| Full name: telomerase reverse transcriptase | Alias Symbol: TRT|TP2|TCS1|hEST2|EST2 | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 7015 | HGNC ID: HGNC:11730 | Ensembl Gene: ENSG00000164362 | OMIM ID: 187270 |
| Drug and gene relationship at DGIdb | |||
Expression of TERT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TERT | 7015 | 207199_at | -0.1868 | 0.4497 | |
| GSE20347 | TERT | 7015 | 207199_at | -0.0315 | 0.7771 | |
| GSE23400 | TERT | 7015 | 207199_at | -0.2001 | 0.0000 | |
| GSE26886 | TERT | 7015 | 207199_at | 0.3395 | 0.0045 | |
| GSE29001 | TERT | 7015 | 207199_at | -0.0599 | 0.7303 | |
| GSE38129 | TERT | 7015 | 207199_at | -0.0709 | 0.6137 | |
| GSE45670 | TERT | 7015 | 207199_at | -0.0213 | 0.9037 | |
| GSE53622 | TERT | 7015 | 125404 | -0.2338 | 0.0004 | |
| GSE53624 | TERT | 7015 | 4972 | -0.3553 | 0.0000 | |
| GSE63941 | TERT | 7015 | 207199_at | 0.5811 | 0.0253 | |
| GSE77861 | TERT | 7015 | 207199_at | -0.2422 | 0.1159 | |
| GSE97050 | TERT | 7015 | A_23_P110851 | -0.1375 | 0.5443 | |
| TCGA | TERT | 7015 | RNAseq | 0.8368 | 0.1015 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TERT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TERT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TERT | 7015 | 13 | 1 | 16 | |
| GSE20123 | TERT | 7015 | 13 | 1 | 16 | |
| GSE43470 | TERT | 7015 | 17 | 1 | 25 | |
| GSE46452 | TERT | 7015 | 6 | 22 | 31 | |
| GSE47630 | TERT | 7015 | 7 | 11 | 22 | |
| GSE54993 | TERT | 7015 | 5 | 5 | 60 | |
| GSE54994 | TERT | 7015 | 29 | 1 | 23 | |
| GSE60625 | TERT | 7015 | 0 | 0 | 11 | |
| GSE74703 | TERT | 7015 | 14 | 0 | 22 | |
| GSE74704 | TERT | 7015 | 11 | 0 | 9 | |
| TCGA | TERT | 7015 | 61 | 3 | 32 |
Total number of gains: 176; Total number of losses: 45; Total Number of normals: 267.
Somatic mutations of TERT:
Generating mutation plots.
Highly correlated genes for TERT:
Showing top 20/1159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TERT | TSSK3 | 0.842901 | 3 | 0 | 3 |
| TERT | SCARA5 | 0.824794 | 3 | 0 | 3 |
| TERT | PRSS38 | 0.820842 | 3 | 0 | 3 |
| TERT | OR2B11 | 0.798048 | 3 | 0 | 3 |
| TERT | SP6 | 0.795781 | 4 | 0 | 4 |
| TERT | INSC | 0.786887 | 3 | 0 | 3 |
| TERT | NUDT13 | 0.783909 | 3 | 0 | 3 |
| TERT | MYO15B | 0.78228 | 3 | 0 | 3 |
| TERT | DYTN | 0.781814 | 3 | 0 | 3 |
| TERT | SLC22A12 | 0.781209 | 3 | 0 | 3 |
| TERT | TMEM179 | 0.776534 | 3 | 0 | 3 |
| TERT | MYLK2 | 0.770469 | 3 | 0 | 3 |
| TERT | YY2 | 0.768077 | 3 | 0 | 3 |
| TERT | GDF7 | 0.767857 | 3 | 0 | 3 |
| TERT | ACSBG2 | 0.765334 | 3 | 0 | 3 |
| TERT | OTOG | 0.760652 | 3 | 0 | 3 |
| TERT | SPTBN5 | 0.755897 | 4 | 0 | 4 |
| TERT | ENTPD8 | 0.753218 | 3 | 0 | 3 |
| TERT | RGL4 | 0.752657 | 3 | 0 | 3 |
| TERT | SPN | 0.746766 | 3 | 0 | 3 |
For details and further investigation, click here
