| Full name: pleckstrin homology and RhoGEF domain containing G2 | Alias Symbol: CLG|FLJ00018|ARHGEF42 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 64857 | HGNC ID: HGNC:29515 | Ensembl Gene: ENSG00000090924 | OMIM ID: 611893 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHG2 | 64857 | 1558407_at | 0.0022 | 0.9954 | |
| GSE26886 | PLEKHG2 | 64857 | 1558407_at | -0.0537 | 0.6106 | |
| GSE45670 | PLEKHG2 | 64857 | 1558407_at | 0.2236 | 0.0110 | |
| GSE53622 | PLEKHG2 | 64857 | 38160 | 1.0525 | 0.0000 | |
| GSE53624 | PLEKHG2 | 64857 | 9673 | 0.9144 | 0.0000 | |
| GSE63941 | PLEKHG2 | 64857 | 1558407_at | -0.1079 | 0.3582 | |
| GSE77861 | PLEKHG2 | 64857 | 1558407_at | -0.0497 | 0.5781 | |
| GSE97050 | PLEKHG2 | 64857 | A_33_P3309175 | 0.5589 | 0.1891 | |
| SRP007169 | PLEKHG2 | 64857 | RNAseq | 1.2064 | 0.0524 | |
| SRP008496 | PLEKHG2 | 64857 | RNAseq | 0.6496 | 0.0842 | |
| SRP064894 | PLEKHG2 | 64857 | RNAseq | 0.8413 | 0.0001 | |
| SRP133303 | PLEKHG2 | 64857 | RNAseq | 0.4791 | 0.0028 | |
| SRP159526 | PLEKHG2 | 64857 | RNAseq | 0.6407 | 0.0612 | |
| SRP193095 | PLEKHG2 | 64857 | RNAseq | 0.8509 | 0.0000 | |
| SRP219564 | PLEKHG2 | 64857 | RNAseq | 0.4481 | 0.2802 | |
| TCGA | PLEKHG2 | 64857 | RNAseq | 0.1439 | 0.0346 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PLEKHG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHG2 | 64857 | 7 | 4 | 19 | |
| GSE20123 | PLEKHG2 | 64857 | 7 | 3 | 20 | |
| GSE43470 | PLEKHG2 | 64857 | 3 | 11 | 29 | |
| GSE46452 | PLEKHG2 | 64857 | 48 | 1 | 10 | |
| GSE47630 | PLEKHG2 | 64857 | 9 | 5 | 26 | |
| GSE54993 | PLEKHG2 | 64857 | 17 | 3 | 50 | |
| GSE54994 | PLEKHG2 | 64857 | 7 | 9 | 37 | |
| GSE60625 | PLEKHG2 | 64857 | 9 | 0 | 2 | |
| GSE74703 | PLEKHG2 | 64857 | 3 | 7 | 26 | |
| GSE74704 | PLEKHG2 | 64857 | 7 | 1 | 12 | |
| TCGA | PLEKHG2 | 64857 | 14 | 16 | 66 |
Total number of gains: 131; Total number of losses: 60; Total Number of normals: 297.
Somatic mutations of PLEKHG2:
Generating mutation plots.
Highly correlated genes for PLEKHG2:
Showing top 20/332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHG2 | GRAMD1A | 0.798702 | 3 | 0 | 3 |
| PLEKHG2 | MYO5A | 0.766437 | 3 | 0 | 3 |
| PLEKHG2 | ACSL4 | 0.752838 | 3 | 0 | 3 |
| PLEKHG2 | RAB34 | 0.747571 | 3 | 0 | 3 |
| PLEKHG2 | GALNT10 | 0.737451 | 3 | 0 | 3 |
| PLEKHG2 | HIBADH | 0.737067 | 3 | 0 | 3 |
| PLEKHG2 | VAC14 | 0.729879 | 3 | 0 | 3 |
| PLEKHG2 | HEYL | 0.72709 | 3 | 0 | 3 |
| PLEKHG2 | THOC5 | 0.724382 | 3 | 0 | 3 |
| PLEKHG2 | TP53I13 | 0.723544 | 3 | 0 | 3 |
| PLEKHG2 | PIGT | 0.720681 | 3 | 0 | 3 |
| PLEKHG2 | YIF1A | 0.718643 | 3 | 0 | 3 |
| PLEKHG2 | DYNC1H1 | 0.717338 | 3 | 0 | 3 |
| PLEKHG2 | FOXK2 | 0.714944 | 3 | 0 | 3 |
| PLEKHG2 | ACLY | 0.706804 | 3 | 0 | 3 |
| PLEKHG2 | SNRPB2 | 0.705839 | 3 | 0 | 3 |
| PLEKHG2 | DNAH11 | 0.703837 | 3 | 0 | 3 |
| PLEKHG2 | TUBG1 | 0.702641 | 3 | 0 | 3 |
| PLEKHG2 | SCNM1 | 0.700775 | 3 | 0 | 3 |
| PLEKHG2 | FADS1 | 0.700218 | 3 | 0 | 3 |
For details and further investigation, click here
