| Full name: destrin, actin depolymerizing factor | Alias Symbol: ADF|ACTDP | ||
| Type: protein-coding gene | Cytoband: 20p12.1 | ||
| Entrez ID: 11034 | HGNC ID: HGNC:15750 | Ensembl Gene: ENSG00000125868 | OMIM ID: 609114 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DSTN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSTN | 11034 | 201022_s_at | -0.5691 | 0.2155 | |
| GSE20347 | DSTN | 11034 | 201022_s_at | -0.6305 | 0.0005 | |
| GSE23400 | DSTN | 11034 | 201022_s_at | -0.5056 | 0.0000 | |
| GSE26886 | DSTN | 11034 | 201022_s_at | -0.3453 | 0.0297 | |
| GSE29001 | DSTN | 11034 | 201022_s_at | -0.7052 | 0.0978 | |
| GSE38129 | DSTN | 11034 | 201022_s_at | -0.7049 | 0.0002 | |
| GSE45670 | DSTN | 11034 | 201022_s_at | -0.5654 | 0.0000 | |
| GSE53622 | DSTN | 11034 | 86650 | -1.1913 | 0.0000 | |
| GSE53624 | DSTN | 11034 | 86650 | -0.8027 | 0.0000 | |
| GSE63941 | DSTN | 11034 | 201022_s_at | -1.0248 | 0.0184 | |
| GSE77861 | DSTN | 11034 | 201022_s_at | -0.1127 | 0.4736 | |
| GSE97050 | DSTN | 11034 | A_23_P408095 | -1.3721 | 0.1194 | |
| SRP007169 | DSTN | 11034 | RNAseq | -0.1553 | 0.6834 | |
| SRP008496 | DSTN | 11034 | RNAseq | 0.1690 | 0.5779 | |
| SRP064894 | DSTN | 11034 | RNAseq | -0.8320 | 0.0001 | |
| SRP133303 | DSTN | 11034 | RNAseq | -0.2864 | 0.3542 | |
| SRP159526 | DSTN | 11034 | RNAseq | -0.9781 | 0.0032 | |
| SRP193095 | DSTN | 11034 | RNAseq | -0.7680 | 0.0000 | |
| SRP219564 | DSTN | 11034 | RNAseq | -1.0663 | 0.1849 | |
| TCGA | DSTN | 11034 | RNAseq | -0.2021 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DSTN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSTN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSTN | 11034 | 12 | 3 | 15 | |
| GSE20123 | DSTN | 11034 | 12 | 3 | 15 | |
| GSE43470 | DSTN | 11034 | 11 | 1 | 31 | |
| GSE46452 | DSTN | 11034 | 27 | 1 | 31 | |
| GSE47630 | DSTN | 11034 | 17 | 4 | 19 | |
| GSE54993 | DSTN | 11034 | 0 | 15 | 55 | |
| GSE54994 | DSTN | 11034 | 26 | 2 | 25 | |
| GSE60625 | DSTN | 11034 | 0 | 0 | 11 | |
| GSE74703 | DSTN | 11034 | 8 | 1 | 27 | |
| GSE74704 | DSTN | 11034 | 7 | 2 | 11 | |
| TCGA | DSTN | 11034 | 43 | 10 | 43 |
Total number of gains: 163; Total number of losses: 42; Total Number of normals: 283.
Somatic mutations of DSTN:
Generating mutation plots.
Highly correlated genes for DSTN:
Showing top 20/1218 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSTN | KCNB1 | 0.789195 | 4 | 0 | 4 |
| DSTN | RASSF3 | 0.78307 | 5 | 0 | 5 |
| DSTN | DNAJC15 | 0.761568 | 3 | 0 | 3 |
| DSTN | PARVA | 0.754244 | 9 | 0 | 8 |
| DSTN | AFF3 | 0.752747 | 3 | 0 | 3 |
| DSTN | ILK | 0.734 | 8 | 0 | 8 |
| DSTN | XKR4 | 0.733951 | 5 | 0 | 4 |
| DSTN | OGN | 0.731908 | 7 | 0 | 7 |
| DSTN | MYOCD | 0.730369 | 6 | 0 | 6 |
| DSTN | FXYD1 | 0.728695 | 6 | 0 | 6 |
| DSTN | OSBPL1A | 0.727805 | 8 | 0 | 8 |
| DSTN | CLMP | 0.727137 | 3 | 0 | 3 |
| DSTN | SLMAP | 0.725473 | 7 | 0 | 6 |
| DSTN | MGARP | 0.724521 | 3 | 0 | 3 |
| DSTN | SMTN | 0.724055 | 7 | 0 | 5 |
| DSTN | PPARGC1A | 0.719971 | 7 | 0 | 7 |
| DSTN | FRRS1L | 0.71971 | 4 | 0 | 4 |
| DSTN | MAGI2-AS3 | 0.718381 | 4 | 0 | 4 |
| DSTN | C1QTNF7 | 0.716112 | 5 | 0 | 4 |
| DSTN | COX7A1 | 0.715836 | 9 | 0 | 8 |
For details and further investigation, click here
