| Full name: DnaJ heat shock protein family (Hsp40) member B6 | Alias Symbol: MRJ | ||
| Type: protein-coding gene | Cytoband: 7q36.3 | ||
| Entrez ID: 10049 | HGNC ID: HGNC:14888 | Ensembl Gene: ENSG00000105993 | OMIM ID: 611332 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DNAJB6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNAJB6 | 10049 | 209015_s_at | -0.7310 | 0.3251 | |
| GSE20347 | DNAJB6 | 10049 | 209015_s_at | -0.7598 | 0.0004 | |
| GSE23400 | DNAJB6 | 10049 | 209015_s_at | -0.1880 | 0.1150 | |
| GSE26886 | DNAJB6 | 10049 | 209015_s_at | -2.2561 | 0.0000 | |
| GSE29001 | DNAJB6 | 10049 | 209015_s_at | -0.6749 | 0.1669 | |
| GSE38129 | DNAJB6 | 10049 | 209015_s_at | -0.5067 | 0.0075 | |
| GSE45670 | DNAJB6 | 10049 | 209015_s_at | 0.2211 | 0.3197 | |
| GSE53622 | DNAJB6 | 10049 | 4568 | -0.2678 | 0.0071 | |
| GSE53624 | DNAJB6 | 10049 | 102912 | 0.1665 | 0.0099 | |
| GSE63941 | DNAJB6 | 10049 | 209015_s_at | -0.8621 | 0.1689 | |
| GSE77861 | DNAJB6 | 10049 | 209015_s_at | -0.0714 | 0.8688 | |
| GSE97050 | DNAJB6 | 10049 | A_32_P229746 | 0.1739 | 0.4639 | |
| SRP007169 | DNAJB6 | 10049 | RNAseq | 0.1260 | 0.7684 | |
| SRP008496 | DNAJB6 | 10049 | RNAseq | -0.1541 | 0.5495 | |
| SRP064894 | DNAJB6 | 10049 | RNAseq | -0.0220 | 0.8904 | |
| SRP133303 | DNAJB6 | 10049 | RNAseq | 0.1208 | 0.2892 | |
| SRP159526 | DNAJB6 | 10049 | RNAseq | -0.3956 | 0.2707 | |
| SRP193095 | DNAJB6 | 10049 | RNAseq | -0.0567 | 0.7494 | |
| SRP219564 | DNAJB6 | 10049 | RNAseq | -0.6626 | 0.0055 | |
| TCGA | DNAJB6 | 10049 | RNAseq | 0.1313 | 0.0433 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DNAJB6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNAJB6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNAJB6 | 10049 | 4 | 3 | 23 | |
| GSE20123 | DNAJB6 | 10049 | 3 | 3 | 24 | |
| GSE43470 | DNAJB6 | 10049 | 2 | 5 | 36 | |
| GSE46452 | DNAJB6 | 10049 | 7 | 2 | 50 | |
| GSE47630 | DNAJB6 | 10049 | 6 | 9 | 25 | |
| GSE54993 | DNAJB6 | 10049 | 3 | 3 | 64 | |
| GSE54994 | DNAJB6 | 10049 | 6 | 8 | 39 | |
| GSE60625 | DNAJB6 | 10049 | 0 | 0 | 11 | |
| GSE74703 | DNAJB6 | 10049 | 2 | 4 | 30 | |
| GSE74704 | DNAJB6 | 10049 | 1 | 3 | 16 | |
| TCGA | DNAJB6 | 10049 | 28 | 25 | 43 |
Total number of gains: 62; Total number of losses: 65; Total Number of normals: 361.
Somatic mutations of DNAJB6:
Generating mutation plots.
Highly correlated genes for DNAJB6:
Showing top 20/662 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNAJB6 | IER3IP1 | 0.771612 | 3 | 0 | 3 |
| DNAJB6 | EXOC2 | 0.770998 | 3 | 0 | 3 |
| DNAJB6 | PPP2R1B | 0.769799 | 3 | 0 | 3 |
| DNAJB6 | TOPORS | 0.768138 | 3 | 0 | 3 |
| DNAJB6 | SOCS5 | 0.761544 | 3 | 0 | 3 |
| DNAJB6 | TET2 | 0.75036 | 3 | 0 | 3 |
| DNAJB6 | PAPSS1 | 0.743223 | 3 | 0 | 3 |
| DNAJB6 | ZFP3 | 0.740797 | 3 | 0 | 3 |
| DNAJB6 | NAT1 | 0.739645 | 3 | 0 | 3 |
| DNAJB6 | OSBPL8 | 0.738767 | 3 | 0 | 3 |
| DNAJB6 | PRPF38A | 0.730949 | 3 | 0 | 3 |
| DNAJB6 | CAPNS2 | 0.72687 | 4 | 0 | 4 |
| DNAJB6 | EGLN1 | 0.719774 | 4 | 0 | 3 |
| DNAJB6 | RAB8A | 0.716888 | 3 | 0 | 3 |
| DNAJB6 | CSK | 0.715757 | 3 | 0 | 3 |
| DNAJB6 | ECH1 | 0.714611 | 3 | 0 | 3 |
| DNAJB6 | RAC1 | 0.713915 | 4 | 0 | 3 |
| DNAJB6 | SLC35B3 | 0.708671 | 4 | 0 | 3 |
| DNAJB6 | TMEM218 | 0.708279 | 3 | 0 | 3 |
| DNAJB6 | MRPS33 | 0.706209 | 3 | 0 | 3 |
For details and further investigation, click here
