| Full name: TOP1 binding arginine/serine rich protein | Alias Symbol: TP53BPL|LUN | ||
| Type: protein-coding gene | Cytoband: 9p21.1 | ||
| Entrez ID: 10210 | HGNC ID: HGNC:21653 | Ensembl Gene: ENSG00000197579 | OMIM ID: 609507 |
| Drug and gene relationship at DGIdb | |||
Expression of TOPORS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOPORS | 10210 | 204071_s_at | -0.1363 | 0.8072 | |
| GSE20347 | TOPORS | 10210 | 204071_s_at | -0.4614 | 0.0325 | |
| GSE23400 | TOPORS | 10210 | 204071_s_at | 0.0710 | 0.2816 | |
| GSE26886 | TOPORS | 10210 | 204071_s_at | -1.6604 | 0.0000 | |
| GSE29001 | TOPORS | 10210 | 204071_s_at | -0.0616 | 0.8758 | |
| GSE38129 | TOPORS | 10210 | 204071_s_at | -0.3291 | 0.0285 | |
| GSE45670 | TOPORS | 10210 | 204071_s_at | -0.0607 | 0.7370 | |
| GSE53622 | TOPORS | 10210 | 76941 | -0.3453 | 0.0000 | |
| GSE53624 | TOPORS | 10210 | 76941 | -0.2313 | 0.0033 | |
| GSE63941 | TOPORS | 10210 | 204071_s_at | -0.3858 | 0.4520 | |
| GSE77861 | TOPORS | 10210 | 204071_s_at | 0.2249 | 0.8103 | |
| GSE97050 | TOPORS | 10210 | A_23_P32217 | -0.5821 | 0.1499 | |
| SRP007169 | TOPORS | 10210 | RNAseq | -0.7239 | 0.0425 | |
| SRP008496 | TOPORS | 10210 | RNAseq | -0.3934 | 0.0510 | |
| SRP064894 | TOPORS | 10210 | RNAseq | -0.3668 | 0.0838 | |
| SRP133303 | TOPORS | 10210 | RNAseq | -0.2968 | 0.0060 | |
| SRP159526 | TOPORS | 10210 | RNAseq | -0.5746 | 0.0014 | |
| SRP193095 | TOPORS | 10210 | RNAseq | -0.5719 | 0.0000 | |
| SRP219564 | TOPORS | 10210 | RNAseq | -0.5681 | 0.0931 | |
| TCGA | TOPORS | 10210 | RNAseq | -0.1121 | 0.0548 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TOPORS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOPORS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOPORS | 10210 | 2 | 15 | 13 | |
| GSE20123 | TOPORS | 10210 | 2 | 15 | 13 | |
| GSE43470 | TOPORS | 10210 | 4 | 9 | 30 | |
| GSE46452 | TOPORS | 10210 | 6 | 17 | 36 | |
| GSE47630 | TOPORS | 10210 | 1 | 21 | 18 | |
| GSE54993 | TOPORS | 10210 | 6 | 0 | 64 | |
| GSE54994 | TOPORS | 10210 | 7 | 11 | 35 | |
| GSE60625 | TOPORS | 10210 | 0 | 0 | 11 | |
| GSE74703 | TOPORS | 10210 | 3 | 7 | 26 | |
| GSE74704 | TOPORS | 10210 | 0 | 11 | 9 | |
| TCGA | TOPORS | 10210 | 16 | 45 | 35 |
Total number of gains: 47; Total number of losses: 151; Total Number of normals: 290.
Somatic mutations of TOPORS:
Generating mutation plots.
Highly correlated genes for TOPORS:
Showing top 20/399 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOPORS | GTF2H5 | 0.860648 | 3 | 0 | 3 |
| TOPORS | C5orf51 | 0.822046 | 3 | 0 | 3 |
| TOPORS | NBPF1 | 0.797234 | 3 | 0 | 3 |
| TOPORS | RBM20 | 0.787044 | 3 | 0 | 3 |
| TOPORS | TMCO4 | 0.783764 | 3 | 0 | 3 |
| TOPORS | HNRNPA1 | 0.778808 | 3 | 0 | 3 |
| TOPORS | PRKAG1 | 0.776191 | 3 | 0 | 3 |
| TOPORS | DNAJB6 | 0.768138 | 3 | 0 | 3 |
| TOPORS | ZRANB2 | 0.765723 | 3 | 0 | 3 |
| TOPORS | ZNF324 | 0.764986 | 3 | 0 | 3 |
| TOPORS | GALNT11 | 0.764672 | 3 | 0 | 3 |
| TOPORS | WDFY1 | 0.757306 | 3 | 0 | 3 |
| TOPORS | ZNF136 | 0.755166 | 3 | 0 | 3 |
| TOPORS | FAM160B1 | 0.741399 | 3 | 0 | 3 |
| TOPORS | ZNF564 | 0.730649 | 3 | 0 | 3 |
| TOPORS | ECH1 | 0.727446 | 3 | 0 | 3 |
| TOPORS | MTIF3 | 0.724673 | 3 | 0 | 3 |
| TOPORS | MTX2 | 0.72322 | 3 | 0 | 3 |
| TOPORS | ZKSCAN1 | 0.722284 | 3 | 0 | 3 |
| TOPORS | AKAP17A | 0.720996 | 4 | 0 | 3 |
For details and further investigation, click here
