 6 | 20 | |
| GSE20123 | TP73 | 7161 | 4 | 5 | 21 | |
| GSE43470 | TP73 | 7161 | 3 | 5 | 35 | |
| GSE46452 | TP73 | 7161 | 7 | 1 | 51 | |
| GSE47630 | TP73 | 7161 | 8 | 4 | 28 | |
| GSE54993 | TP73 | 7161 | 3 | 2 | 65 | |
| GSE54994 | TP73 | 7161 | 14 | 3 | 36 | |
| GSE60625 | TP73 | 7161 | 0 | 0 | 11 | |
| GSE74703 | TP73 | 7161 | 3 | 3 | 30 | |
| GSE74704 | TP73 | 7161 | 4 | 0 | 16 | |
| TCGA | TP73 | 7161 | 14 | 20 | 62 |
Total number of gains: 64; Total number of losses: 49; Total Number of normals: 375.
Somatic mutations of TP73:
Generating mutation plots.
Highly correlated genes for TP73:
Showing top 20/589 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TP73 | CA6 | 0.77645 | 4 | 0 | 4 |
| TP73 | TULP2 | 0.774345 | 3 | 0 | 3 |
| TP73 | TMEM179 | 0.749583 | 4 | 0 | 4 |
| TP73 | GPR150 | 0.745286 | 4 | 0 | 3 |
| TP73 | CD300LG | 0.744912 | 3 | 0 | 3 |
| TP73 | ABCC2 | 0.743327 | 3 | 0 | 3 |
| TP73 | ZAN | 0.741103 | 3 | 0 | 3 |
| TP73 | ONECUT1 | 0.740809 | 3 | 0 | 3 |
| TP73 | MEGF11 | 0.734609 | 4 | 0 | 3 |
| TP73 | CLTCL1 | 0.730085 | 3 | 0 | 3 |
| TP73 | FAM151A | 0.728964 | 3 | 0 | 3 |
| TP73 | MAGEA8 | 0.724091 | 3 | 0 | 3 |
| TP73 | CHRD | 0.721747 | 4 | 0 | 4 |
| TP73 | ARL4D | 0.713034 | 3 | 0 | 3 |
| TP73 | ANKRD33 | 0.712047 | 3 | 0 | 3 |
| TP73 | LRRC72 | 0.711745 | 3 | 0 | 3 |
| TP73 | SPACA3 | 0.710353 | 4 | 0 | 4 |
| TP73 | PLA2G2F | 0.710257 | 4 | 0 | 3 |
| TP73 | BSND | 0.706389 | 3 | 0 | 3 |
| TP73 | GALNT9 | 0.704082 | 3 | 0 | 3 |
For details and further investigation, click here
