| Full name: kelch domain containing 8B | Alias Symbol: MGC35097 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 200942 | HGNC ID: HGNC:28557 | Ensembl Gene: ENSG00000185909 | OMIM ID: 613169 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHDC8B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHDC8B | 200942 | 225755_at | -0.6115 | 0.1657 | |
| GSE26886 | KLHDC8B | 200942 | 225755_at | -1.6855 | 0.0000 | |
| GSE45670 | KLHDC8B | 200942 | 225755_at | -0.2425 | 0.3038 | |
| GSE53622 | KLHDC8B | 200942 | 20919 | -1.2561 | 0.0000 | |
| GSE53624 | KLHDC8B | 200942 | 20919 | -1.2507 | 0.0000 | |
| GSE63941 | KLHDC8B | 200942 | 225755_at | -0.8802 | 0.3979 | |
| GSE77861 | KLHDC8B | 200942 | 225755_at | -0.7765 | 0.0032 | |
| GSE97050 | KLHDC8B | 200942 | A_24_P148836 | -0.7437 | 0.2788 | |
| SRP007169 | KLHDC8B | 200942 | RNAseq | -1.6140 | 0.0004 | |
| SRP008496 | KLHDC8B | 200942 | RNAseq | -1.6753 | 0.0000 | |
| SRP064894 | KLHDC8B | 200942 | RNAseq | -0.2620 | 0.3845 | |
| SRP133303 | KLHDC8B | 200942 | RNAseq | -1.1854 | 0.0000 | |
| SRP159526 | KLHDC8B | 200942 | RNAseq | -1.3397 | 0.0004 | |
| SRP193095 | KLHDC8B | 200942 | RNAseq | -0.9380 | 0.0000 | |
| SRP219564 | KLHDC8B | 200942 | RNAseq | -1.2420 | 0.0119 | |
| TCGA | KLHDC8B | 200942 | RNAseq | -0.0991 | 0.3364 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by KLHDC8B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHDC8B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHDC8B | 200942 | 0 | 18 | 12 | |
| GSE20123 | KLHDC8B | 200942 | 0 | 19 | 11 | |
| GSE43470 | KLHDC8B | 200942 | 0 | 18 | 25 | |
| GSE46452 | KLHDC8B | 200942 | 2 | 16 | 41 | |
| GSE47630 | KLHDC8B | 200942 | 1 | 24 | 15 | |
| GSE54993 | KLHDC8B | 200942 | 6 | 2 | 62 | |
| GSE54994 | KLHDC8B | 200942 | 0 | 36 | 17 | |
| GSE60625 | KLHDC8B | 200942 | 5 | 0 | 6 | |
| GSE74703 | KLHDC8B | 200942 | 0 | 14 | 22 | |
| GSE74704 | KLHDC8B | 200942 | 0 | 12 | 8 | |
| TCGA | KLHDC8B | 200942 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of KLHDC8B:
Generating mutation plots.
Highly correlated genes for KLHDC8B:
Showing top 20/1313 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHDC8B | PPP3CB | 0.766971 | 3 | 0 | 3 |
| KLHDC8B | CLEC3B | 0.758054 | 3 | 0 | 3 |
| KLHDC8B | STARD9 | 0.757558 | 3 | 0 | 3 |
| KLHDC8B | RETSAT | 0.75242 | 3 | 0 | 3 |
| KLHDC8B | ACOX2 | 0.752225 | 5 | 0 | 5 |
| KLHDC8B | EPB41 | 0.743457 | 3 | 0 | 3 |
| KLHDC8B | ESYT2 | 0.743047 | 4 | 0 | 3 |
| KLHDC8B | ECH1 | 0.740305 | 3 | 0 | 3 |
| KLHDC8B | KIAA0408 | 0.739828 | 3 | 0 | 3 |
| KLHDC8B | ACOX3 | 0.738899 | 6 | 0 | 6 |
| KLHDC8B | CASQ2 | 0.7373 | 4 | 0 | 4 |
| KLHDC8B | KLHL30 | 0.736168 | 3 | 0 | 3 |
| KLHDC8B | PCP4 | 0.734764 | 4 | 0 | 4 |
| KLHDC8B | FKBP5 | 0.732922 | 3 | 0 | 3 |
| KLHDC8B | CYP21A2 | 0.731743 | 3 | 0 | 3 |
| KLHDC8B | CD59 | 0.729283 | 4 | 0 | 4 |
| KLHDC8B | MIER1 | 0.728745 | 3 | 0 | 3 |
| KLHDC8B | RHBDF1 | 0.728287 | 3 | 0 | 3 |
| KLHDC8B | HOXA3 | 0.724794 | 3 | 0 | 3 |
| KLHDC8B | APIP | 0.724263 | 3 | 0 | 3 |
For details and further investigation, click here
