| Full name: leucine rich repeat containing 28 | Alias Symbol: MGC24976|FLJ34269|FLJ45242 | ||
| Type: protein-coding gene | Cytoband: 15q26.3 | ||
| Entrez ID: 123355 | HGNC ID: HGNC:28355 | Ensembl Gene: ENSG00000168904 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LRRC28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC28 | 123355 | 227423_at | -0.0585 | 0.8920 | |
| GSE26886 | LRRC28 | 123355 | 227423_at | -0.2804 | 0.1502 | |
| GSE45670 | LRRC28 | 123355 | 227423_at | 0.0489 | 0.7423 | |
| GSE53622 | LRRC28 | 123355 | 29210 | 0.1721 | 0.0120 | |
| GSE53624 | LRRC28 | 123355 | 16876 | -0.1149 | 0.1784 | |
| GSE63941 | LRRC28 | 123355 | 227423_at | 0.7074 | 0.0613 | |
| GSE77861 | LRRC28 | 123355 | 227423_at | -0.3030 | 0.1183 | |
| GSE97050 | LRRC28 | 123355 | A_33_P3301034 | -0.0915 | 0.7101 | |
| SRP007169 | LRRC28 | 123355 | RNAseq | -0.7564 | 0.0607 | |
| SRP008496 | LRRC28 | 123355 | RNAseq | -0.9266 | 0.0009 | |
| SRP064894 | LRRC28 | 123355 | RNAseq | -0.0937 | 0.5184 | |
| SRP133303 | LRRC28 | 123355 | RNAseq | -0.0880 | 0.5539 | |
| SRP159526 | LRRC28 | 123355 | RNAseq | 0.0035 | 0.9879 | |
| SRP193095 | LRRC28 | 123355 | RNAseq | -0.2772 | 0.0039 | |
| SRP219564 | LRRC28 | 123355 | RNAseq | -0.2875 | 0.3664 | |
| TCGA | LRRC28 | 123355 | RNAseq | -0.0814 | 0.2016 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LRRC28 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC28 | 123355 | 7 | 1 | 22 | |
| GSE20123 | LRRC28 | 123355 | 7 | 1 | 22 | |
| GSE43470 | LRRC28 | 123355 | 8 | 3 | 32 | |
| GSE46452 | LRRC28 | 123355 | 3 | 7 | 49 | |
| GSE47630 | LRRC28 | 123355 | 9 | 10 | 21 | |
| GSE54993 | LRRC28 | 123355 | 4 | 7 | 59 | |
| GSE54994 | LRRC28 | 123355 | 9 | 7 | 37 | |
| GSE60625 | LRRC28 | 123355 | 4 | 0 | 7 | |
| GSE74703 | LRRC28 | 123355 | 6 | 3 | 27 | |
| GSE74704 | LRRC28 | 123355 | 3 | 2 | 15 | |
| TCGA | LRRC28 | 123355 | 18 | 12 | 66 |
Total number of gains: 78; Total number of losses: 53; Total Number of normals: 357.
Somatic mutations of LRRC28:
Generating mutation plots.
Highly correlated genes for LRRC28:
Showing top 20/374 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC28 | DDX1 | 0.79235 | 3 | 0 | 3 |
| LRRC28 | PPFIBP2 | 0.791783 | 3 | 0 | 3 |
| LRRC28 | CEPT1 | 0.789165 | 3 | 0 | 3 |
| LRRC28 | SNX17 | 0.781168 | 3 | 0 | 3 |
| LRRC28 | MBOAT2 | 0.778103 | 3 | 0 | 3 |
| LRRC28 | CD2BP2 | 0.773078 | 3 | 0 | 3 |
| LRRC28 | EIF2B4 | 0.766809 | 4 | 0 | 4 |
| LRRC28 | FH | 0.760888 | 3 | 0 | 3 |
| LRRC28 | AP1B1 | 0.760061 | 3 | 0 | 3 |
| LRRC28 | SREBF2 | 0.758806 | 3 | 0 | 3 |
| LRRC28 | NRBP1 | 0.753591 | 3 | 0 | 3 |
| LRRC28 | RAD50 | 0.753007 | 3 | 0 | 3 |
| LRRC28 | TXNDC9 | 0.75141 | 3 | 0 | 3 |
| LRRC28 | GMCL1 | 0.749527 | 3 | 0 | 3 |
| LRRC28 | TMEM186 | 0.74952 | 3 | 0 | 3 |
| LRRC28 | CCNYL1 | 0.74531 | 3 | 0 | 3 |
| LRRC28 | PSMA5 | 0.744009 | 3 | 0 | 3 |
| LRRC28 | RALB | 0.737726 | 3 | 0 | 3 |
| LRRC28 | ABHD14B | 0.737595 | 3 | 0 | 3 |
| LRRC28 | TRIM6 | 0.73484 | 3 | 0 | 3 |
For details and further investigation, click here
