AKT1

 

Full name: AKT serine/threonine kinase 1 Alias Symbol: RAC|PKB|PRKBA|AKT
Type: protein-coding gene Cytoband: 14q32.33
Entrez ID: 207 HGNC ID: HGNC:391 Ensembl Gene: ENSG00000142208 OMIM ID: 164730
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 8/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

AKT1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04530Tight junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04973Carbohydrate digestion and absorption
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of AKT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AKT1 207 207163_s_at 0.7241 0.1411
GSE20347 AKT1 207 207163_s_at 0.3095 0.0605
GSE23400 AKT1 207 207163_s_at 0.4160 0.0000
GSE26886 AKT1 207 207163_s_at -0.0974 0.6508
GSE29001 AKT1 207 207163_s_at 0.4680 0.1662
GSE38129 AKT1 207 207163_s_at 0.2250 0.0732
GSE45670 AKT1 207 207163_s_at 0.3395 0.0077
GSE53622 AKT1 207 90083 0.3778 0.0000
GSE53624 AKT1 207 64871 0.5248 0.0000
GSE63941 AKT1 207 207163_s_at 0.7839 0.0825
GSE77861 AKT1 207 207163_s_at 0.5664 0.1330
GSE97050 AKT1 207 A_33_P3275235 0.1037 0.7271
SRP007169 AKT1 207 RNAseq 0.7985 0.0289
SRP008496 AKT1 207 RNAseq 0.9185 0.0000
SRP064894 AKT1 207 RNAseq 0.4001 0.0039
SRP133303 AKT1 207 RNAseq 0.6366 0.0000
SRP159526 AKT1 207 RNAseq 0.6752 0.0188
SRP193095 AKT1 207 RNAseq 0.6048 0.0000
SRP219564 AKT1 207 RNAseq 0.0823 0.8213
TCGA AKT1 207 RNAseq -0.0934 0.0220

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by AKT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AKT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AKT1 207 11 3 16
GSE20123 AKT1 207 10 2 18
GSE43470 AKT1 207 6 4 33
GSE46452 AKT1 207 19 4 36
GSE47630 AKT1 207 10 8 22
GSE54993 AKT1 207 4 10 56
GSE54994 AKT1 207 20 4 29
GSE60625 AKT1 207 0 2 9
GSE74703 AKT1 207 5 3 28
GSE74704 AKT1 207 5 2 13
TCGA AKT1 207 32 18 46

Total number of gains: 122; Total number of losses: 60; Total Number of normals: 306.  

 

Somatic mutations of AKT1:

 

Generating mutation plots.

 

Highly correlated genes for AKT1:

 

Showing top 20/821 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AKT1UBE2M0.784456303
AKT1SLC39A30.771375303
AKT1SIX50.764007303
AKT1DNAH140.759322404
AKT1INTS30.755225404
AKT1SCAF10.754001303
AKT1TKT0.726325303
AKT1KLC10.723507505
AKT1DYNC1H10.71792811010
AKT1KRTCAP20.71768403
AKT1DPYSL20.714442303
AKT1NKX2-20.709383303
AKT1SIVA10.70648812011
AKT1ACBD60.700592303
AKT1LANCL20.699327303
AKT1TSPAN20.697081303
AKT1PIAS30.694015303
AKT1ZFPL10.693616303
AKT1TMTC40.688203303
AKT1TMEM2050.688183303

For details and further investigation, click here