| Full name: PPARG coactivator 1 alpha | Alias Symbol: PGC1|PGC1A|PGC-1alpha | ||
| Type: protein-coding gene | Cytoband: 4p15.2 | ||
| Entrez ID: 10891 | HGNC ID: HGNC:9237 | Ensembl Gene: ENSG00000109819 | OMIM ID: 604517 |
| Drug and gene relationship at DGIdb | |||
PPARGC1A involved pathways:
Expression of PPARGC1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPARGC1A | 10891 | 219195_at | -1.6534 | 0.1516 | |
| GSE20347 | PPARGC1A | 10891 | 219195_at | -0.1953 | 0.4844 | |
| GSE23400 | PPARGC1A | 10891 | 219195_at | -0.2939 | 0.0003 | |
| GSE26886 | PPARGC1A | 10891 | 219195_at | 0.5492 | 0.2597 | |
| GSE29001 | PPARGC1A | 10891 | 219195_at | -0.3290 | 0.4700 | |
| GSE38129 | PPARGC1A | 10891 | 219195_at | -0.7779 | 0.0135 | |
| GSE45670 | PPARGC1A | 10891 | 219195_at | -1.7340 | 0.0000 | |
| GSE53622 | PPARGC1A | 10891 | 89729 | -1.6251 | 0.0000 | |
| GSE53624 | PPARGC1A | 10891 | 91299 | -1.1382 | 0.0000 | |
| GSE63941 | PPARGC1A | 10891 | 219195_at | -1.7388 | 0.0410 | |
| GSE77861 | PPARGC1A | 10891 | 1569141_a_at | -0.0445 | 0.6221 | |
| GSE97050 | PPARGC1A | 10891 | A_23_P18447 | -1.6107 | 0.1082 | |
| SRP007169 | PPARGC1A | 10891 | RNAseq | 0.1326 | 0.8693 | |
| SRP064894 | PPARGC1A | 10891 | RNAseq | -0.4101 | 0.3260 | |
| SRP133303 | PPARGC1A | 10891 | RNAseq | -0.2892 | 0.5889 | |
| SRP159526 | PPARGC1A | 10891 | RNAseq | 0.3244 | 0.5240 | |
| SRP193095 | PPARGC1A | 10891 | RNAseq | 0.4719 | 0.1797 | |
| SRP219564 | PPARGC1A | 10891 | RNAseq | 0.6415 | 0.5607 | |
| TCGA | PPARGC1A | 10891 | RNAseq | -1.0726 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PPARGC1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPARGC1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPARGC1A | 10891 | 0 | 18 | 12 | |
| GSE20123 | PPARGC1A | 10891 | 0 | 17 | 13 | |
| GSE43470 | PPARGC1A | 10891 | 0 | 15 | 28 | |
| GSE46452 | PPARGC1A | 10891 | 1 | 36 | 22 | |
| GSE47630 | PPARGC1A | 10891 | 1 | 19 | 20 | |
| GSE54993 | PPARGC1A | 10891 | 9 | 0 | 61 | |
| GSE54994 | PPARGC1A | 10891 | 4 | 11 | 38 | |
| GSE60625 | PPARGC1A | 10891 | 0 | 0 | 11 | |
| GSE74703 | PPARGC1A | 10891 | 0 | 13 | 23 | |
| GSE74704 | PPARGC1A | 10891 | 0 | 11 | 9 | |
| TCGA | PPARGC1A | 10891 | 12 | 47 | 37 |
Total number of gains: 27; Total number of losses: 187; Total Number of normals: 274.
Somatic mutations of PPARGC1A:
Generating mutation plots.
Highly correlated genes for PPARGC1A:
Showing top 20/959 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPARGC1A | RAB9B | 0.812259 | 5 | 0 | 5 |
| PPARGC1A | MSRB3 | 0.798206 | 4 | 0 | 4 |
| PPARGC1A | CAMK2G | 0.79709 | 5 | 0 | 5 |
| PPARGC1A | FAM13C | 0.786633 | 4 | 0 | 4 |
| PPARGC1A | RBM24 | 0.767427 | 4 | 0 | 4 |
| PPARGC1A | SPOP | 0.763494 | 6 | 0 | 6 |
| PPARGC1A | MYOCD | 0.759951 | 6 | 0 | 5 |
| PPARGC1A | DUSP3 | 0.756479 | 6 | 0 | 6 |
| PPARGC1A | LIMS2 | 0.756153 | 8 | 0 | 7 |
| PPARGC1A | FILIP1 | 0.754632 | 5 | 0 | 5 |
| PPARGC1A | SORCS1 | 0.752999 | 4 | 0 | 4 |
| PPARGC1A | MAMDC2 | 0.750844 | 5 | 0 | 5 |
| PPARGC1A | RASSF3 | 0.750625 | 4 | 0 | 4 |
| PPARGC1A | MYL6 | 0.749846 | 5 | 0 | 5 |
| PPARGC1A | SGCA | 0.743583 | 8 | 0 | 7 |
| PPARGC1A | C1QTNF7 | 0.743401 | 5 | 0 | 4 |
| PPARGC1A | FBXL3 | 0.737813 | 3 | 0 | 3 |
| PPARGC1A | BTD | 0.737756 | 3 | 0 | 3 |
| PPARGC1A | MECP2 | 0.737283 | 4 | 0 | 4 |
| PPARGC1A | PARD3B | 0.735609 | 5 | 0 | 4 |
For details and further investigation, click here
