| Full name: unc-51 like kinase 3 | Alias Symbol: DKFZP434C131|FLJ90566 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 25989 | HGNC ID: HGNC:19703 | Ensembl Gene: ENSG00000140474 | OMIM ID: 613472 |
| Drug and gene relationship at DGIdb | |||
ULK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04211 | Longevity regulating pathway - mammal |
Expression of ULK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ULK3 | 25989 | 225067_at | -0.6540 | 0.2113 | |
| GSE26886 | ULK3 | 25989 | 225067_at | -1.6686 | 0.0000 | |
| GSE45670 | ULK3 | 25989 | 225067_at | -0.4793 | 0.0546 | |
| GSE53622 | ULK3 | 25989 | 96332 | -1.2776 | 0.0000 | |
| GSE53624 | ULK3 | 25989 | 96332 | -1.5197 | 0.0000 | |
| GSE63941 | ULK3 | 25989 | 225067_at | 0.5019 | 0.3164 | |
| GSE77861 | ULK3 | 25989 | 225067_at | -1.0943 | 0.0007 | |
| GSE97050 | ULK3 | 25989 | A_23_P206107 | -0.3397 | 0.4324 | |
| SRP007169 | ULK3 | 25989 | RNAseq | -3.2699 | 0.0000 | |
| SRP008496 | ULK3 | 25989 | RNAseq | -2.7160 | 0.0000 | |
| SRP064894 | ULK3 | 25989 | RNAseq | -1.4006 | 0.0000 | |
| SRP133303 | ULK3 | 25989 | RNAseq | -1.7196 | 0.0000 | |
| SRP159526 | ULK3 | 25989 | RNAseq | -1.3494 | 0.0000 | |
| SRP193095 | ULK3 | 25989 | RNAseq | -1.4756 | 0.0000 | |
| SRP219564 | ULK3 | 25989 | RNAseq | -0.5921 | 0.3901 | |
| TCGA | ULK3 | 25989 | RNAseq | -0.0670 | 0.3468 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by ULK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ULK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ULK3 | 25989 | 8 | 1 | 21 | |
| GSE20123 | ULK3 | 25989 | 8 | 1 | 21 | |
| GSE43470 | ULK3 | 25989 | 4 | 6 | 33 | |
| GSE46452 | ULK3 | 25989 | 3 | 7 | 49 | |
| GSE47630 | ULK3 | 25989 | 8 | 10 | 22 | |
| GSE54993 | ULK3 | 25989 | 5 | 6 | 59 | |
| GSE54994 | ULK3 | 25989 | 5 | 7 | 41 | |
| GSE60625 | ULK3 | 25989 | 4 | 0 | 7 | |
| GSE74703 | ULK3 | 25989 | 4 | 3 | 29 | |
| GSE74704 | ULK3 | 25989 | 4 | 1 | 15 | |
| TCGA | ULK3 | 25989 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of ULK3:
Generating mutation plots.
Highly correlated genes for ULK3:
Showing top 20/1649 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ULK3 | PADI1 | 0.881536 | 4 | 0 | 4 |
| ULK3 | SLC16A6 | 0.869931 | 7 | 0 | 7 |
| ULK3 | EHD3 | 0.86915 | 7 | 0 | 7 |
| ULK3 | CYSRT1 | 0.848603 | 6 | 0 | 6 |
| ULK3 | GYS2 | 0.846808 | 6 | 0 | 6 |
| ULK3 | A2ML1 | 0.842909 | 6 | 0 | 6 |
| ULK3 | ANXA9 | 0.841518 | 7 | 0 | 7 |
| ULK3 | ACPP | 0.840734 | 6 | 0 | 6 |
| ULK3 | IL36A | 0.838876 | 6 | 0 | 6 |
| ULK3 | RAB25 | 0.837417 | 7 | 0 | 7 |
| ULK3 | SLC46A2 | 0.833747 | 7 | 0 | 7 |
| ULK3 | USP6NL | 0.832834 | 7 | 0 | 7 |
| ULK3 | ESPL1 | 0.830861 | 6 | 0 | 6 |
| ULK3 | SASH1 | 0.830469 | 7 | 0 | 7 |
| ULK3 | TGM3 | 0.828709 | 6 | 0 | 6 |
| ULK3 | CHP1 | 0.828132 | 6 | 0 | 6 |
| ULK3 | TTC22 | 0.827919 | 6 | 0 | 6 |
| ULK3 | TTC9 | 0.827685 | 7 | 0 | 7 |
| ULK3 | VSIG10L | 0.827505 | 6 | 0 | 6 |
| ULK3 | SCEL | 0.826618 | 6 | 0 | 6 |
For details and further investigation, click here
