| Full name: poly(A)-specific ribonuclease | Alias Symbol: DAN | ||
| Type: protein-coding gene | Cytoband: 16p13.12 | ||
| Entrez ID: 5073 | HGNC ID: HGNC:8609 | Ensembl Gene: ENSG00000140694 | OMIM ID: 604212 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PARN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARN | 5073 | 203905_at | 0.2037 | 0.6817 | |
| GSE20347 | PARN | 5073 | 203905_at | 0.4635 | 0.0005 | |
| GSE23400 | PARN | 5073 | 203905_at | 0.4408 | 0.0000 | |
| GSE26886 | PARN | 5073 | 203905_at | -0.0595 | 0.8013 | |
| GSE29001 | PARN | 5073 | 203905_at | 0.7290 | 0.0132 | |
| GSE38129 | PARN | 5073 | 203905_at | 0.4634 | 0.0001 | |
| GSE45670 | PARN | 5073 | 203905_at | 0.3538 | 0.0353 | |
| GSE53622 | PARN | 5073 | 39520 | 0.6544 | 0.0000 | |
| GSE53624 | PARN | 5073 | 39520 | 0.7235 | 0.0000 | |
| GSE63941 | PARN | 5073 | 203905_at | 0.4087 | 0.0672 | |
| GSE77861 | PARN | 5073 | 203905_at | 0.5965 | 0.0492 | |
| GSE97050 | PARN | 5073 | A_32_P133244 | 0.2546 | 0.2526 | |
| SRP007169 | PARN | 5073 | RNAseq | 0.2443 | 0.4684 | |
| SRP008496 | PARN | 5073 | RNAseq | 0.4001 | 0.0421 | |
| SRP064894 | PARN | 5073 | RNAseq | 0.4956 | 0.0001 | |
| SRP133303 | PARN | 5073 | RNAseq | 0.6936 | 0.0000 | |
| SRP159526 | PARN | 5073 | RNAseq | 0.3836 | 0.1564 | |
| SRP193095 | PARN | 5073 | RNAseq | 0.3940 | 0.0000 | |
| SRP219564 | PARN | 5073 | RNAseq | 0.5223 | 0.0766 | |
| TCGA | PARN | 5073 | RNAseq | 0.1348 | 0.0064 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PARN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARN | 5073 | 5 | 4 | 21 | |
| GSE20123 | PARN | 5073 | 5 | 3 | 22 | |
| GSE43470 | PARN | 5073 | 3 | 3 | 37 | |
| GSE46452 | PARN | 5073 | 38 | 1 | 20 | |
| GSE47630 | PARN | 5073 | 13 | 7 | 20 | |
| GSE54993 | PARN | 5073 | 3 | 5 | 62 | |
| GSE54994 | PARN | 5073 | 5 | 10 | 38 | |
| GSE60625 | PARN | 5073 | 4 | 1 | 6 | |
| GSE74703 | PARN | 5073 | 3 | 2 | 31 | |
| GSE74704 | PARN | 5073 | 2 | 1 | 17 | |
| TCGA | PARN | 5073 | 20 | 11 | 65 |
Total number of gains: 101; Total number of losses: 48; Total Number of normals: 339.
Somatic mutations of PARN:
Generating mutation plots.
Highly correlated genes for PARN:
Showing top 20/996 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARN | FXR2 | 0.727074 | 3 | 0 | 3 |
| PARN | AEBP2 | 0.705141 | 3 | 0 | 3 |
| PARN | C21orf91 | 0.689245 | 3 | 0 | 3 |
| PARN | GPN1 | 0.675806 | 6 | 0 | 5 |
| PARN | RNPS1 | 0.673443 | 12 | 0 | 11 |
| PARN | TRAF7 | 0.668682 | 5 | 0 | 4 |
| PARN | DIP2B | 0.666477 | 4 | 0 | 4 |
| PARN | NFATC3 | 0.664219 | 8 | 0 | 7 |
| PARN | RILPL2 | 0.659658 | 3 | 0 | 3 |
| PARN | CDKN2D | 0.659033 | 4 | 0 | 3 |
| PARN | POLR2J | 0.658979 | 5 | 0 | 4 |
| PARN | LSM4 | 0.657982 | 7 | 0 | 7 |
| PARN | XPO6 | 0.655812 | 11 | 0 | 9 |
| PARN | EIF2AK3 | 0.654238 | 3 | 0 | 3 |
| PARN | PALB2 | 0.653273 | 10 | 0 | 8 |
| PARN | SNRPB2 | 0.648272 | 8 | 0 | 6 |
| PARN | HPS3 | 0.643379 | 4 | 0 | 3 |
| PARN | GMPS | 0.643006 | 9 | 0 | 8 |
| PARN | SETD1A | 0.642866 | 4 | 0 | 4 |
| PARN | TAS2R43 | 0.642316 | 3 | 0 | 3 |
For details and further investigation, click here
