DPH6

 

Full name: diphthamine biosynthesis 6 Alias Symbol: MGC14798
Type: protein-coding gene Cytoband: 15q14
Entrez ID: 89978 HGNC ID: HGNC:30543 Ensembl Gene: ENSG00000134146 OMIM ID: 618391
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DPH6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DPH6 89978 238662_at -0.1993 0.7843
GSE26886 DPH6 89978 238662_at 0.2906 0.2151
GSE45670 DPH6 89978 238662_at 0.0409 0.8620
GSE53622 DPH6 89978 7861 0.4086 0.0000
GSE53624 DPH6 89978 7861 0.1029 0.2544
GSE63941 DPH6 89978 238662_at 1.2662 0.0194
GSE77861 DPH6 89978 238662_at -0.2220 0.5336
SRP007169 DPH6 89978 RNAseq 0.3149 0.5242
SRP064894 DPH6 89978 RNAseq -0.2052 0.3166
SRP133303 DPH6 89978 RNAseq 0.2004 0.3095
SRP159526 DPH6 89978 RNAseq -0.0399 0.9272
SRP193095 DPH6 89978 RNAseq -0.0934 0.2900
SRP219564 DPH6 89978 RNAseq -0.3005 0.2976

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DPH6 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of DPH6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DPH6 89978 3 6 21
GSE20123 DPH6 89978 3 6 21
GSE43470 DPH6 89978 4 4 35
GSE46452 DPH6 89978 3 7 49
GSE47630 DPH6 89978 8 11 21
GSE54993 DPH6 89978 4 6 60
GSE54994 DPH6 89978 5 7 41
GSE60625 DPH6 89978 4 0 7
GSE74703 DPH6 89978 4 3 29
GSE74704 DPH6 89978 2 5 13
TCGA DPH6 89978 11 19 66

Total number of gains: 51; Total number of losses: 74; Total Number of normals: 363.  

 

Somatic mutations of DPH6:

 

Generating mutation plots.

 

Highly correlated genes for DPH6:

 

Showing all 12 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DPH6FGFBP10.701906303
DPH6VSNL10.658975303
DPH6MRPL460.657352303
DPH6GOT10.616241303
DPH6PGAP20.599253303
DPH6PARN0.572721303
DPH6AQR0.568543503
DPH6LRRC280.546183403
DPH6MRPL570.539391503
DPH6HOGA10.527119403
DPH6TUBGCP40.526154503
DPH6HOMER20.518706303

For details and further investigation, click here