SIVA1

 

Full name: SIVA1 apoptosis inducing factor Alias Symbol: SIVA|Siva-1|Siva-2|CD27BP
Type: protein-coding gene Cytoband: 14q32.33
Entrez ID: 10572 HGNC ID: HGNC:17712 Ensembl Gene: ENSG00000184990 OMIM ID: 605567
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of SIVA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SIVA1 10572 210792_x_at 0.8724 0.1134
GSE20347 SIVA1 10572 210792_x_at 0.7956 0.0000
GSE23400 SIVA1 10572 210792_x_at 0.5946 0.0000
GSE26886 SIVA1 10572 210792_x_at 1.0419 0.0000
GSE29001 SIVA1 10572 210792_x_at 0.9589 0.0030
GSE38129 SIVA1 10572 210792_x_at 0.7611 0.0000
GSE45670 SIVA1 10572 210792_x_at 0.2460 0.1732
GSE53622 SIVA1 10572 83933 0.6015 0.0000
GSE53624 SIVA1 10572 83933 0.8844 0.0000
GSE63941 SIVA1 10572 203489_at 1.0526 0.0188
GSE77861 SIVA1 10572 210792_x_at 0.3869 0.2946
GSE97050 SIVA1 10572 A_24_P116351 0.4072 0.3376
SRP007169 SIVA1 10572 RNAseq 0.7933 0.0433
SRP008496 SIVA1 10572 RNAseq 0.6346 0.0177
SRP064894 SIVA1 10572 RNAseq 0.9757 0.0094
SRP133303 SIVA1 10572 RNAseq 0.8027 0.0000
SRP159526 SIVA1 10572 RNAseq 0.9958 0.0116
SRP193095 SIVA1 10572 RNAseq 0.4531 0.0117
SRP219564 SIVA1 10572 RNAseq 0.4322 0.3028
TCGA SIVA1 10572 RNAseq 0.0993 0.0586

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SIVA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SIVA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SIVA1 10572 11 3 16
GSE20123 SIVA1 10572 10 2 18
GSE43470 SIVA1 10572 6 4 33
GSE46452 SIVA1 10572 19 4 36
GSE47630 SIVA1 10572 10 8 22
GSE54993 SIVA1 10572 4 10 56
GSE54994 SIVA1 10572 20 4 29
GSE60625 SIVA1 10572 0 2 9
GSE74703 SIVA1 10572 5 3 28
GSE74704 SIVA1 10572 5 2 13
TCGA SIVA1 10572 32 18 46

Total number of gains: 122; Total number of losses: 60; Total Number of normals: 306.  

 

Somatic mutations of SIVA1:

 

Generating mutation plots.

 

Highly correlated genes for SIVA1:

 

Showing top 20/1798 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SIVA1ROMO10.831804303
SIVA1RFTN20.830451303
SIVA1PSMC10.77851707
SIVA1ANG0.769211303
SIVA1WDR540.768972707
SIVA1ASB20.758421303
SIVA1ISCA20.757409606
SIVA1KTI120.755603303
SIVA1RAB340.755496303
SIVA1TBC1D250.748425303
SIVA1GLRX50.74303813010
SIVA1FLNB0.741727303
SIVA1PMPCB0.737267303
SIVA1GHDC0.734463303
SIVA1PROX10.728702303
SIVA1METTL230.72677706
SIVA1ATXN1L0.726673303
SIVA1NTMT10.724568606
SIVA1MNAT10.72363211010
SIVA1TP53I130.722847606

For details and further investigation, click here