| Full name: enoyl-CoA hydratase 1 | Alias Symbol: HPXEL | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 1891 | HGNC ID: HGNC:3149 | Ensembl Gene: ENSG00000104823 | OMIM ID: 600696 |
| Drug and gene relationship at DGIdb | |||
Expression of ECH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ECH1 | 1891 | 200789_at | -0.1646 | 0.4710 | |
| GSE20347 | ECH1 | 1891 | 200789_at | -0.4055 | 0.0139 | |
| GSE23400 | ECH1 | 1891 | 200789_at | -0.2530 | 0.0002 | |
| GSE26886 | ECH1 | 1891 | 200789_at | -0.4910 | 0.0148 | |
| GSE29001 | ECH1 | 1891 | 200789_at | -0.2858 | 0.2532 | |
| GSE38129 | ECH1 | 1891 | 200789_at | -0.3557 | 0.0034 | |
| GSE45670 | ECH1 | 1891 | 200789_at | -0.2561 | 0.0261 | |
| GSE63941 | ECH1 | 1891 | 200789_at | 1.3831 | 0.0862 | |
| GSE77861 | ECH1 | 1891 | 200789_at | 0.0309 | 0.9243 | |
| GSE97050 | ECH1 | 1891 | A_23_P153853 | -0.2018 | 0.4692 | |
| SRP007169 | ECH1 | 1891 | RNAseq | 0.0929 | 0.8557 | |
| SRP008496 | ECH1 | 1891 | RNAseq | -0.3172 | 0.3470 | |
| SRP064894 | ECH1 | 1891 | RNAseq | 0.1197 | 0.6902 | |
| SRP133303 | ECH1 | 1891 | RNAseq | -0.2628 | 0.1840 | |
| SRP159526 | ECH1 | 1891 | RNAseq | -0.1278 | 0.5063 | |
| SRP193095 | ECH1 | 1891 | RNAseq | -0.5934 | 0.0000 | |
| SRP219564 | ECH1 | 1891 | RNAseq | -0.7003 | 0.0306 | |
| TCGA | ECH1 | 1891 | RNAseq | -0.1283 | 0.0201 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ECH1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ECH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ECH1 | 1891 | 7 | 4 | 19 | |
| GSE20123 | ECH1 | 1891 | 7 | 3 | 20 | |
| GSE43470 | ECH1 | 1891 | 4 | 10 | 29 | |
| GSE46452 | ECH1 | 1891 | 47 | 2 | 10 | |
| GSE47630 | ECH1 | 1891 | 9 | 5 | 26 | |
| GSE54993 | ECH1 | 1891 | 17 | 3 | 50 | |
| GSE54994 | ECH1 | 1891 | 6 | 9 | 38 | |
| GSE60625 | ECH1 | 1891 | 9 | 0 | 2 | |
| GSE74703 | ECH1 | 1891 | 4 | 6 | 26 | |
| GSE74704 | ECH1 | 1891 | 7 | 1 | 12 | |
| TCGA | ECH1 | 1891 | 15 | 15 | 66 |
Total number of gains: 132; Total number of losses: 58; Total Number of normals: 298.
Somatic mutations of ECH1:
Generating mutation plots.
Highly correlated genes for ECH1:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ECH1 | ZNF383 | 0.762802 | 3 | 0 | 3 |
| ECH1 | ZFP30 | 0.759978 | 3 | 0 | 3 |
| ECH1 | KDM3B | 0.747933 | 3 | 0 | 3 |
| ECH1 | SETMAR | 0.742434 | 3 | 0 | 3 |
| ECH1 | KLHDC8B | 0.740305 | 3 | 0 | 3 |
| ECH1 | ABHD16A | 0.729186 | 3 | 0 | 3 |
| ECH1 | ANKRD13A | 0.728908 | 3 | 0 | 3 |
| ECH1 | TOPORS | 0.727446 | 3 | 0 | 3 |
| ECH1 | ALKBH7 | 0.723732 | 3 | 0 | 3 |
| ECH1 | KLHDC9 | 0.723633 | 3 | 0 | 3 |
| ECH1 | CNST | 0.716044 | 4 | 0 | 4 |
| ECH1 | DNAJB6 | 0.714611 | 3 | 0 | 3 |
| ECH1 | SNAPIN | 0.714421 | 3 | 0 | 3 |
| ECH1 | C20orf194 | 0.707955 | 3 | 0 | 3 |
| ECH1 | HMGCS1 | 0.707453 | 3 | 0 | 3 |
| ECH1 | SORL1 | 0.70446 | 3 | 0 | 3 |
| ECH1 | ZNF615 | 0.701466 | 3 | 0 | 3 |
| ECH1 | FAM98C | 0.695522 | 6 | 0 | 6 |
| ECH1 | ULK3 | 0.688673 | 3 | 0 | 3 |
| ECH1 | TMEM120A | 0.688644 | 3 | 0 | 3 |
For details and further investigation, click here
