| Full name: oxysterol binding protein like 1A | Alias Symbol: ORP-1|ORP1 | ||
| Type: protein-coding gene | Cytoband: 18q11.2 | ||
| Entrez ID: 114876 | HGNC ID: HGNC:16398 | Ensembl Gene: ENSG00000141447 | OMIM ID: 606730 |
| Drug and gene relationship at DGIdb | |||
Expression of OSBPL1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSBPL1A | 114876 | 208158_s_at | -1.2428 | 0.0523 | |
| GSE20347 | OSBPL1A | 114876 | 208158_s_at | -0.6524 | 0.0122 | |
| GSE23400 | OSBPL1A | 114876 | 208158_s_at | -0.2643 | 0.0032 | |
| GSE26886 | OSBPL1A | 114876 | 208158_s_at | -0.1163 | 0.6862 | |
| GSE29001 | OSBPL1A | 114876 | 208158_s_at | -0.6085 | 0.1088 | |
| GSE38129 | OSBPL1A | 114876 | 208158_s_at | -0.7948 | 0.0009 | |
| GSE45670 | OSBPL1A | 114876 | 208158_s_at | -1.1006 | 0.0000 | |
| GSE53622 | OSBPL1A | 114876 | 51359 | -0.7956 | 0.0000 | |
| GSE53624 | OSBPL1A | 114876 | 51359 | -0.4922 | 0.0000 | |
| GSE63941 | OSBPL1A | 114876 | 208158_s_at | -0.9827 | 0.1082 | |
| GSE77861 | OSBPL1A | 114876 | 208158_s_at | -0.1007 | 0.7722 | |
| GSE97050 | OSBPL1A | 114876 | A_33_P3308534 | 0.1417 | 0.7344 | |
| SRP007169 | OSBPL1A | 114876 | RNAseq | -1.1666 | 0.0380 | |
| SRP008496 | OSBPL1A | 114876 | RNAseq | -0.9142 | 0.0126 | |
| SRP064894 | OSBPL1A | 114876 | RNAseq | -0.9086 | 0.0001 | |
| SRP133303 | OSBPL1A | 114876 | RNAseq | -0.4957 | 0.0272 | |
| SRP159526 | OSBPL1A | 114876 | RNAseq | -0.4147 | 0.0780 | |
| SRP193095 | OSBPL1A | 114876 | RNAseq | -0.4967 | 0.0011 | |
| SRP219564 | OSBPL1A | 114876 | RNAseq | -0.5514 | 0.2915 | |
| TCGA | OSBPL1A | 114876 | RNAseq | -0.1994 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by OSBPL1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSBPL1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSBPL1A | 114876 | 4 | 5 | 21 | |
| GSE20123 | OSBPL1A | 114876 | 3 | 5 | 22 | |
| GSE43470 | OSBPL1A | 114876 | 2 | 1 | 40 | |
| GSE46452 | OSBPL1A | 114876 | 3 | 24 | 32 | |
| GSE47630 | OSBPL1A | 114876 | 7 | 18 | 15 | |
| GSE54993 | OSBPL1A | 114876 | 7 | 1 | 62 | |
| GSE54994 | OSBPL1A | 114876 | 2 | 14 | 37 | |
| GSE60625 | OSBPL1A | 114876 | 0 | 4 | 7 | |
| GSE74703 | OSBPL1A | 114876 | 2 | 1 | 33 | |
| GSE74704 | OSBPL1A | 114876 | 2 | 4 | 14 | |
| TCGA | OSBPL1A | 114876 | 16 | 30 | 50 |
Total number of gains: 48; Total number of losses: 107; Total Number of normals: 333.
Somatic mutations of OSBPL1A:
Generating mutation plots.
Highly correlated genes for OSBPL1A:
Showing top 20/574 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSBPL1A | FBXL3 | 0.750232 | 3 | 0 | 3 |
| OSBPL1A | RAB9B | 0.731327 | 4 | 0 | 4 |
| OSBPL1A | RASL12 | 0.731317 | 5 | 0 | 5 |
| OSBPL1A | DSTN | 0.727805 | 8 | 0 | 8 |
| OSBPL1A | MAMDC2 | 0.722182 | 5 | 0 | 4 |
| OSBPL1A | DAAM2 | 0.721025 | 5 | 0 | 4 |
| OSBPL1A | MYOCD | 0.710011 | 4 | 0 | 3 |
| OSBPL1A | GNPDA2 | 0.705 | 6 | 0 | 6 |
| OSBPL1A | XKR4 | 0.702224 | 4 | 0 | 4 |
| OSBPL1A | CASQ2 | 0.700262 | 7 | 0 | 6 |
| OSBPL1A | STARD9 | 0.693862 | 4 | 0 | 4 |
| OSBPL1A | CCDC69 | 0.692143 | 6 | 0 | 5 |
| OSBPL1A | KCNT2 | 0.688868 | 4 | 0 | 4 |
| OSBPL1A | PYGM | 0.682105 | 6 | 0 | 5 |
| OSBPL1A | PLP1 | 0.679093 | 7 | 0 | 6 |
| OSBPL1A | ILK | 0.678464 | 8 | 0 | 8 |
| OSBPL1A | CREBRF | 0.67845 | 4 | 0 | 4 |
| OSBPL1A | SH3BGRL | 0.677168 | 8 | 0 | 8 |
| OSBPL1A | MRVI1 | 0.670016 | 6 | 0 | 5 |
| OSBPL1A | ZBTB16 | 0.665744 | 6 | 0 | 5 |
For details and further investigation, click here
