| Full name: smoothelin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 6525 | HGNC ID: HGNC:11126 | Ensembl Gene: ENSG00000183963 | OMIM ID: 602127 |
| Drug and gene relationship at DGIdb | |||
Expression of SMTN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMTN | 6525 | 207390_s_at | -1.3012 | 0.3679 | |
| GSE20347 | SMTN | 6525 | 209427_at | 0.3603 | 0.1796 | |
| GSE23400 | SMTN | 6525 | 207390_s_at | -1.0546 | 0.0000 | |
| GSE26886 | SMTN | 6525 | 207390_s_at | 1.1108 | 0.0010 | |
| GSE29001 | SMTN | 6525 | 209427_at | -0.1738 | 0.3407 | |
| GSE38129 | SMTN | 6525 | 207390_s_at | -1.0107 | 0.0644 | |
| GSE45670 | SMTN | 6525 | 209427_at | -0.5545 | 0.0456 | |
| GSE53622 | SMTN | 6525 | 133626 | -1.3357 | 0.0000 | |
| GSE53624 | SMTN | 6525 | 133626 | -1.0598 | 0.0000 | |
| GSE63941 | SMTN | 6525 | 209427_at | 0.1604 | 0.7906 | |
| GSE77861 | SMTN | 6525 | 209427_at | 1.0002 | 0.0053 | |
| GSE97050 | SMTN | 6525 | A_23_P211428 | -1.4960 | 0.1221 | |
| SRP007169 | SMTN | 6525 | RNAseq | 1.8553 | 0.0025 | |
| SRP008496 | SMTN | 6525 | RNAseq | 1.7721 | 0.0003 | |
| SRP064894 | SMTN | 6525 | RNAseq | -0.7779 | 0.0031 | |
| SRP133303 | SMTN | 6525 | RNAseq | -0.3124 | 0.5701 | |
| SRP159526 | SMTN | 6525 | RNAseq | -1.3016 | 0.0107 | |
| SRP193095 | SMTN | 6525 | RNAseq | 1.2448 | 0.0000 | |
| SRP219564 | SMTN | 6525 | RNAseq | -1.4914 | 0.1621 | |
| TCGA | SMTN | 6525 | RNAseq | -0.3146 | 0.0002 |
Upregulated datasets: 5; Downregulated datasets: 4.
Survival by SMTN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMTN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMTN | 6525 | 4 | 5 | 21 | |
| GSE20123 | SMTN | 6525 | 4 | 4 | 22 | |
| GSE43470 | SMTN | 6525 | 4 | 5 | 34 | |
| GSE46452 | SMTN | 6525 | 31 | 1 | 27 | |
| GSE47630 | SMTN | 6525 | 8 | 5 | 27 | |
| GSE54993 | SMTN | 6525 | 3 | 6 | 61 | |
| GSE54994 | SMTN | 6525 | 12 | 7 | 34 | |
| GSE60625 | SMTN | 6525 | 5 | 0 | 6 | |
| GSE74703 | SMTN | 6525 | 4 | 5 | 27 | |
| GSE74704 | SMTN | 6525 | 1 | 1 | 18 | |
| TCGA | SMTN | 6525 | 27 | 15 | 54 |
Total number of gains: 103; Total number of losses: 54; Total Number of normals: 331.
Somatic mutations of SMTN:
Generating mutation plots.
Highly correlated genes for SMTN:
Showing top 20/958 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMTN | FGF12 | 0.822316 | 3 | 0 | 3 |
| SMTN | ACTBL2 | 0.807159 | 3 | 0 | 3 |
| SMTN | FXYD1 | 0.801964 | 5 | 0 | 5 |
| SMTN | FLNA | 0.79724 | 11 | 0 | 11 |
| SMTN | TPM1 | 0.792509 | 10 | 0 | 10 |
| SMTN | JAM2 | 0.792251 | 6 | 0 | 6 |
| SMTN | CBX7 | 0.789025 | 6 | 0 | 6 |
| SMTN | INMT | 0.788726 | 5 | 0 | 5 |
| SMTN | PRICKLE1 | 0.787217 | 3 | 0 | 3 |
| SMTN | SH3BGR | 0.785622 | 7 | 0 | 6 |
| SMTN | PPP1R14A | 0.781551 | 6 | 0 | 6 |
| SMTN | ITPR1 | 0.781118 | 6 | 0 | 6 |
| SMTN | ASB5 | 0.780595 | 5 | 0 | 5 |
| SMTN | DCHS1 | 0.780126 | 5 | 0 | 5 |
| SMTN | TPM2 | 0.778949 | 10 | 0 | 9 |
| SMTN | TGFB1I1 | 0.778922 | 11 | 0 | 11 |
| SMTN | FLNC | 0.775106 | 10 | 0 | 9 |
| SMTN | CYP21A2 | 0.771609 | 3 | 0 | 3 |
| SMTN | GMPR | 0.770572 | 3 | 0 | 3 |
| SMTN | LIMS2 | 0.769765 | 9 | 0 | 8 |
For details and further investigation, click here
