| Full name: mitochondrial ribosomal protein L57 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q12.11 | ||
| Entrez ID: 78988 | HGNC ID: HGNC:14514 | Ensembl Gene: ENSG00000173141 | OMIM ID: 611997 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL57:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL57 | 78988 | 204386_s_at | -0.1747 | 0.6327 | |
| GSE20347 | MRPL57 | 78988 | 204386_s_at | -0.1977 | 0.1895 | |
| GSE23400 | MRPL57 | 78988 | 204386_s_at | 0.1543 | 0.0189 | |
| GSE26886 | MRPL57 | 78988 | 204386_s_at | 0.9945 | 0.0000 | |
| GSE29001 | MRPL57 | 78988 | 204386_s_at | 0.0710 | 0.8208 | |
| GSE38129 | MRPL57 | 78988 | 204386_s_at | -0.1156 | 0.3735 | |
| GSE45670 | MRPL57 | 78988 | 204386_s_at | 0.1573 | 0.1109 | |
| GSE53622 | MRPL57 | 78988 | 132234 | 0.3576 | 0.0001 | |
| GSE53624 | MRPL57 | 78988 | 132234 | 0.3400 | 0.0000 | |
| GSE63941 | MRPL57 | 78988 | 204386_s_at | 0.4885 | 0.1275 | |
| GSE77861 | MRPL57 | 78988 | 204386_s_at | -0.1633 | 0.5042 | |
| SRP007169 | MRPL57 | 78988 | RNAseq | -1.1038 | 0.0022 | |
| SRP008496 | MRPL57 | 78988 | RNAseq | -0.8954 | 0.0000 | |
| SRP064894 | MRPL57 | 78988 | RNAseq | 0.1813 | 0.5523 | |
| SRP133303 | MRPL57 | 78988 | RNAseq | -0.0810 | 0.6207 | |
| SRP159526 | MRPL57 | 78988 | RNAseq | -0.3939 | 0.0261 | |
| SRP193095 | MRPL57 | 78988 | RNAseq | -0.4684 | 0.0002 | |
| SRP219564 | MRPL57 | 78988 | RNAseq | -0.3335 | 0.2700 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MRPL57 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of MRPL57:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL57 | 78988 | 1 | 14 | 15 | |
| GSE20123 | MRPL57 | 78988 | 1 | 13 | 16 | |
| GSE43470 | MRPL57 | 78988 | 2 | 13 | 28 | |
| GSE46452 | MRPL57 | 78988 | 0 | 33 | 26 | |
| GSE47630 | MRPL57 | 78988 | 3 | 26 | 11 | |
| GSE54993 | MRPL57 | 78988 | 11 | 2 | 57 | |
| GSE54994 | MRPL57 | 78988 | 1 | 13 | 39 | |
| GSE60625 | MRPL57 | 78988 | 0 | 3 | 8 | |
| GSE74703 | MRPL57 | 78988 | 2 | 10 | 24 | |
| GSE74704 | MRPL57 | 78988 | 0 | 11 | 9 |
Total number of gains: 21; Total number of losses: 138; Total Number of normals: 233.
Somatic mutations of MRPL57:
Generating mutation plots.
Highly correlated genes for MRPL57:
Showing top 20/49 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL57 | BAALC | 0.745261 | 3 | 0 | 3 |
| MRPL57 | LINC00671 | 0.702099 | 3 | 0 | 3 |
| MRPL57 | FBRSL1 | 0.695813 | 3 | 0 | 3 |
| MRPL57 | ERAL1 | 0.674358 | 3 | 0 | 3 |
| MRPL57 | USP51 | 0.662536 | 3 | 0 | 3 |
| MRPL57 | SLC38A6 | 0.656289 | 4 | 0 | 3 |
| MRPL57 | SYCN | 0.654852 | 3 | 0 | 3 |
| MRPL57 | CPLX2 | 0.639948 | 3 | 0 | 3 |
| MRPL57 | CCDC154 | 0.637719 | 3 | 0 | 3 |
| MRPL57 | TMEM63B | 0.6306 | 3 | 0 | 3 |
| MRPL57 | THNSL2 | 0.618366 | 3 | 0 | 3 |
| MRPL57 | LINC00917 | 0.6164 | 4 | 0 | 3 |
| MRPL57 | TIGD1 | 0.612086 | 4 | 0 | 3 |
| MRPL57 | EIF3M | 0.611403 | 4 | 0 | 3 |
| MRPL57 | KDM8 | 0.607689 | 3 | 0 | 3 |
| MRPL57 | FAM222A-AS1 | 0.606435 | 3 | 0 | 3 |
| MRPL57 | SORCS3 | 0.606178 | 3 | 0 | 3 |
| MRPL57 | TNFAIP8L1 | 0.600669 | 5 | 0 | 3 |
| MRPL57 | RHBDD3 | 0.597948 | 3 | 0 | 3 |
| MRPL57 | CORO6 | 0.595385 | 3 | 0 | 3 |
For details and further investigation, click here
