| Full name: 4-hydroxy-2-oxoglutarate aldolase 1 | Alias Symbol: FLJ37472|DHDPS2|NPL2 | ||
| Type: protein-coding gene | Cytoband: 10q24.2 | ||
| Entrez ID: 112817 | HGNC ID: HGNC:25155 | Ensembl Gene: ENSG00000241935 | OMIM ID: 613597 |
| Drug and gene relationship at DGIdb | |||
Expression of HOGA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOGA1 | 112817 | 239093_at | -0.1172 | 0.8845 | |
| GSE26886 | HOGA1 | 112817 | 239093_at | 0.3539 | 0.3626 | |
| GSE45670 | HOGA1 | 112817 | 239093_at | -0.0745 | 0.7339 | |
| GSE53622 | HOGA1 | 112817 | 77365 | -0.7122 | 0.0002 | |
| GSE53624 | HOGA1 | 112817 | 77365 | -0.8329 | 0.0000 | |
| GSE63941 | HOGA1 | 112817 | 239093_at | 0.9250 | 0.2100 | |
| GSE77861 | HOGA1 | 112817 | 239093_at | 0.0251 | 0.8332 | |
| GSE97050 | HOGA1 | 112817 | A_33_P3249076 | -0.1536 | 0.6159 | |
| SRP007169 | HOGA1 | 112817 | RNAseq | -0.3319 | 0.6518 | |
| SRP064894 | HOGA1 | 112817 | RNAseq | -0.3319 | 0.2378 | |
| SRP133303 | HOGA1 | 112817 | RNAseq | -0.0797 | 0.7483 | |
| SRP159526 | HOGA1 | 112817 | RNAseq | 0.5074 | 0.4594 | |
| SRP193095 | HOGA1 | 112817 | RNAseq | 0.1632 | 0.3688 | |
| SRP219564 | HOGA1 | 112817 | RNAseq | -0.3260 | 0.4778 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HOGA1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of HOGA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOGA1 | 112817 | 1 | 8 | 21 | |
| GSE20123 | HOGA1 | 112817 | 1 | 7 | 22 | |
| GSE43470 | HOGA1 | 112817 | 0 | 7 | 36 | |
| GSE46452 | HOGA1 | 112817 | 0 | 11 | 48 | |
| GSE47630 | HOGA1 | 112817 | 2 | 14 | 24 | |
| GSE54993 | HOGA1 | 112817 | 8 | 0 | 62 | |
| GSE54994 | HOGA1 | 112817 | 2 | 11 | 40 | |
| GSE60625 | HOGA1 | 112817 | 0 | 0 | 11 | |
| GSE74703 | HOGA1 | 112817 | 0 | 5 | 31 | |
| GSE74704 | HOGA1 | 112817 | 0 | 4 | 16 | |
| TCGA | HOGA1 | 112817 | 5 | 28 | 63 |
Total number of gains: 19; Total number of losses: 95; Total Number of normals: 374.
Somatic mutations of HOGA1:
Generating mutation plots.
Highly correlated genes for HOGA1:
Showing top 20/27 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOGA1 | DCUN1D1 | 0.838502 | 3 | 0 | 3 |
| HOGA1 | SLC35G1 | 0.729616 | 3 | 0 | 3 |
| HOGA1 | ACAT2 | 0.717547 | 3 | 0 | 3 |
| HOGA1 | BHMT | 0.709205 | 3 | 0 | 3 |
| HOGA1 | RCCD1 | 0.708269 | 3 | 0 | 3 |
| HOGA1 | ZNF624 | 0.700727 | 3 | 0 | 3 |
| HOGA1 | CYP2S1 | 0.671632 | 3 | 0 | 3 |
| HOGA1 | MID1 | 0.670565 | 3 | 0 | 3 |
| HOGA1 | CCDC122 | 0.653844 | 3 | 0 | 3 |
| HOGA1 | GIGYF2 | 0.644134 | 3 | 0 | 3 |
| HOGA1 | DHRS7B | 0.637572 | 3 | 0 | 3 |
| HOGA1 | RHBDL1 | 0.617385 | 4 | 0 | 3 |
| HOGA1 | ZNF629 | 0.616304 | 3 | 0 | 3 |
| HOGA1 | LINC00942 | 0.61292 | 3 | 0 | 3 |
| HOGA1 | IVD | 0.599992 | 5 | 0 | 3 |
| HOGA1 | KRTAP4-1 | 0.594988 | 4 | 0 | 3 |
| HOGA1 | SOSTDC1 | 0.588411 | 3 | 0 | 3 |
| HOGA1 | CCL17 | 0.585492 | 4 | 0 | 3 |
| HOGA1 | FLRT1 | 0.581217 | 3 | 0 | 3 |
| HOGA1 | NCR1 | 0.562196 | 4 | 0 | 3 |
For details and further investigation, click here
