| Full name: sortilin related receptor 1 | Alias Symbol: gp250|LR11|LRP9|SorLA|SorLA-1 | ||
| Type: protein-coding gene | Cytoband: 11q24.1 | ||
| Entrez ID: 6653 | HGNC ID: HGNC:11185 | Ensembl Gene: ENSG00000137642 | OMIM ID: 602005 |
| Drug and gene relationship at DGIdb | |||
Expression of SORL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SORL1 | 6653 | 203509_at | -0.0861 | 0.9363 | |
| GSE20347 | SORL1 | 6653 | 203509_at | 0.0456 | 0.8830 | |
| GSE23400 | SORL1 | 6653 | 203509_at | 0.2336 | 0.0386 | |
| GSE26886 | SORL1 | 6653 | 212560_at | 0.8921 | 0.0390 | |
| GSE29001 | SORL1 | 6653 | 203509_at | -0.2104 | 0.5489 | |
| GSE38129 | SORL1 | 6653 | 203509_at | 0.0481 | 0.8262 | |
| GSE45670 | SORL1 | 6653 | 212560_at | -0.1955 | 0.5490 | |
| GSE53622 | SORL1 | 6653 | 17784 | 0.0224 | 0.8567 | |
| GSE53624 | SORL1 | 6653 | 17784 | 0.1228 | 0.2292 | |
| GSE63941 | SORL1 | 6653 | 203509_at | 2.5917 | 0.0009 | |
| GSE77861 | SORL1 | 6653 | 203509_at | 0.7037 | 0.1012 | |
| GSE97050 | SORL1 | 6653 | A_23_P87049 | -0.2756 | 0.2411 | |
| SRP007169 | SORL1 | 6653 | RNAseq | 1.0172 | 0.0655 | |
| SRP008496 | SORL1 | 6653 | RNAseq | 1.3091 | 0.0000 | |
| SRP064894 | SORL1 | 6653 | RNAseq | 0.0537 | 0.8703 | |
| SRP133303 | SORL1 | 6653 | RNAseq | 0.2936 | 0.3840 | |
| SRP159526 | SORL1 | 6653 | RNAseq | 0.2308 | 0.6707 | |
| SRP193095 | SORL1 | 6653 | RNAseq | -0.0402 | 0.8133 | |
| SRP219564 | SORL1 | 6653 | RNAseq | -0.1812 | 0.6593 | |
| TCGA | SORL1 | 6653 | RNAseq | 0.0670 | 0.5401 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SORL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SORL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SORL1 | 6653 | 0 | 13 | 17 | |
| GSE20123 | SORL1 | 6653 | 0 | 13 | 17 | |
| GSE43470 | SORL1 | 6653 | 2 | 7 | 34 | |
| GSE46452 | SORL1 | 6653 | 3 | 26 | 30 | |
| GSE47630 | SORL1 | 6653 | 2 | 19 | 19 | |
| GSE54993 | SORL1 | 6653 | 10 | 0 | 60 | |
| GSE54994 | SORL1 | 6653 | 5 | 19 | 29 | |
| GSE60625 | SORL1 | 6653 | 0 | 3 | 8 | |
| GSE74703 | SORL1 | 6653 | 1 | 5 | 30 | |
| GSE74704 | SORL1 | 6653 | 0 | 9 | 11 | |
| TCGA | SORL1 | 6653 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 164; Total Number of normals: 296.
Somatic mutations of SORL1:
Generating mutation plots.
Highly correlated genes for SORL1:
Showing top 20/357 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SORL1 | CMTM4 | 0.852293 | 3 | 0 | 3 |
| SORL1 | BSG | 0.814476 | 3 | 0 | 3 |
| SORL1 | MRPS30 | 0.808396 | 3 | 0 | 3 |
| SORL1 | ZNF747 | 0.804236 | 3 | 0 | 3 |
| SORL1 | WDR35 | 0.778481 | 3 | 0 | 3 |
| SORL1 | PHIP | 0.776028 | 3 | 0 | 3 |
| SORL1 | MCM3 | 0.77237 | 3 | 0 | 3 |
| SORL1 | ZDHHC2 | 0.768375 | 3 | 0 | 3 |
| SORL1 | AFTPH | 0.763751 | 3 | 0 | 3 |
| SORL1 | TOMM20 | 0.763593 | 3 | 0 | 3 |
| SORL1 | CCT5 | 0.748902 | 3 | 0 | 3 |
| SORL1 | PAN2 | 0.748385 | 4 | 0 | 3 |
| SORL1 | UBL7 | 0.747437 | 3 | 0 | 3 |
| SORL1 | SLC39A10 | 0.744475 | 3 | 0 | 3 |
| SORL1 | PSMD8 | 0.744455 | 3 | 0 | 3 |
| SORL1 | RNPS1 | 0.742523 | 3 | 0 | 3 |
| SORL1 | ERI3 | 0.741038 | 3 | 0 | 3 |
| SORL1 | FZD6 | 0.740111 | 3 | 0 | 3 |
| SORL1 | BANF1 | 0.738339 | 3 | 0 | 3 |
| SORL1 | TMEM106B | 0.737347 | 3 | 0 | 3 |
For details and further investigation, click here
