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Multi-Omics Database of ESCC

 

HOMER2

 

Full name: homer scaffold protein 2 Alias Symbol: CPD|Cupidin|Vesl-2|HOMER-2B|HOMER-2|HOMER-2A|DFNA68
Type: protein-coding gene Cytoband: 15q25.2
Entrez ID: 9455 HGNC ID: HGNC:17513 Ensembl Gene: ENSG00000103942 OMIM ID: 604799
Drug and gene relationship at DGIdb

 

HOMER2 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04724Glutamatergic synapse

 

Expression of HOMER2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HOMER2 9455 217080_s_at -0.4626 0.6265
GSE20347 HOMER2 9455 217080_s_at -1.3226 0.0000
GSE23400 HOMER2 9455 217080_s_at -0.6033 0.0000
GSE26886 HOMER2 9455 217080_s_at -0.7791 0.0170
GSE29001 HOMER2 9455 217080_s_at -1.1916 0.0001
GSE38129 HOMER2 9455 217080_s_at -0.7954 0.0159
GSE45670 HOMER2 9455 217080_s_at -0.0075 0.9821
GSE53622 HOMER2 9455 112295 -0.7913 0.0001
GSE53624 HOMER2 9455 112295 -1.3743 0.0000
GSE63941 HOMER2 9455 217080_s_at 2.0101 0.0217
GSE77861 HOMER2 9455 217080_s_at -0.5529 0.1323
GSE97050 HOMER2 9455 A_23_P99906 0.2076 0.7686
SRP007169 HOMER2 9455 RNAseq -2.8611 0.0000
SRP064894 HOMER2 9455 RNAseq -1.2116 0.0002
SRP133303 HOMER2 9455 RNAseq -0.0553 0.8672
SRP159526 HOMER2 9455 RNAseq -0.7618 0.0153
SRP193095 HOMER2 9455 RNAseq -0.6242 0.0019
SRP219564 HOMER2 9455 RNAseq -0.5642 0.4574
TCGA HOMER2 9455 RNAseq -0.4770 0.0052

Upregulated datasets: 1; Downregulated datasets: 5.  

 

Survival by HOMER2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HOMER2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HOMER2 9455 7 1 22
GSE20123 HOMER2 9455 7 1 22
GSE43470 HOMER2 9455 4 4 35
GSE46452 HOMER2 9455 3 7 49
GSE47630 HOMER2 9455 8 10 22
GSE54993 HOMER2 9455 5 6 59
GSE54994 HOMER2 9455 5 7 41
GSE60625 HOMER2 9455 4 0 7
GSE74703 HOMER2 9455 4 2 30
GSE74704 HOMER2 9455 3 1 16
TCGA HOMER2 9455 15 14 67

Total number of gains: 65; Total number of losses: 53; Total Number of normals: 370.  

 

Somatic mutations of HOMER2:

 

Generating mutation plots.

 

Highly correlated genes for HOMER2:

 

Showing top 20/975 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HOMER2ORMDL20.738545807
HOMER2RABGGTA0.72510210010
HOMER2PDCD6IP0.7023261009
HOMER2PTGES20.70134303
HOMER2TPRKB0.700509303
HOMER2CWH430.6994281009
HOMER2COMTD10.697284403
HOMER2SLC25A390.695051404
HOMER2SC5D0.692131303
HOMER2PLD20.68582911011
HOMER2FAM83G0.685748403
HOMER2CDA0.68550913010
HOMER2TOM10.6823931109
HOMER2METTL150.682017303
HOMER2BARX20.681772808
HOMER2SH3GL10.68020910010
HOMER2GRN0.675289807
HOMER2MPV17L0.674419404
HOMER2RGS140.673692909
HOMER2TSTD10.672293504

For details and further investigation, click here