IMP4

 

Full name: IMP U3 small nucleolar ribonucleoprotein 4 Alias Symbol: MGC19606|BXDC4
Type: protein-coding gene Cytoband: 2q21.1
Entrez ID: 92856 HGNC ID: HGNC:30856 Ensembl Gene: ENSG00000136718 OMIM ID: 612981
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of IMP4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IMP4 92856 212411_at 0.7923 0.0152
GSE20347 IMP4 92856 212411_at 0.4480 0.0181
GSE23400 IMP4 92856 212411_at 0.6754 0.0000
GSE26886 IMP4 92856 212411_at 0.9899 0.0000
GSE29001 IMP4 92856 212411_at 0.6940 0.0515
GSE38129 IMP4 92856 212411_at 0.5966 0.0000
GSE45670 IMP4 92856 212411_at 0.5291 0.0073
GSE53622 IMP4 92856 32169 0.6406 0.0000
GSE53624 IMP4 92856 32169 0.8626 0.0000
GSE63941 IMP4 92856 212411_at 1.2918 0.0045
GSE77861 IMP4 92856 212411_at 0.5584 0.0052
GSE97050 IMP4 92856 A_23_P302094 0.4246 0.1920
SRP007169 IMP4 92856 RNAseq 0.7246 0.0653
SRP008496 IMP4 92856 RNAseq 0.7946 0.0010
SRP064894 IMP4 92856 RNAseq 0.4080 0.0400
SRP133303 IMP4 92856 RNAseq 0.4009 0.0005
SRP159526 IMP4 92856 RNAseq 0.4358 0.1560
SRP193095 IMP4 92856 RNAseq 0.3227 0.0069
SRP219564 IMP4 92856 RNAseq 0.1346 0.6302
TCGA IMP4 92856 RNAseq 0.1080 0.0468

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by IMP4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IMP4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IMP4 92856 5 3 22
GSE20123 IMP4 92856 5 3 22
GSE43470 IMP4 92856 2 2 39
GSE46452 IMP4 92856 1 3 55
GSE47630 IMP4 92856 5 0 35
GSE54993 IMP4 92856 0 6 64
GSE54994 IMP4 92856 11 0 42
GSE60625 IMP4 92856 0 3 8
GSE74703 IMP4 92856 2 1 33
GSE74704 IMP4 92856 3 1 16
TCGA IMP4 92856 22 9 65

Total number of gains: 56; Total number of losses: 31; Total Number of normals: 401.  

 

Somatic mutations of IMP4:

 

Generating mutation plots.

 

Highly correlated genes for IMP4:

 

Showing top 20/2109 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IMP4EBNA1BP20.79423303
IMP4PYCR20.793124303
IMP4SIX40.776599707
IMP4CTU20.776458606
IMP4NTMT10.759398606
IMP4SCYL10.753364505
IMP4CDCA20.745569504
IMP4MRPL470.744605808
IMP4DDX39A0.74457712012
IMP4PNO10.743545707
IMP4GNPNAT10.743375303
IMP4PTRH20.74249411010
IMP4NIFK0.741438707
IMP4ANAPC10.740582303
IMP4POLR2D0.7383612011
IMP4RNASEH2A0.73811812012
IMP4TTL0.73757707
IMP4GPR1530.737123404
IMP4XPR10.736749707
IMP4RUVBL10.73669412012

For details and further investigation, click here