GNB3

 

Full name: G protein subunit beta 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 2784 HGNC ID: HGNC:4400 Ensembl Gene: ENSG00000111664 OMIM ID: 139130
Drug and gene relationship at DGIdb

 

GNB3 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04742Taste transduction
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNB3 2784 206047_at -0.0639 0.7650
GSE20347 GNB3 2784 206047_at 0.1075 0.1512
GSE23400 GNB3 2784 206047_at -0.1080 0.0009
GSE26886 GNB3 2784 206047_at 0.0016 0.9901
GSE29001 GNB3 2784 206047_at -0.0328 0.8691
GSE38129 GNB3 2784 206047_at -0.0181 0.8474
GSE45670 GNB3 2784 206047_at 0.0499 0.5750
GSE53622 GNB3 2784 16031 0.5475 0.0000
GSE53624 GNB3 2784 16031 0.6157 0.0000
GSE63941 GNB3 2784 206047_at -0.0108 0.9442
GSE77861 GNB3 2784 206047_at -0.0560 0.6925
GSE97050 GNB3 2784 A_23_P76350 0.2725 0.2354
SRP064894 GNB3 2784 RNAseq 1.0453 0.0001
SRP133303 GNB3 2784 RNAseq 0.5264 0.0966
SRP159526 GNB3 2784 RNAseq 1.5596 0.0050
SRP219564 GNB3 2784 RNAseq 0.6041 0.1221
TCGA GNB3 2784 RNAseq -0.2837 0.2934

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by GNB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNB3 2784 9 3 18
GSE20123 GNB3 2784 9 3 18
GSE43470 GNB3 2784 8 3 32
GSE46452 GNB3 2784 10 1 48
GSE47630 GNB3 2784 12 2 26
GSE54993 GNB3 2784 1 10 59
GSE54994 GNB3 2784 10 2 41
GSE60625 GNB3 2784 0 1 10
GSE74703 GNB3 2784 7 2 27
GSE74704 GNB3 2784 5 3 12
TCGA GNB3 2784 40 6 50

Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.  

 

Somatic mutations of GNB3:

 

Generating mutation plots.

 

Highly correlated genes for GNB3:

 

Showing top 20/970 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNB3MEGF110.828541303
GNB3C2CD4D0.802664303
GNB3DCDC10.787647303
GNB3FBRSL10.784149303
GNB3SUN50.776586303
GNB3LRRC100.767617303
GNB3STRC0.765455303
GNB3PTK2B0.760633303
GNB3D2HGDH0.7577303
GNB3LHB0.753081303
GNB3NTNG20.750961404
GNB3C1QL20.749557303
GNB3MAPK150.749516404
GNB3MS4A180.749045303
GNB3PSMB110.743693303
GNB3STX1B0.740681404
GNB3MRGPRG0.735463303
GNB3HAGHL0.731739404
GNB3C19orf440.728016404
GNB3CEACAM200.725178303

For details and further investigation, click here