| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 13 | Alias Symbol: VWFCP|TTP|vWF-CP|FLJ42993|MGC118899|MGC118900|DKFZp434C2322 | ||
| Type: protein-coding gene | Cytoband: 9q34.2 | ||
| Entrez ID: 11093 | HGNC ID: HGNC:1366 | Ensembl Gene: ENSG00000160323 | OMIM ID: 604134 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS13 | 11093 | 220208_at | 0.1459 | 0.4536 | |
| GSE20347 | ADAMTS13 | 11093 | 220208_at | 0.0170 | 0.8533 | |
| GSE23400 | ADAMTS13 | 11093 | 220208_at | -0.1498 | 0.0006 | |
| GSE26886 | ADAMTS13 | 11093 | 220208_at | 0.0554 | 0.6605 | |
| GSE29001 | ADAMTS13 | 11093 | 220208_at | -0.0390 | 0.8203 | |
| GSE38129 | ADAMTS13 | 11093 | 220208_at | -0.0272 | 0.7211 | |
| GSE45670 | ADAMTS13 | 11093 | 220208_at | 0.0781 | 0.2866 | |
| GSE53622 | ADAMTS13 | 11093 | 136597 | 0.1940 | 0.0234 | |
| GSE53624 | ADAMTS13 | 11093 | 136597 | 0.1131 | 0.2304 | |
| GSE63941 | ADAMTS13 | 11093 | 220208_at | -0.0775 | 0.5832 | |
| GSE77861 | ADAMTS13 | 11093 | 220208_at | -0.1926 | 0.0868 | |
| GSE97050 | ADAMTS13 | 11093 | A_23_P393645 | -0.0727 | 0.7585 | |
| SRP064894 | ADAMTS13 | 11093 | RNAseq | 1.0977 | 0.0013 | |
| SRP133303 | ADAMTS13 | 11093 | RNAseq | 0.2928 | 0.5407 | |
| SRP159526 | ADAMTS13 | 11093 | RNAseq | 1.4907 | 0.0483 | |
| SRP193095 | ADAMTS13 | 11093 | RNAseq | 0.1512 | 0.6305 | |
| SRP219564 | ADAMTS13 | 11093 | RNAseq | 0.8850 | 0.2084 | |
| TCGA | ADAMTS13 | 11093 | RNAseq | -0.6893 | 0.0017 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ADAMTS13 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS13 | 11093 | 5 | 7 | 18 | |
| GSE20123 | ADAMTS13 | 11093 | 5 | 7 | 18 | |
| GSE43470 | ADAMTS13 | 11093 | 4 | 7 | 32 | |
| GSE46452 | ADAMTS13 | 11093 | 6 | 13 | 40 | |
| GSE47630 | ADAMTS13 | 11093 | 4 | 15 | 21 | |
| GSE54993 | ADAMTS13 | 11093 | 3 | 3 | 64 | |
| GSE54994 | ADAMTS13 | 11093 | 12 | 9 | 32 | |
| GSE60625 | ADAMTS13 | 11093 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS13 | 11093 | 4 | 5 | 27 | |
| GSE74704 | ADAMTS13 | 11093 | 3 | 5 | 12 | |
| TCGA | ADAMTS13 | 11093 | 28 | 26 | 42 |
Total number of gains: 74; Total number of losses: 97; Total Number of normals: 317.
Somatic mutations of ADAMTS13:
Generating mutation plots.
Highly correlated genes for ADAMTS13:
Showing top 20/722 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS13 | FBXO15 | 0.835878 | 3 | 0 | 3 |
| ADAMTS13 | BCL6B | 0.831779 | 3 | 0 | 3 |
| ADAMTS13 | HDAC8 | 0.796123 | 3 | 0 | 3 |
| ADAMTS13 | CD300LG | 0.795229 | 3 | 0 | 3 |
| ADAMTS13 | FAM171A2 | 0.777144 | 3 | 0 | 3 |
| ADAMTS13 | DRG2 | 0.760636 | 3 | 0 | 3 |
| ADAMTS13 | SP6 | 0.755395 | 3 | 0 | 3 |
| ADAMTS13 | SCARF2 | 0.742655 | 3 | 0 | 3 |
| ADAMTS13 | CACNG8 | 0.741769 | 3 | 0 | 3 |
| ADAMTS13 | GPSM3 | 0.733708 | 3 | 0 | 3 |
| ADAMTS13 | DIO3 | 0.733674 | 4 | 0 | 3 |
| ADAMTS13 | BTBD8 | 0.726291 | 3 | 0 | 3 |
| ADAMTS13 | ALPL | 0.724162 | 3 | 0 | 3 |
| ADAMTS13 | TNXB | 0.721432 | 6 | 0 | 5 |
| ADAMTS13 | BCL2L10 | 0.721032 | 4 | 0 | 4 |
| ADAMTS13 | CRYGC | 0.718985 | 5 | 0 | 5 |
| ADAMTS13 | PRAMEF12 | 0.71832 | 5 | 0 | 5 |
| ADAMTS13 | ICAM3 | 0.71525 | 3 | 0 | 3 |
| ADAMTS13 | RNF17 | 0.71455 | 5 | 0 | 5 |
| ADAMTS13 | PHF7 | 0.71335 | 7 | 0 | 6 |
For details and further investigation, click here
