| Full name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | Alias Symbol: GATD4 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 790 | HGNC ID: HGNC:1424 | Ensembl Gene: ENSG00000084774 | OMIM ID: 114010 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CAD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAD | 790 | 202715_at | 1.0019 | 0.0366 | |
| GSE20347 | CAD | 790 | 202715_at | 0.9019 | 0.0000 | |
| GSE23400 | CAD | 790 | 202715_at | 0.8291 | 0.0000 | |
| GSE26886 | CAD | 790 | 202715_at | 1.4707 | 0.0000 | |
| GSE29001 | CAD | 790 | 202715_at | 0.7118 | 0.0118 | |
| GSE38129 | CAD | 790 | 202715_at | 0.9882 | 0.0000 | |
| GSE45670 | CAD | 790 | 202715_at | 0.9817 | 0.0001 | |
| GSE53622 | CAD | 790 | 75843 | 1.3621 | 0.0000 | |
| GSE53624 | CAD | 790 | 75843 | 1.3816 | 0.0000 | |
| GSE63941 | CAD | 790 | 202715_at | 1.1672 | 0.0095 | |
| GSE77861 | CAD | 790 | 202715_at | 0.9546 | 0.0140 | |
| GSE97050 | CAD | 790 | A_23_P40049 | 1.1693 | 0.0705 | |
| SRP007169 | CAD | 790 | RNAseq | 1.7715 | 0.0000 | |
| SRP008496 | CAD | 790 | RNAseq | 1.3296 | 0.0000 | |
| SRP064894 | CAD | 790 | RNAseq | 1.3563 | 0.0000 | |
| SRP133303 | CAD | 790 | RNAseq | 0.8171 | 0.0000 | |
| SRP159526 | CAD | 790 | RNAseq | 1.0887 | 0.0253 | |
| SRP193095 | CAD | 790 | RNAseq | 0.9670 | 0.0000 | |
| SRP219564 | CAD | 790 | RNAseq | 0.8619 | 0.0138 | |
| TCGA | CAD | 790 | RNAseq | 0.3162 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by CAD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAD | 790 | 11 | 2 | 17 | |
| GSE20123 | CAD | 790 | 11 | 2 | 17 | |
| GSE43470 | CAD | 790 | 3 | 1 | 39 | |
| GSE46452 | CAD | 790 | 3 | 4 | 52 | |
| GSE47630 | CAD | 790 | 8 | 0 | 32 | |
| GSE54993 | CAD | 790 | 0 | 6 | 64 | |
| GSE54994 | CAD | 790 | 10 | 0 | 43 | |
| GSE60625 | CAD | 790 | 0 | 3 | 8 | |
| GSE74703 | CAD | 790 | 3 | 0 | 33 | |
| GSE74704 | CAD | 790 | 9 | 1 | 10 | |
| TCGA | CAD | 790 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of CAD:
Generating mutation plots.
Highly correlated genes for CAD:
Showing top 20/2206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAD | UBE2T | 0.818699 | 8 | 0 | 8 |
| CAD | DNMT1 | 0.800692 | 12 | 0 | 12 |
| CAD | DDX39A | 0.799123 | 12 | 0 | 12 |
| CAD | UCK2 | 0.79755 | 3 | 0 | 3 |
| CAD | PSME4 | 0.793084 | 11 | 0 | 11 |
| CAD | CENPA | 0.790608 | 11 | 0 | 10 |
| CAD | CKS1B | 0.790314 | 12 | 0 | 12 |
| CAD | CDCA3 | 0.788536 | 11 | 0 | 10 |
| CAD | FANCI | 0.786971 | 11 | 0 | 11 |
| CAD | UBE2C | 0.783628 | 12 | 0 | 12 |
| CAD | CENPF | 0.781339 | 12 | 0 | 12 |
| CAD | XPO1 | 0.779015 | 11 | 0 | 11 |
| CAD | MCM6 | 0.778113 | 12 | 0 | 11 |
| CAD | RUVBL1 | 0.777558 | 12 | 0 | 12 |
| CAD | RFC4 | 0.777475 | 12 | 0 | 12 |
| CAD | MCM2 | 0.777346 | 11 | 0 | 11 |
| CAD | DKC1 | 0.777175 | 3 | 0 | 3 |
| CAD | AURKB | 0.770367 | 12 | 0 | 11 |
| CAD | KPNA2 | 0.770272 | 8 | 0 | 8 |
| CAD | CEP55 | 0.770221 | 11 | 0 | 10 |
For details and further investigation, click here
