| Full name: xenotropic and polytropic retrovirus receptor 1 | Alias Symbol: SYG1|X3|SLC53A1 | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 9213 | HGNC ID: HGNC:12827 | Ensembl Gene: ENSG00000143324 | OMIM ID: 605237 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of XPR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XPR1 | 9213 | 222581_at | 0.8988 | 0.0821 | |
| GSE26886 | XPR1 | 9213 | 222581_at | 1.4551 | 0.0000 | |
| GSE45670 | XPR1 | 9213 | 222581_at | 1.1267 | 0.0000 | |
| GSE53622 | XPR1 | 9213 | 43787 | 1.4328 | 0.0000 | |
| GSE53624 | XPR1 | 9213 | 43787 | 1.4589 | 0.0000 | |
| GSE63941 | XPR1 | 9213 | 222581_at | 0.5893 | 0.2601 | |
| GSE77861 | XPR1 | 9213 | 222581_at | 1.7646 | 0.0011 | |
| GSE97050 | XPR1 | 9213 | A_24_P336417 | 0.7950 | 0.0867 | |
| SRP007169 | XPR1 | 9213 | RNAseq | 2.1043 | 0.0000 | |
| SRP008496 | XPR1 | 9213 | RNAseq | 2.0011 | 0.0000 | |
| SRP064894 | XPR1 | 9213 | RNAseq | 1.4452 | 0.0000 | |
| SRP133303 | XPR1 | 9213 | RNAseq | 1.2409 | 0.0000 | |
| SRP159526 | XPR1 | 9213 | RNAseq | 1.6847 | 0.0002 | |
| SRP193095 | XPR1 | 9213 | RNAseq | 1.3709 | 0.0000 | |
| SRP219564 | XPR1 | 9213 | RNAseq | 1.7153 | 0.0000 | |
| TCGA | XPR1 | 9213 | RNAseq | 0.4630 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by XPR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XPR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XPR1 | 9213 | 12 | 0 | 18 | |
| GSE20123 | XPR1 | 9213 | 12 | 0 | 18 | |
| GSE43470 | XPR1 | 9213 | 7 | 1 | 35 | |
| GSE46452 | XPR1 | 9213 | 3 | 1 | 55 | |
| GSE47630 | XPR1 | 9213 | 14 | 0 | 26 | |
| GSE54993 | XPR1 | 9213 | 0 | 6 | 64 | |
| GSE54994 | XPR1 | 9213 | 15 | 0 | 38 | |
| GSE60625 | XPR1 | 9213 | 0 | 0 | 11 | |
| GSE74703 | XPR1 | 9213 | 7 | 1 | 28 | |
| GSE74704 | XPR1 | 9213 | 5 | 0 | 15 | |
| TCGA | XPR1 | 9213 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of XPR1:
Generating mutation plots.
Highly correlated genes for XPR1:
Showing top 20/2232 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XPR1 | MYH9 | 0.851945 | 4 | 0 | 4 |
| XPR1 | KHSRP | 0.840119 | 4 | 0 | 4 |
| XPR1 | PYCR2 | 0.837511 | 3 | 0 | 3 |
| XPR1 | PLAU | 0.831068 | 7 | 0 | 7 |
| XPR1 | FMNL2 | 0.823602 | 7 | 0 | 7 |
| XPR1 | CCT5 | 0.816826 | 4 | 0 | 4 |
| XPR1 | LPCAT1 | 0.814452 | 7 | 0 | 7 |
| XPR1 | TMEM184B | 0.810099 | 7 | 0 | 7 |
| XPR1 | LAMC2 | 0.809202 | 7 | 0 | 7 |
| XPR1 | SLC20A1 | 0.80615 | 3 | 0 | 3 |
| XPR1 | ZNF469 | 0.801714 | 6 | 0 | 6 |
| XPR1 | MFAP2 | 0.800105 | 7 | 0 | 7 |
| XPR1 | MMP12 | 0.798313 | 7 | 0 | 7 |
| XPR1 | VOPP1 | 0.797655 | 7 | 0 | 7 |
| XPR1 | DNMT1 | 0.796931 | 7 | 0 | 7 |
| XPR1 | NCAPH | 0.79676 | 4 | 0 | 4 |
| XPR1 | SLC39A3 | 0.793986 | 3 | 0 | 3 |
| XPR1 | HOMER3 | 0.793599 | 6 | 0 | 6 |
| XPR1 | ALPK2 | 0.791254 | 3 | 0 | 3 |
| XPR1 | CDH3 | 0.791249 | 5 | 0 | 5 |
For details and further investigation, click here
