| Full name: homer scaffold protein 2 | Alias Symbol: CPD|Cupidin|Vesl-2|HOMER-2B|HOMER-2|HOMER-2A|DFNA68 | ||
| Type: protein-coding gene | Cytoband: 15q25.2 | ||
| Entrez ID: 9455 | HGNC ID: HGNC:17513 | Ensembl Gene: ENSG00000103942 | OMIM ID: 604799 |
| Drug and gene relationship at DGIdb | |||
HOMER2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04724 | Glutamatergic synapse |
Expression of HOMER2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOMER2 | 9455 | 217080_s_at | -0.4626 | 0.6265 | |
| GSE20347 | HOMER2 | 9455 | 217080_s_at | -1.3226 | 0.0000 | |
| GSE23400 | HOMER2 | 9455 | 217080_s_at | -0.6033 | 0.0000 | |
| GSE26886 | HOMER2 | 9455 | 217080_s_at | -0.7791 | 0.0170 | |
| GSE29001 | HOMER2 | 9455 | 217080_s_at | -1.1916 | 0.0001 | |
| GSE38129 | HOMER2 | 9455 | 217080_s_at | -0.7954 | 0.0159 | |
| GSE45670 | HOMER2 | 9455 | 217080_s_at | -0.0075 | 0.9821 | |
| GSE53622 | HOMER2 | 9455 | 112295 | -0.7913 | 0.0001 | |
| GSE53624 | HOMER2 | 9455 | 112295 | -1.3743 | 0.0000 | |
| GSE63941 | HOMER2 | 9455 | 217080_s_at | 2.0101 | 0.0217 | |
| GSE77861 | HOMER2 | 9455 | 217080_s_at | -0.5529 | 0.1323 | |
| GSE97050 | HOMER2 | 9455 | A_23_P99906 | 0.2076 | 0.7686 | |
| SRP007169 | HOMER2 | 9455 | RNAseq | -2.8611 | 0.0000 | |
| SRP064894 | HOMER2 | 9455 | RNAseq | -1.2116 | 0.0002 | |
| SRP133303 | HOMER2 | 9455 | RNAseq | -0.0553 | 0.8672 | |
| SRP159526 | HOMER2 | 9455 | RNAseq | -0.7618 | 0.0153 | |
| SRP193095 | HOMER2 | 9455 | RNAseq | -0.6242 | 0.0019 | |
| SRP219564 | HOMER2 | 9455 | RNAseq | -0.5642 | 0.4574 | |
| TCGA | HOMER2 | 9455 | RNAseq | -0.4770 | 0.0052 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by HOMER2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOMER2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOMER2 | 9455 | 7 | 1 | 22 | |
| GSE20123 | HOMER2 | 9455 | 7 | 1 | 22 | |
| GSE43470 | HOMER2 | 9455 | 4 | 4 | 35 | |
| GSE46452 | HOMER2 | 9455 | 3 | 7 | 49 | |
| GSE47630 | HOMER2 | 9455 | 8 | 10 | 22 | |
| GSE54993 | HOMER2 | 9455 | 5 | 6 | 59 | |
| GSE54994 | HOMER2 | 9455 | 5 | 7 | 41 | |
| GSE60625 | HOMER2 | 9455 | 4 | 0 | 7 | |
| GSE74703 | HOMER2 | 9455 | 4 | 2 | 30 | |
| GSE74704 | HOMER2 | 9455 | 3 | 1 | 16 | |
| TCGA | HOMER2 | 9455 | 15 | 14 | 67 |
Total number of gains: 65; Total number of losses: 53; Total Number of normals: 370.
Somatic mutations of HOMER2:
Generating mutation plots.
Highly correlated genes for HOMER2:
Showing top 20/975 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOMER2 | ORMDL2 | 0.738545 | 8 | 0 | 7 |
| HOMER2 | RABGGTA | 0.725102 | 10 | 0 | 10 |
| HOMER2 | PDCD6IP | 0.702326 | 10 | 0 | 9 |
| HOMER2 | PTGES2 | 0.70134 | 3 | 0 | 3 |
| HOMER2 | TPRKB | 0.700509 | 3 | 0 | 3 |
| HOMER2 | CWH43 | 0.699428 | 10 | 0 | 9 |
| HOMER2 | COMTD1 | 0.697284 | 4 | 0 | 3 |
| HOMER2 | SLC25A39 | 0.695051 | 4 | 0 | 4 |
| HOMER2 | SC5D | 0.692131 | 3 | 0 | 3 |
| HOMER2 | PLD2 | 0.685829 | 11 | 0 | 11 |
| HOMER2 | FAM83G | 0.685748 | 4 | 0 | 3 |
| HOMER2 | CDA | 0.685509 | 13 | 0 | 10 |
| HOMER2 | TOM1 | 0.682393 | 11 | 0 | 9 |
| HOMER2 | METTL15 | 0.682017 | 3 | 0 | 3 |
| HOMER2 | BARX2 | 0.681772 | 8 | 0 | 8 |
| HOMER2 | SH3GL1 | 0.680209 | 10 | 0 | 10 |
| HOMER2 | GRN | 0.675289 | 8 | 0 | 7 |
| HOMER2 | MPV17L | 0.674419 | 4 | 0 | 4 |
| HOMER2 | RGS14 | 0.673692 | 9 | 0 | 9 |
| HOMER2 | TSTD1 | 0.672293 | 5 | 0 | 4 |
For details and further investigation, click here
