| Full name: potassium voltage-gated channel subfamily B member 1 | Alias Symbol: Kv2.1 | ||
| Type: protein-coding gene | Cytoband: 20q13.13 | ||
| Entrez ID: 3745 | HGNC ID: HGNC:6231 | Ensembl Gene: ENSG00000158445 | OMIM ID: 600397 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNB1 | 3745 | 211006_s_at | -2.0204 | 0.1750 | |
| GSE20347 | KCNB1 | 3745 | 217637_at | 0.1056 | 0.2828 | |
| GSE23400 | KCNB1 | 3745 | 217637_at | -0.1397 | 0.0002 | |
| GSE26886 | KCNB1 | 3745 | 217637_at | 0.0008 | 0.9948 | |
| GSE29001 | KCNB1 | 3745 | 211006_s_at | -0.4692 | 0.0673 | |
| GSE38129 | KCNB1 | 3745 | 217637_at | -0.0307 | 0.7602 | |
| GSE45670 | KCNB1 | 3745 | 217637_at | 0.1689 | 0.0906 | |
| GSE53622 | KCNB1 | 3745 | 43182 | -3.7978 | 0.0000 | |
| GSE53624 | KCNB1 | 3745 | 43182 | -3.8123 | 0.0000 | |
| GSE63941 | KCNB1 | 3745 | 217637_at | 0.1640 | 0.2515 | |
| GSE77861 | KCNB1 | 3745 | 217637_at | -0.0652 | 0.4453 | |
| GSE97050 | KCNB1 | 3745 | A_24_P31627 | -1.5454 | 0.1143 | |
| SRP064894 | KCNB1 | 3745 | RNAseq | -0.7433 | 0.1869 | |
| SRP133303 | KCNB1 | 3745 | RNAseq | -1.4069 | 0.0218 | |
| SRP159526 | KCNB1 | 3745 | RNAseq | -2.3599 | 0.0000 | |
| SRP193095 | KCNB1 | 3745 | RNAseq | -0.4754 | 0.0270 | |
| SRP219564 | KCNB1 | 3745 | RNAseq | -0.7880 | 0.4231 | |
| TCGA | KCNB1 | 3745 | RNAseq | -2.1079 | 0.0027 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by KCNB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNB1 | 3745 | 16 | 2 | 12 | |
| GSE20123 | KCNB1 | 3745 | 16 | 2 | 12 | |
| GSE43470 | KCNB1 | 3745 | 13 | 0 | 30 | |
| GSE46452 | KCNB1 | 3745 | 29 | 0 | 30 | |
| GSE47630 | KCNB1 | 3745 | 24 | 1 | 15 | |
| GSE54993 | KCNB1 | 3745 | 0 | 17 | 53 | |
| GSE54994 | KCNB1 | 3745 | 27 | 0 | 26 | |
| GSE60625 | KCNB1 | 3745 | 0 | 0 | 11 | |
| GSE74703 | KCNB1 | 3745 | 11 | 0 | 25 | |
| GSE74704 | KCNB1 | 3745 | 12 | 0 | 8 | |
| TCGA | KCNB1 | 3745 | 46 | 3 | 47 |
Total number of gains: 194; Total number of losses: 25; Total Number of normals: 269.
Somatic mutations of KCNB1:
Generating mutation plots.
Highly correlated genes for KCNB1:
Showing top 20/912 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNB1 | SORCS1 | 0.884725 | 4 | 0 | 4 |
| KCNB1 | TGFBR3 | 0.868028 | 4 | 0 | 4 |
| KCNB1 | PI16 | 0.838439 | 4 | 0 | 4 |
| KCNB1 | NACC2 | 0.826086 | 4 | 0 | 4 |
| KCNB1 | ASB5 | 0.815554 | 5 | 0 | 5 |
| KCNB1 | FLNA | 0.809195 | 3 | 0 | 3 |
| KCNB1 | MEIS2 | 0.793555 | 4 | 0 | 4 |
| KCNB1 | DSTN | 0.789195 | 4 | 0 | 4 |
| KCNB1 | HSPB7 | 0.779738 | 5 | 0 | 4 |
| KCNB1 | NTN4 | 0.77972 | 4 | 0 | 4 |
| KCNB1 | TXNIP | 0.777211 | 4 | 0 | 4 |
| KCNB1 | TIMP3 | 0.768751 | 3 | 0 | 3 |
| KCNB1 | LRFN5 | 0.768296 | 5 | 0 | 5 |
| KCNB1 | MEIS1 | 0.765421 | 5 | 0 | 4 |
| KCNB1 | KLF9 | 0.760507 | 4 | 0 | 4 |
| KCNB1 | PTGS1 | 0.756855 | 3 | 0 | 3 |
| KCNB1 | PPP1R9A | 0.756217 | 5 | 0 | 4 |
| KCNB1 | RBFOX3 | 0.754945 | 3 | 0 | 3 |
| KCNB1 | PDE1C | 0.752267 | 8 | 0 | 7 |
| KCNB1 | AFF3 | 0.747345 | 5 | 0 | 4 |
For details and further investigation, click here
