| Full name: dentin sialophosphoprotein | Alias Symbol: DMP3 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 1834 | HGNC ID: HGNC:3054 | Ensembl Gene: ENSG00000152591 | OMIM ID: 125485 |
| Drug and gene relationship at DGIdb | |||
Expression of DSPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSPP | 1834 | 221681_s_at | -0.1203 | 0.7154 | |
| GSE20347 | DSPP | 1834 | 221681_s_at | -0.1262 | 0.0940 | |
| GSE23400 | DSPP | 1834 | 221681_s_at | -0.0999 | 0.0000 | |
| GSE26886 | DSPP | 1834 | 221681_s_at | -0.2640 | 0.1592 | |
| GSE29001 | DSPP | 1834 | 221681_s_at | -0.1280 | 0.1720 | |
| GSE38129 | DSPP | 1834 | 221681_s_at | -0.0977 | 0.2608 | |
| GSE45670 | DSPP | 1834 | 221681_s_at | -0.2560 | 0.0935 | |
| GSE53622 | DSPP | 1834 | 55663 | 1.6437 | 0.0000 | |
| GSE53624 | DSPP | 1834 | 55663 | 1.9714 | 0.0000 | |
| GSE63941 | DSPP | 1834 | 221681_s_at | -0.1496 | 0.3512 | |
| GSE77861 | DSPP | 1834 | 221681_s_at | -0.3108 | 0.0889 | |
| GSE97050 | DSPP | 1834 | A_33_P3243028 | 0.1818 | 0.3956 | |
| SRP133303 | DSPP | 1834 | RNAseq | 3.2269 | 0.0005 | |
| TCGA | DSPP | 1834 | RNAseq | 4.7874 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by DSPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSPP | 1834 | 3 | 12 | 15 | |
| GSE20123 | DSPP | 1834 | 3 | 12 | 15 | |
| GSE43470 | DSPP | 1834 | 0 | 13 | 30 | |
| GSE46452 | DSPP | 1834 | 2 | 35 | 22 | |
| GSE47630 | DSPP | 1834 | 0 | 20 | 20 | |
| GSE54993 | DSPP | 1834 | 8 | 0 | 62 | |
| GSE54994 | DSPP | 1834 | 1 | 9 | 43 | |
| GSE60625 | DSPP | 1834 | 0 | 0 | 11 | |
| GSE74703 | DSPP | 1834 | 0 | 11 | 25 | |
| GSE74704 | DSPP | 1834 | 2 | 7 | 11 | |
| TCGA | DSPP | 1834 | 12 | 36 | 48 |
Total number of gains: 31; Total number of losses: 155; Total Number of normals: 302.
Somatic mutations of DSPP:
Generating mutation plots.
Highly correlated genes for DSPP:
Showing top 20/90 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSPP | DHRS7C | 0.80784 | 3 | 0 | 3 |
| DSPP | ANKRD33 | 0.732084 | 3 | 0 | 3 |
| DSPP | SPACA3 | 0.720093 | 3 | 0 | 3 |
| DSPP | TERT | 0.699083 | 4 | 0 | 3 |
| DSPP | CPN1 | 0.698831 | 3 | 0 | 3 |
| DSPP | OR1J4 | 0.697869 | 3 | 0 | 3 |
| DSPP | TNR | 0.691896 | 3 | 0 | 3 |
| DSPP | VCX2 | 0.690891 | 3 | 0 | 3 |
| DSPP | POLR3G | 0.69067 | 3 | 0 | 3 |
| DSPP | KCNMB2 | 0.690258 | 3 | 0 | 3 |
| DSPP | NKPD1 | 0.686703 | 3 | 0 | 3 |
| DSPP | BOLL | 0.67405 | 5 | 0 | 5 |
| DSPP | GNB3 | 0.666938 | 3 | 0 | 3 |
| DSPP | ADAMTS13 | 0.658395 | 4 | 0 | 3 |
| DSPP | SLC6A18 | 0.656895 | 3 | 0 | 3 |
| DSPP | CYP11B1 | 0.655618 | 3 | 0 | 3 |
| DSPP | RFX8 | 0.655382 | 3 | 0 | 3 |
| DSPP | MEP1A | 0.655005 | 4 | 0 | 3 |
| DSPP | SH2D1B | 0.654304 | 4 | 0 | 3 |
| DSPP | DIAPH3-AS1 | 0.639255 | 3 | 0 | 3 |
For details and further investigation, click here
