| Full name: SH2 domain containing 1B | Alias Symbol: EAT2 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 117157 | HGNC ID: HGNC:30416 | Ensembl Gene: ENSG00000198574 | OMIM ID: 608510 |
| Drug and gene relationship at DGIdb | |||
SH2D1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of SH2D1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2D1B | 117157 | 1553177_at | -0.3930 | 0.3154 | |
| GSE26886 | SH2D1B | 117157 | 1553177_at | -1.9208 | 0.0002 | |
| GSE45670 | SH2D1B | 117157 | 1553177_at | -0.0409 | 0.9228 | |
| GSE53622 | SH2D1B | 117157 | 25569 | -0.0742 | 0.3974 | |
| GSE53624 | SH2D1B | 117157 | 25569 | -0.4323 | 0.0000 | |
| GSE63941 | SH2D1B | 117157 | 1553177_at | -0.1335 | 0.4234 | |
| GSE77861 | SH2D1B | 117157 | 1553177_at | -0.1825 | 0.0432 | |
| GSE97050 | SH2D1B | 117157 | A_23_P351148 | -0.0465 | 0.9100 | |
| SRP133303 | SH2D1B | 117157 | RNAseq | -1.2028 | 0.0108 | |
| SRP159526 | SH2D1B | 117157 | RNAseq | -1.9482 | 0.0190 | |
| TCGA | SH2D1B | 117157 | RNAseq | -0.5148 | 0.2438 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SH2D1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH2D1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2D1B | 117157 | 10 | 0 | 20 | |
| GSE20123 | SH2D1B | 117157 | 10 | 0 | 20 | |
| GSE43470 | SH2D1B | 117157 | 7 | 2 | 34 | |
| GSE46452 | SH2D1B | 117157 | 2 | 1 | 56 | |
| GSE47630 | SH2D1B | 117157 | 14 | 0 | 26 | |
| GSE54993 | SH2D1B | 117157 | 0 | 5 | 65 | |
| GSE54994 | SH2D1B | 117157 | 16 | 0 | 37 | |
| GSE60625 | SH2D1B | 117157 | 0 | 0 | 11 | |
| GSE74703 | SH2D1B | 117157 | 7 | 2 | 27 | |
| GSE74704 | SH2D1B | 117157 | 4 | 0 | 16 | |
| TCGA | SH2D1B | 117157 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of SH2D1B:
Generating mutation plots.
Highly correlated genes for SH2D1B:
Showing top 20/296 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2D1B | ANKRD33 | 0.813403 | 3 | 0 | 3 |
| SH2D1B | IL22RA2 | 0.774822 | 3 | 0 | 3 |
| SH2D1B | CD300LG | 0.768793 | 4 | 0 | 4 |
| SH2D1B | FGF22 | 0.767175 | 3 | 0 | 3 |
| SH2D1B | SHOC2 | 0.763619 | 3 | 0 | 3 |
| SH2D1B | CATSPER3 | 0.760228 | 3 | 0 | 3 |
| SH2D1B | MAP3K9 | 0.758352 | 3 | 0 | 3 |
| SH2D1B | MFSD1 | 0.752593 | 4 | 0 | 3 |
| SH2D1B | CCDC157 | 0.751488 | 3 | 0 | 3 |
| SH2D1B | ATP10B | 0.750855 | 3 | 0 | 3 |
| SH2D1B | GPT2 | 0.749339 | 3 | 0 | 3 |
| SH2D1B | SLC6A18 | 0.747335 | 3 | 0 | 3 |
| SH2D1B | RHBG | 0.744432 | 3 | 0 | 3 |
| SH2D1B | ABCD3 | 0.744428 | 4 | 0 | 3 |
| SH2D1B | SPNS2 | 0.744426 | 3 | 0 | 3 |
| SH2D1B | RPIA | 0.742703 | 3 | 0 | 3 |
| SH2D1B | ERMP1 | 0.741222 | 4 | 0 | 3 |
| SH2D1B | GGT6 | 0.739952 | 5 | 0 | 4 |
| SH2D1B | TNR | 0.735785 | 3 | 0 | 3 |
| SH2D1B | CABP7 | 0.727905 | 3 | 0 | 3 |
For details and further investigation, click here
