| Full name: solute carrier family 46 member 1 | Alias Symbol: HCP1|MGC9564|PCFT | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 113235 | HGNC ID: HGNC:30521 | Ensembl Gene: ENSG00000076351 | OMIM ID: 611672 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC46A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC46A1 | 113235 | 1552279_a_at | 0.4888 | 0.0373 | |
| GSE26886 | SLC46A1 | 113235 | 1552279_a_at | 0.3364 | 0.0047 | |
| GSE45670 | SLC46A1 | 113235 | 1552279_a_at | 0.3100 | 0.0015 | |
| GSE63941 | SLC46A1 | 113235 | 1558703_at | 0.2718 | 0.7445 | |
| GSE77861 | SLC46A1 | 113235 | 1552279_a_at | 0.1160 | 0.3473 | |
| GSE97050 | SLC46A1 | 113235 | A_33_P3235611 | -0.1711 | 0.5191 | |
| SRP007169 | SLC46A1 | 113235 | RNAseq | 1.4154 | 0.0131 | |
| SRP008496 | SLC46A1 | 113235 | RNAseq | 2.1543 | 0.0000 | |
| SRP064894 | SLC46A1 | 113235 | RNAseq | 0.6821 | 0.0185 | |
| SRP133303 | SLC46A1 | 113235 | RNAseq | -0.1195 | 0.5407 | |
| SRP159526 | SLC46A1 | 113235 | RNAseq | 0.6981 | 0.0348 | |
| SRP193095 | SLC46A1 | 113235 | RNAseq | 0.4407 | 0.0226 | |
| SRP219564 | SLC46A1 | 113235 | RNAseq | 1.2935 | 0.0145 | |
| TCGA | SLC46A1 | 113235 | RNAseq | -0.3025 | 0.0114 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SLC46A1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SLC46A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC46A1 | 113235 | 9 | 1 | 20 | |
| GSE20123 | SLC46A1 | 113235 | 9 | 1 | 20 | |
| GSE43470 | SLC46A1 | 113235 | 0 | 1 | 42 | |
| GSE46452 | SLC46A1 | 113235 | 33 | 1 | 25 | |
| GSE47630 | SLC46A1 | 113235 | 7 | 1 | 32 | |
| GSE54993 | SLC46A1 | 113235 | 2 | 3 | 65 | |
| GSE54994 | SLC46A1 | 113235 | 7 | 6 | 40 | |
| GSE60625 | SLC46A1 | 113235 | 4 | 0 | 7 | |
| GSE74703 | SLC46A1 | 113235 | 0 | 1 | 35 | |
| GSE74704 | SLC46A1 | 113235 | 7 | 1 | 12 | |
| TCGA | SLC46A1 | 113235 | 21 | 10 | 65 |
Total number of gains: 99; Total number of losses: 26; Total Number of normals: 363.
Somatic mutations of SLC46A1:
Generating mutation plots.
Highly correlated genes for SLC46A1:
Showing top 20/341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC46A1 | BCORL1 | 0.782251 | 3 | 0 | 3 |
| SLC46A1 | MYH10 | 0.771509 | 3 | 0 | 3 |
| SLC46A1 | TEAD4 | 0.770232 | 4 | 0 | 4 |
| SLC46A1 | CCT5 | 0.746015 | 3 | 0 | 3 |
| SLC46A1 | CHST12 | 0.742525 | 3 | 0 | 3 |
| SLC46A1 | RPTOR | 0.741972 | 3 | 0 | 3 |
| SLC46A1 | SCARB1 | 0.736474 | 3 | 0 | 3 |
| SLC46A1 | ZNF579 | 0.734611 | 3 | 0 | 3 |
| SLC46A1 | DGKD | 0.731079 | 3 | 0 | 3 |
| SLC46A1 | NFKB2 | 0.72523 | 3 | 0 | 3 |
| SLC46A1 | SIX5 | 0.721769 | 3 | 0 | 3 |
| SLC46A1 | CIC | 0.711451 | 3 | 0 | 3 |
| SLC46A1 | DYNC1H1 | 0.711037 | 4 | 0 | 4 |
| SLC46A1 | VEGFB | 0.709792 | 3 | 0 | 3 |
| SLC46A1 | ABL2 | 0.709256 | 4 | 0 | 4 |
| SLC46A1 | KDM6B | 0.709221 | 3 | 0 | 3 |
| SLC46A1 | VANGL2 | 0.709025 | 3 | 0 | 3 |
| SLC46A1 | CHD8 | 0.708823 | 3 | 0 | 3 |
| SLC46A1 | PITX2 | 0.704225 | 3 | 0 | 3 |
| SLC46A1 | NRSN2 | 0.702427 | 3 | 0 | 3 |
For details and further investigation, click here
