| Full name: mitochondrial ribosomal protein L46 | Alias Symbol: LIECG2|P2ECSL | ||
| Type: protein-coding gene | Cytoband: 15q25.3 | ||
| Entrez ID: 26589 | HGNC ID: HGNC:1192 | Ensembl Gene: ENSG00000259494 | OMIM ID: 611851 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL46 | 26589 | 219244_s_at | -0.3075 | 0.4992 | |
| GSE20347 | MRPL46 | 26589 | 219244_s_at | 0.0609 | 0.7158 | |
| GSE23400 | MRPL46 | 26589 | 219244_s_at | -0.1645 | 0.0014 | |
| GSE26886 | MRPL46 | 26589 | 219244_s_at | -0.5613 | 0.0023 | |
| GSE29001 | MRPL46 | 26589 | 219244_s_at | -0.1438 | 0.6898 | |
| GSE38129 | MRPL46 | 26589 | 219244_s_at | 0.0021 | 0.9888 | |
| GSE45670 | MRPL46 | 26589 | 219244_s_at | -0.1669 | 0.4659 | |
| GSE53622 | MRPL46 | 26589 | 165151 | -0.2202 | 0.0005 | |
| GSE53624 | MRPL46 | 26589 | 165151 | -0.4562 | 0.0000 | |
| GSE63941 | MRPL46 | 26589 | 219244_s_at | 0.5178 | 0.1482 | |
| GSE77861 | MRPL46 | 26589 | 219244_s_at | -0.2506 | 0.3748 | |
| GSE97050 | MRPL46 | 26589 | A_32_P209989 | -0.0060 | 0.9806 | |
| SRP007169 | MRPL46 | 26589 | RNAseq | -0.6696 | 0.1043 | |
| SRP008496 | MRPL46 | 26589 | RNAseq | -1.0881 | 0.0026 | |
| SRP064894 | MRPL46 | 26589 | RNAseq | -0.4641 | 0.0553 | |
| SRP133303 | MRPL46 | 26589 | RNAseq | -0.3907 | 0.0240 | |
| SRP159526 | MRPL46 | 26589 | RNAseq | -0.3857 | 0.0529 | |
| SRP193095 | MRPL46 | 26589 | RNAseq | -0.4742 | 0.0003 | |
| SRP219564 | MRPL46 | 26589 | RNAseq | -0.4320 | 0.2091 | |
| TCGA | MRPL46 | 26589 | RNAseq | -0.0937 | 0.1272 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MRPL46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL46 | 26589 | 7 | 3 | 20 | |
| GSE20123 | MRPL46 | 26589 | 7 | 3 | 20 | |
| GSE43470 | MRPL46 | 26589 | 5 | 4 | 34 | |
| GSE46452 | MRPL46 | 26589 | 3 | 7 | 49 | |
| GSE47630 | MRPL46 | 26589 | 8 | 10 | 22 | |
| GSE54993 | MRPL46 | 26589 | 4 | 6 | 60 | |
| GSE54994 | MRPL46 | 26589 | 7 | 6 | 40 | |
| GSE60625 | MRPL46 | 26589 | 4 | 0 | 7 | |
| GSE74703 | MRPL46 | 26589 | 4 | 3 | 29 | |
| GSE74704 | MRPL46 | 26589 | 4 | 2 | 14 | |
| TCGA | MRPL46 | 26589 | 16 | 12 | 68 |
Total number of gains: 69; Total number of losses: 56; Total Number of normals: 363.
Somatic mutations of MRPL46:
Generating mutation plots.
Highly correlated genes for MRPL46:
Showing top 20/698 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL46 | HERPUD2 | 0.794751 | 3 | 0 | 3 |
| MRPL46 | CCDC126 | 0.771637 | 4 | 0 | 4 |
| MRPL46 | TPM4 | 0.765587 | 3 | 0 | 3 |
| MRPL46 | SARNP | 0.765477 | 3 | 0 | 3 |
| MRPL46 | EXOC2 | 0.759929 | 3 | 0 | 3 |
| MRPL46 | HIPK1 | 0.746392 | 3 | 0 | 3 |
| MRPL46 | DAAM1 | 0.738893 | 3 | 0 | 3 |
| MRPL46 | STAMBP | 0.736699 | 3 | 0 | 3 |
| MRPL46 | ASCC3 | 0.735243 | 4 | 0 | 4 |
| MRPL46 | TRMT11 | 0.733351 | 3 | 0 | 3 |
| MRPL46 | P2RY13 | 0.732204 | 3 | 0 | 3 |
| MRPL46 | CD2BP2 | 0.731684 | 3 | 0 | 3 |
| MRPL46 | WDR20 | 0.731227 | 4 | 0 | 3 |
| MRPL46 | LPCAT2 | 0.729887 | 3 | 0 | 3 |
| MRPL46 | MRPL40 | 0.729736 | 4 | 0 | 4 |
| MRPL46 | MRPS11 | 0.728457 | 11 | 0 | 10 |
| MRPL46 | FRMD6 | 0.725654 | 3 | 0 | 3 |
| MRPL46 | PAIP2 | 0.723534 | 3 | 0 | 3 |
| MRPL46 | FAHD1 | 0.719409 | 4 | 0 | 3 |
| MRPL46 | GCDH | 0.718783 | 3 | 0 | 3 |
For details and further investigation, click here
