| Full name: integrin linked kinase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 3611 | HGNC ID: HGNC:6040 | Ensembl Gene: ENSG00000166333 | OMIM ID: 602366 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ILK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa04510 | Focal adhesion | |
| hsa05100 | Bacterial invasion of epithelial cells | |
| hsa05213 | Endometrial cancer |
Expression of ILK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ILK | 3611 | 201234_at | -0.6141 | 0.4062 | |
| GSE20347 | ILK | 3611 | 201234_at | -0.4312 | 0.0010 | |
| GSE23400 | ILK | 3611 | 201234_at | -0.3692 | 0.0013 | |
| GSE26886 | ILK | 3611 | 201234_at | -0.3135 | 0.2086 | |
| GSE29001 | ILK | 3611 | 201234_at | -0.2677 | 0.1550 | |
| GSE38129 | ILK | 3611 | 201234_at | -0.6737 | 0.0050 | |
| GSE45670 | ILK | 3611 | 201234_at | -0.6431 | 0.0000 | |
| GSE53622 | ILK | 3611 | 56504 | -0.4023 | 0.0001 | |
| GSE53624 | ILK | 3611 | 56504 | -0.2066 | 0.0078 | |
| GSE63941 | ILK | 3611 | 201234_at | 0.2442 | 0.5034 | |
| GSE77861 | ILK | 3611 | 201234_at | -0.0681 | 0.8394 | |
| GSE97050 | ILK | 3611 | A_23_P105066 | -0.5976 | 0.1752 | |
| SRP007169 | ILK | 3611 | RNAseq | 0.4384 | 0.2570 | |
| SRP008496 | ILK | 3611 | RNAseq | 0.7513 | 0.0057 | |
| SRP064894 | ILK | 3611 | RNAseq | 0.2488 | 0.3976 | |
| SRP133303 | ILK | 3611 | RNAseq | 0.0168 | 0.9571 | |
| SRP159526 | ILK | 3611 | RNAseq | -0.5786 | 0.0701 | |
| SRP193095 | ILK | 3611 | RNAseq | 0.1475 | 0.3729 | |
| SRP219564 | ILK | 3611 | RNAseq | -0.9375 | 0.2452 | |
| TCGA | ILK | 3611 | RNAseq | -0.2335 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ILK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ILK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ILK | 3611 | 1 | 11 | 18 | |
| GSE20123 | ILK | 3611 | 1 | 11 | 18 | |
| GSE43470 | ILK | 3611 | 1 | 8 | 34 | |
| GSE46452 | ILK | 3611 | 7 | 8 | 44 | |
| GSE47630 | ILK | 3611 | 2 | 12 | 26 | |
| GSE54993 | ILK | 3611 | 3 | 1 | 66 | |
| GSE54994 | ILK | 3611 | 2 | 12 | 39 | |
| GSE60625 | ILK | 3611 | 0 | 0 | 11 | |
| GSE74703 | ILK | 3611 | 1 | 6 | 29 | |
| GSE74704 | ILK | 3611 | 0 | 8 | 12 | |
| TCGA | ILK | 3611 | 9 | 38 | 49 |
Total number of gains: 27; Total number of losses: 115; Total Number of normals: 346.
Somatic mutations of ILK:
Generating mutation plots.
Highly correlated genes for ILK:
Showing top 20/1029 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ILK | ZEB1 | 0.81873 | 3 | 0 | 3 |
| ILK | FIBIN | 0.818509 | 3 | 0 | 3 |
| ILK | CYS1 | 0.817815 | 5 | 0 | 5 |
| ILK | CFL2 | 0.814689 | 5 | 0 | 5 |
| ILK | PARVA | 0.811839 | 9 | 0 | 9 |
| ILK | RGMB | 0.802109 | 4 | 0 | 4 |
| ILK | KANK2 | 0.801654 | 8 | 0 | 7 |
| ILK | PRKG2 | 0.78799 | 3 | 0 | 3 |
| ILK | TSPAN2 | 0.780396 | 7 | 0 | 7 |
| ILK | ADARB1 | 0.780279 | 8 | 0 | 7 |
| ILK | DIXDC1 | 0.777901 | 8 | 0 | 7 |
| ILK | SLMAP | 0.777829 | 4 | 0 | 4 |
| ILK | SPOP | 0.769076 | 6 | 0 | 5 |
| ILK | AP1S2 | 0.768642 | 6 | 0 | 6 |
| ILK | LRCH2 | 0.767988 | 5 | 0 | 5 |
| ILK | STARD9 | 0.761063 | 4 | 0 | 4 |
| ILK | DDR2 | 0.761019 | 8 | 0 | 8 |
| ILK | HMCN1 | 0.757828 | 5 | 0 | 5 |
| ILK | LAMA4 | 0.757251 | 7 | 0 | 7 |
| ILK | PRICKLE2 | 0.750902 | 5 | 0 | 4 |
For details and further investigation, click here
