| Full name: docking protein 6 | Alias Symbol: MGC20785|HsT3226 | ||
| Type: protein-coding gene | Cytoband: 18q22.2 | ||
| Entrez ID: 220164 | HGNC ID: HGNC:28301 | Ensembl Gene: ENSG00000206052 | OMIM ID: 611402 |
| Drug and gene relationship at DGIdb | |||
Expression of DOK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOK6 | 220164 | 236290_at | -0.1361 | 0.6777 | |
| GSE26886 | DOK6 | 220164 | 236290_at | 0.3290 | 0.0240 | |
| GSE45670 | DOK6 | 220164 | 236290_at | -0.3490 | 0.0013 | |
| GSE53622 | DOK6 | 220164 | 24932 | 0.0843 | 0.5935 | |
| GSE53624 | DOK6 | 220164 | 24932 | 0.5297 | 0.0000 | |
| GSE63941 | DOK6 | 220164 | 236290_at | -2.7295 | 0.0000 | |
| GSE77861 | DOK6 | 220164 | 236290_at | -0.0480 | 0.7949 | |
| GSE97050 | DOK6 | 220164 | A_32_P160561 | -0.0900 | 0.7585 | |
| SRP007169 | DOK6 | 220164 | RNAseq | 1.3692 | 0.1467 | |
| SRP133303 | DOK6 | 220164 | RNAseq | 0.2362 | 0.3952 | |
| SRP159526 | DOK6 | 220164 | RNAseq | 0.0864 | 0.8862 | |
| SRP219564 | DOK6 | 220164 | RNAseq | 0.0909 | 0.8827 | |
| TCGA | DOK6 | 220164 | RNAseq | -0.4293 | 0.1053 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DOK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOK6 | 220164 | 0 | 10 | 20 | |
| GSE20123 | DOK6 | 220164 | 0 | 10 | 20 | |
| GSE43470 | DOK6 | 220164 | 0 | 8 | 35 | |
| GSE46452 | DOK6 | 220164 | 1 | 26 | 32 | |
| GSE47630 | DOK6 | 220164 | 5 | 21 | 14 | |
| GSE54993 | DOK6 | 220164 | 9 | 0 | 61 | |
| GSE54994 | DOK6 | 220164 | 2 | 18 | 33 | |
| GSE60625 | DOK6 | 220164 | 0 | 4 | 7 | |
| GSE74703 | DOK6 | 220164 | 0 | 8 | 28 | |
| GSE74704 | DOK6 | 220164 | 0 | 8 | 12 | |
| TCGA | DOK6 | 220164 | 5 | 47 | 44 |
Total number of gains: 22; Total number of losses: 160; Total Number of normals: 306.
Somatic mutations of DOK6:
Generating mutation plots.
Highly correlated genes for DOK6:
Showing top 20/707 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOK6 | IL33 | 0.889862 | 3 | 0 | 3 |
| DOK6 | XYLT1 | 0.810287 | 3 | 0 | 3 |
| DOK6 | GYPC | 0.782199 | 4 | 0 | 4 |
| DOK6 | NTAN1 | 0.770762 | 3 | 0 | 3 |
| DOK6 | TK2 | 0.770439 | 3 | 0 | 3 |
| DOK6 | SCARA3 | 0.765029 | 3 | 0 | 3 |
| DOK6 | PEG3 | 0.761041 | 4 | 0 | 4 |
| DOK6 | ASPA | 0.760671 | 4 | 0 | 4 |
| DOK6 | SMPD1 | 0.755931 | 4 | 0 | 3 |
| DOK6 | WNT6 | 0.754978 | 3 | 0 | 3 |
| DOK6 | DZIP1L | 0.74973 | 3 | 0 | 3 |
| DOK6 | S1PR1 | 0.748655 | 4 | 0 | 3 |
| DOK6 | ANGPTL4 | 0.744262 | 3 | 0 | 3 |
| DOK6 | CNTLN | 0.740786 | 3 | 0 | 3 |
| DOK6 | EDNRB | 0.740493 | 4 | 0 | 3 |
| DOK6 | PDE5A | 0.737563 | 4 | 0 | 4 |
| DOK6 | TMEM100 | 0.737325 | 3 | 0 | 3 |
| DOK6 | PPM1D | 0.730868 | 4 | 0 | 3 |
| DOK6 | C11orf96 | 0.728772 | 4 | 0 | 4 |
| DOK6 | LRRK2 | 0.727683 | 5 | 0 | 5 |
For details and further investigation, click here
